The Use of Ritodrine in the Treatment of Premature Labour

Rénaud, R; Irrmann, M; Gandar, R; Flynn, Michael J.

doi:10.1111/j.1471-0528.1974.tb00443.x

Cited by 44 publications

(3 citation statements)

References 7 publications

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“…This relaxing ß action of catecholamines is exploited by most obstetricians: ß adrenergic agents (ritodrine, metaproterenol, isoxsuprine, etc.) are used to arrest a threatening pre¬ mature labour (Renaud, Irrmann, Gandar & Flynn, 1974). This ß action of catecholamines is blocked by propranolol which increases the contractility and reactivity of gravid myo¬ metrium (in rats: Maughan et al 1967;Shabanah et al 1968;Raz, Zeigler & Adoni, 1971 ; in man: Wansbrough, Nakanishi <& Wood, 1968;Andersson, Ingemarsson & Persson, 1973).…”

Section: Discussionmentioning

confidence: 99%

Effects of Injections of Monoamine Oxidase Inhibitor or Saline Into the Uterus in Late Pregnancy on Uterine Catecholamine Levels Related to Abnormal Parturition in Rats

Maltier¹,

Cavaillé²

1975

Journal of Endocrinology

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Injection of a monoamine oxidase (MAO) inhibitor (nialamide) into the uterus of an anaesthetized and laparotomized rat on day 20 of pregnancy severely disturbed parturition. Injection of the solvent (0-9% isotonic NaCl solution) at the same stage of gestation produced the same but less frequent disturbances. When the rats were injected on days 19 or 21, impairment was less marked than on day 20. Therefore, day 20 seems to be a critical period for the onset of parturition. Injection of Ringer solution into the uterus on day 20 had effects analogous to those of saline injection at the same stage. Anaesthesia induced with ether, laparotomy of the pregnant rat on day 20, and handling of the uterine horns without injection of either Ringer or NaCl also disturbed parturition in 70% of the rats treated. Nevertheless, disorders were not as severe as those after injection. Laparotomy alone on day 20 did not disturb parturition. The effects on parturition of a saline injection into the uterus on day 20 were greatly decreased when the injection was performed on pregnant rats adrenalectomized on day 14, or on pregnant rats pretreated on days 18 and 19 with an agent blocking the adrenergic beta receptors (propranolol); 70-80% of the treated rats had normal deliveries. In control rats, uterine catecholamine levels were markedly modified between days 21 and 22 of gestation. These changes did not occur in rats injected with MAO inhibitor or saline.

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Section: Discussionmentioning

confidence: 99%

Effects of Injections of Monoamine Oxidase Inhibitor or Saline Into the Uterus in Late Pregnancy on Uterine Catecholamine Levels Related to Abnormal Parturition in Rats

Maltier¹,

Cavaillé²

1975

Journal of Endocrinology

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“…There are numerous second generation /I-sympathomimetic drugs available to fulfil this function (Renaud et al, 1974;Wilson and Fuchs, 1975;De Villiers, 1975;McDevitt et al, 1975;Anderson et al, 1975), but they have to be given intravenously to obtain a rapid onset of action, they are consequently not available to the patient at home, nor to outlying midwife obstetric units with no doctor in attendance where delay in treatment results in an increased morbidity and mortality. There are numerous second generation /I-sympathomimetic drugs available to fulfil this function (Renaud et al, 1974;Wilson and Fuchs, 1975;De Villiers, 1975;McDevitt et al, 1975;Anderson et al, 1975), but they have to be given intravenously to obtain a rapid onset of action, they are consequently not available to the patient at home, nor to outlying midwife obstetric units with no doctor in attendance where delay in treatment results in an increased morbidity and mortality.…”

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confidence: 99%

The Effects of the Fenoterol Hy Drobromide (Partusisten) Aerosol on Uterine Activity and the Cardiovascular System

Lipshitz¹,

Baillie²

1976

BJOG

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AND SummaryFenoterol hydrobromide (Partusisten) aerosol was used in a placebo-controlled, double-blind, double crossover trial to study its effects on oxytocin-induced uterine contractions and the maternal cardiovascular system. The active and placebo aerosols were each administered a total of ten times or twice each in five patients who were in established oxytocin-induced labour with intact membranes. Five puffs, of 200 pg each, of the active aerosol reduced uterine activity by more than half; the effect on the cardiovascular system was to cause a mild tachycardia and to widen the pulse pressure.

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“…It is used as an uterine relaxant in treatment of premature labor [1,5,6], Efficient tocolytic action is obtained in 80-90% of the cases as reported since the last 10 years. The drug can be administered in three ways: orally, intramuscularly, and intraveneously.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Ritodrine Radioimmunoassay

Thomas¹,

Vankrieken²,

Vanlierde³

1982

Gynecol Obstet Invest

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A sensitive and specific radioimmunoassay method was developed for the determination of ritodrine in human serum. Cross-reactions with four other Β-sympathomimetic drugs, various peptides, and steroid hormones were checked. Serum ritodrine levels were assayed in 8 healthy nonpregnant female volunteers after either oral or intramuscular administration of 10 mg ritodrine. Peak serum ritodrine levels were found at 45 min after oral administration and at 15 min after intramuscular injection.

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The Use of Ritodrine in the Treatment of Premature Labour

Cited by 44 publications

References 7 publications

Effects of Injections of Monoamine Oxidase Inhibitor or Saline Into the Uterus in Late Pregnancy on Uterine Catecholamine Levels Related to Abnormal Parturition in Rats

Effects of Injections of Monoamine Oxidase Inhibitor or Saline Into the Uterus in Late Pregnancy on Uterine Catecholamine Levels Related to Abnormal Parturition in Rats

The Effects of the Fenoterol Hy Drobromide (Partusisten) Aerosol on Uterine Activity and the Cardiovascular System

Characterization of Ritodrine Radioimmunoassay

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