The use of probiotics to enhance immunity of broiler chicken against some  intestinal infection pathogens

Mohammed, Faten F.; Thabet, Manal H.; Ali, Marwa F.

doi:10.21608/svu.2019.23141

Cited by 7 publications

(7 citation statements)

References 26 publications

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“…The results of current study are also in agreement with other researchers like Zhai et al (2011) and Zhang et al (2015) who reported vitamin E and C as important antioxidants that protect the body from various microbes including bacteria, viruses and parasites. Min et al (2018) and Mohamed et al (2019) also supported an immunomodulatory effect of vitamin E on T cells that may have complimentary effects on the immune function and health of broiler chickens. Habibian et al (2014) reported enhancement of primary and secondary antibody responses while using vitamin E as a feed supplement that also strengthens the findings of our trial.…”

Section: Discussionmentioning

confidence: 80%

Effects of Immune Modulators on the Immune Status of Broiler Chickens

Sheikh¹,

Bajwa²,

Rashid³

et al. 2020

PJZ

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The aim of this study was to examine the influence of immune modulators on the immune competence of broiler chickens. In three experiments (n=240 chicks in each), the immune modulators vitamin C (500 mg/l), vitamin E (200 mg/l), dietary nucleotides (100 mg/l) and DNA (100 mg/l) extracted from chicken liver were separately offered on days 1-21, 1-42 and 22-42 in experiments 1, 2 and 3, respectively. Under standard broiler management conditions, birds were divided into five treatment groups of 48 with four replicates. Commercial pre-starter feed, starter feed and finisher feed were offered on days 1-12, 13-25 and 26-42, respectively. Birds were vaccinated against Newcastle disease virus and infectious bursal disease. Relative lymphoid organ weights were recorded on day 42. Hemagglutination inhibition (HI) assay was performed against Newcastle disease virus on a weekly basis, whilst a hemagglutination (HA) assay was performed to determine immunity against total sheep red blood cell (SRBC) , mercaptoethanol-2 resistant (IgG) and mercaptoethanol-2 sensitive (IgM) antibodies on weeks 3, 4, 5 and 6. Lymphoid organ weight showed non-significant difference (P>0.05), with numerically higher weight in immune modulator groups.The vitamin E supplemented group had highest HI antibody titers (7.22±0.25, 7.36±0.18 and 6.55±0.38).In experiments 1 and 2, supplementation with immune modulators had significant (P<0.05) effects on total SRBC, IgG and IgM titers. In conclusion, vitamin E showed better immuno-modulatory effect followed by vitamin C, nucleotides and DNA, respectively. Supplementation of immuno-modulators at early age (1 to 21 days) showed more promising effect on immune performance of broiler chickens.

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Section: Discussionmentioning

confidence: 80%

Effects of Immune Modulators on the Immune Status of Broiler Chickens

Sheikh¹,

Bajwa²,

Rashid³

et al. 2020

PJZ

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“…Consistent with several previous reports ( 42 , 43 ), supplementation of probiotics ( L. plantarum ) and prebiotics (amylase enzyme) in diet improved the body performance parameters (BW, BWG, and FI) and decreased the FCR. Weight gain in the probiotic-treated group (G2 and G5) might result from preserving healthy intestinal flora by competitive exclusion and antagonism, increasing digestive enzyme activities, and encouraging the digestion rate of energy nutrients ( 44 ). Moreover, treatment of infected birds (G6) with exogenous enzymes (amylase enzyme) might have both direct and indirect actions by providing a suitable environment for the endogenous digestive enzymes to act on the substrate, adjustment of the intestinal microbial populations, speed feed passage rate by increasing the hydrolytic GIT capacity and increasing the availability of macronutrients that are resistant to digestion by endogenous enzymes, leading to enhancement of nutrient solubility, digestibility and availability [40].…”

Section: Discussionmentioning

confidence: 99%

Modulatory effect of dietary probiotic and prebiotic supplementation on growth, immuno-biochemical alterations, DNA damage, and pathological changes in E. coli-infected broiler chicks

Hashem

Hassan²,

Abou-Elnaga³

et al. 2022

Front. Vet. Sci.

