The Use of Retinoids in the Pediatric Patient

Ichthyosis follicularis, alopecia and photophobia syndrome (IFAP): report of the first case with ocular and cutaneous manifestations in Brazil with a favorable response to treatment

“…There are reported cases of mental retardation, epilepsy and other neurological findings (4) . Retinoids, such as Acitretin, have been used in genetic disorders from keratinization in children (7) due to action in the mechanisms of cell proliferation and differentiation. Different aspects of the favorable clinical response occurred, in average, after the third month of the beginning of the treatment (8) .…”

Off-label uses of retinoids in dermatology

“…Body height and weight were chosen as the monitoring indexes to evaluate the growth and development and other common side effects as the safety evaluation of the children for a follow-up of 2-36 months. Acitretin showed a satisfactory therapeutic effect on severe inherited disorders of keratinization in children [59,69,183,184].…”

“…In chronic cases, a maintenance dosage (0.3 to 1 mg/kg/ day) during 4 to 6 months is required. Generally, no severe relapses occur for a longer period of time after the end of therapy [59,188,189]. …”

“…Lesions slowly clear, even in cases resistant to conventional therapies. A maintenance dosage of 0.20 to 0.50 mg/kg/day is generally sufficient to keep the patient controlled with the minimum long-term side effects [59,189].…”

Childhood Psoriasis

“…Asitretin'in etkinliği genellikle 3. veya 4. haftada ortaya çıkar. Remisyon sağlandığında doz yavaşça azaltılarak, en az 0,2 mg/kg olacak şekilde yaklaşık 2 ay süre ile idame tedavisi uygulanmalıdır 52 . Keilit, deride kaşıntı ve soyulma, kas ağrısı, iskelet toksisitesi, serum lipitlerinde ve karaciğer enzimlerinde yükselme ve psödotümör serebri yan etkileridir ve monitorize edilmelidir.…”