2014
DOI: 10.4161/21659087.2014.984509
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The Use of Second Harmonic Generation to Image the Extracellular Matrix During Tumor Progression

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Cited by 23 publications
(19 citation statements)
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“…In addition, we further investigated the expression of MMPs ( Figure ), enzymes responsible for matrix degradation that have been shown to play a significant role in tumor progression . Indeed, the paracrine signaling among cancer cells and fibroblasts induce the latter in producing MMPs, that in turn can aid the migration of cancer cells the 3D environment.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…In addition, we further investigated the expression of MMPs ( Figure ), enzymes responsible for matrix degradation that have been shown to play a significant role in tumor progression . Indeed, the paracrine signaling among cancer cells and fibroblasts induce the latter in producing MMPs, that in turn can aid the migration of cancer cells the 3D environment.…”
Section: Resultsmentioning
confidence: 99%
“…Multiphoton microscopy and SHG are widely used in clinical applications as potential diagnostic parameters. In particular, SHG signal gets information concerning both the collagen composition and its structural modifications due to the transition of fibroblasts from a healthy to an activated state . In Figure A–C is reported the quantification of the ECM components: fibronectin (Figure A), HA (Figure B), and collagen (Figure C) in NF‐, CAF‐, and AC‐μTP.…”
Section: Resultsmentioning
confidence: 99%
“…Previous studies also have shown that inhibition of LOX activity reduces the abundance of linear collagen fibrils associated with tumors (30). Using second harmonic generation imaging microscopy (30)(31)(32), we investigated whether the loss of ATP7A reduced collagen fibril assembly in primary tumors and metastatic lung nodules. As expected, tumor-associated collagen was predominantly organized in long linear arrangements (>30 μm) in 4T1-WT tumors, but in C3/ATP7A− derived tumors, the collagen fibrils were significantly shorter and exhibited an overall reduced linear organization (SI Appendix, Fig.…”
Section: Atp7a Deletion In 4t1 Breast Cancer Cells Attenuates Tumor Gmentioning
confidence: 99%
“…It has been shown that the imaging tests before surgery such as CT and MRI were not suitable for the detection of micrometastases and nodules (< 5 mm) (17); due to the in ltration of cancer tissues, lack of differentiation, nerve involvement and complex veins. The characteristics of the tube system and other characteristics are based on the surgeon's inspection and palpation, leading to a signi cant tumor residual rate (exceeding 50%) (18). Through the high permeability and high retention (EPR) effect of tumor tissue, uorescent dyes can accumulate in tumor tissue, NIRF imaging system could provide high tumor background signal ratio using large amounts of ICG, thereby helping surgeons to effectively localize tumors.…”
Section: Discussionmentioning
confidence: 99%