A sensitive and specific radioimmunoassay method was developed for the determination of ritodrine in human serum. Cross-reactions with four other Β-sympathomimetic drugs, various peptides, and steroid hormones were checked. Serum ritodrine levels were assayed in 8 healthy nonpregnant female volunteers after either oral or intramuscular administration of 10 mg ritodrine. Peak serum ritodrine levels were found at 45 min after oral administration and at 15 min after intramuscular injection.
A patient presented with mild upper airway obstruction after being shot from behind through the neck and soft palate. Two days later he developed palsies of the IXth to XIIth cranial nerves inclusive on the traumatised side. These palsies resolved spontaneously after three weeks. Further investigation revealed the presence of a saccular aneurysm of the internal carotid artery. The internal carotid artery was ligated after gradual closure for three days using a Preston clamp.
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