The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillofacial trauma

Herford, Alan S.

doi:10.1016/j.cjtee.2016.05.004

Cited by 21 publications

(13 citation statements)

References 27 publications

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“…Bone defects can result from trauma, malignancy, or congenital diseases and are a significant clinical problem. Trauma in the craniofacial region poses a great challenge to bone growth due to the location of highly important anatomic structures (Herford, ). Bone has a high capability to regenerate on its own with a three‐stage repair process.…”

Section: Introductionmentioning

confidence: 99%

Relaxin enhances bone regeneration with BMP‐2‐loaded hydroxyapatite microspheres

Injamuri

Rahaman

Yan

et al. 2020

J Biomedical Materials Res

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Our aims were to 1) evaluate the capacity of hollow hydroxyapatite (HA) microspheres (212–250 μm) to serve as a delivery system for controlled release of BMP‐2 in vitro and 2) examine relaxin as an enhancer of BMP‐2 for bone regeneration. Hollow HA microspheres were converted from borate glass microspheres and characterized using X‐ray diffraction, Fourier‐transform infrared spectroscopy, scanning electron microscopy, and the Brunauer–Emmett–Teller method. The microspheres loaded with BMP‐2 and relaxin were implanted for 6 weeks in Sprague Dawley rats with calvarial defects. BMP‐2 alone in the range up to 1 μg per defect exhibited dose‐dependent bone regeneration while relaxin alone in the range up to 0.25 μg per defect did not promote bone regeneration. When compared with BMP‐2 alone (1 μg per defect), a 50% reduction in the BMP‐2 dose was achieved with the addition of 0.05, 0.1, or 0.25 μg of relaxin per defect. These results show that loading HA microspheres with a combination of relaxin and BMP‐2 can significantly reduce the BMP‐2 dose required to regenerate an equivalent amount of bone.

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Section: Introductionmentioning

confidence: 99%

Relaxin enhances bone regeneration with BMP‐2‐loaded hydroxyapatite microspheres

Injamuri

Rahaman

Yan

et al. 2020

J Biomedical Materials Res

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show abstract

“…Additionally, rhBMP-2 is available as a therapeutic in anterior lumbar interbody fusion during spinal fusions within tapered cages [ 49 , 50 , 51 ]. rhBMP-2 has also been used during cranioplasty, especially following maxillofacial injury, to induce osteogenesis [ 224 ]. Because of the promising and well-known osteogenic potential of rhBMP-2, this therapeutic also seems ideal for osteoporotic and osteoarthritic patients.…”

Section: Clinical Applications and Limitations Of Bmp-2mentioning

confidence: 99%

“…Normally, there are 2 mg of BMP-2 in circulation and use in the human body. INFUSE uses 40mg of BMP-2 in order to promote its positive osteogenic effects [ 224 , 225 ]. However, the amount of BMP-2 used causes life-threatening complications through swelling in the neck.…”

Section: Clinical Applications and Limitations Of Bmp-2mentioning

confidence: 99%

Bone Morphogenetic Protein-2 in Development and Bone Homeostasis

Halloran

Durbano

Nohe

2020

JDB

191

139

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Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Specifically, within the BMP family, Bone Morphogenetic Protein-2 (BMP-2) was the first BMP to be characterized and has been well-studied. BMP-2 has important roles during embryonic development, as well as bone remodeling and homeostasis in adulthood. Some of its specific functions include digit formation and activating osteogenic genes, such as Runt-Related Transcription Factor 2 (RUNX2). Because of its diverse functions and osteogenic potential, the Food and Drug Administration (FDA) approved usage of recombinant human BMP-2 (rhBMP-2) during spinal fusion surgery, tibial shaft repair, and maxillary sinus reconstructive surgery. However, shortly after initial injections of rhBMP-2, several adverse complications were reported, and alternative therapeutics have been developed to limit these side-effects. As the clinical application of BMP-2 is largely implicated in bone, we focus primarily on its role in bone. However, we also describe briefly the role of BMP-2 in development. We then focus on the structure of BMP-2, its activation and regulation signaling pathways, BMP-2 clinical applications, and limitations of using BMP-2 as a therapeutic. Further, this review explores other potential treatments that may be useful in treating bone disorders.

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“…When genome sequencing and cloning became widely available in the 1980s, rhBMPs (rhBMP-2 and rhBMP-7) became extensively used in craniomaxillofacial and orthopedic trauma to enhance healing through a complex cascade of cellular recruitment and differentiation events. [23][24][25] Supported by multiple randomized controlled trials, rhBMP-2 on an ACS has been approved by the US Food and Drug Administration (FDA) for use in a number of applications, including the enhancement of spinal fusion procedures, treatment of acute open tibial shaft fracture, and augmentation of the maxillary sinus and localized alveolar ridge defects due to dental extraction. 26,27 A concentration of 1.5 mg/mL of rhBMP-2/ACS was identified as the most effective concentration.…”

Section: E20mentioning

confidence: 99%

Is Reconstruction of Large Mandibular Defects Using Bioengineering Materials Effective?

Melville

Tran

Bhatti

et al. 2020

Journal of Oral and Maxillofacial Surgery

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The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillofacial trauma

Cited by 21 publications

References 27 publications

Relaxin enhances bone regeneration with BMP‐2‐loaded hydroxyapatite microspheres

Relaxin enhances bone regeneration with BMP‐2‐loaded hydroxyapatite microspheres

Bone Morphogenetic Protein-2 in Development and Bone Homeostasis

Is Reconstruction of Large Mandibular Defects Using Bioengineering Materials Effective?

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