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Avian pathogenic Escherichia coli is one of the principal causes of heavy economic losses to the poultry industry. Little is known about the underlying mechanisms, particularly the potential role of immunoglobulin A and the DNA damage, involving the beneficial effects of dietary supplementation of probiotics and prebiotics in avian colibacillosis. The current study investigated the potential effects of probiotic and prebiotic dietary supplementation on E. coli-infected broiler chicks. A total of 120 1-day-old unsexed Hubbard chicks were divided into six groups: Group 1 was considered as a negative control; Group 2 was supplemented with 1 g/kg feed of Lactobacillus plantarum; Group 3 was supplemented with amylase enzyme; Group 4 served as a positive control infected orally by E. coli O78; Group 5 was supplemented with L. plantarum from 1-day-old chicken and then infected orally with E. coli O78; and Group 6 was supplemented with amylase enzyme from 1-day old chicken and then infected orally with E. coli O78. For all examined groups, the experimental period lasted for 42 days. The E. coli-infected group revealed a decrease in body performance parameters with a significant increase in the liver enzymes and renal function tests. The same group recorded a significant decrease in serum total proteins, albumins, and globulins, and the alteration of immunological parameters, antioxidant enzymes, oxidative stress parameters, and comet assay revealed highly damaged DNA in the liver and the intestine. By histopathological examination, a series of histopathological changes in the liver, the kidney, and the intestine were observed. The infected chick pretreated with probiotics or prebiotics demonstrated an improvement in body performance parameters besides a significant decrease in the hepatic enzymes and renal function tests. We noticed that, in treated groups, there was a significant increase in serum total proteins in the serum albumin and globulin levels, immunological parameters, and antioxidant enzymes. Furthermore, DNA damage and histopathological changes within hepatic, renal, and intestinal tissues were markedly diminished in the treated groups compared with the infected group. We concluded that the adverse effects of E. coli could be modulated through the chemopreventive administration of probiotics and prebiotics.

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“…In agricultural production, probiotics are already used as a feed additive in aquacultures [99], in chicken [100], pigs -Immune response modulation -Production of specific bioactive substances; endocrine and neurogenic effects [101], and cattle [102]. Research results on probiotic usage in livestock production, show positive growth response in animals and decreased E. coli and Clostridium amount, bacteria responsible for diarrheal diseases [103].…”

Section: Probiotics and Prebioticsmentioning

confidence: 99%

An Alternative to Antibiotics: Selected Methods to Combat Zoonotic Foodborne Bacterial Infections

Łojewska

Sakowicz

2021

Curr Microbiol

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Pathogenic bacteria contaminating food or animal feed cause serious economic losses in the health sector as well as is in the agriculture and food industry. The development of bacterial resistance due to the misuse of antibiotics and chemicals, especially in the farm industry, can bring dangerous effects for the global population therefore new safe biological antimicrobial solutions are urgently needed. In this paper, we investigate biological alternatives to antibiotics against foodborne pathogens. The most promising alternatives include antimicrobial proteins, bacteriophages, probiotics, and plant-based substances. Each described group of substances is efficient against specific foodborne bacteria and has a preferred use in an explicit application. The advantages and drawbacks of each method are outlined in the final section. Biological antibacterial solutions are usually easily degradable. In contrast to antibiotics or chemical/physical methods, they are also far more specific. When introducing new antibacterial methods it is crucial to check their safety and ability to induce resistance mechanisms. Moreover, it is important to assess its activity to inhibit or kill in viable but nonculturable cells (VBNC) state and biofilm forms. VBNC bacteria are considered a threat to public health and food safety due to their possibility of remaining viable and virulent. Biological alternatives to antibiotics complete the majority of the advantages needed for a safe and efficient antimicrobial product. However, further research is necessary to fully implement those solutions to the market.

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The use of probiotics to enhance immunity of broiler chicken against some intestinal infection pathogens

Cited by 7 publications

References 26 publications

Effects of Immune Modulators on the Immune Status of Broiler Chickens

Effects of Immune Modulators on the Immune Status of Broiler Chickens

Modulatory effect of dietary probiotic and prebiotic supplementation on growth, immuno-biochemical alterations, DNA damage, and pathological changes in E. coli-infected broiler chicks

An Alternative to Antibiotics: Selected Methods to Combat Zoonotic Foodborne Bacterial Infections

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