The use of stool specimens reveals Helicobacter pylori strain diversity in a cohort of adolescents and their family members in a developed country

Dolan, Brendan; Burkitt-Gray, Lucy; Shovelin, Stephen; Bourke, Billy; Drumm, Brendan; Rowland, Marion; Clyne, Marguerite

doi:10.1016/j.ijmm.2017.11.005

Cited by 20 publications

(13 citation statements)

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“…A relatively small cross-sectional study was recently reported in Turkey confirming the previous evidence of more frequent infection in larger families with other infected members. 28 Similar H pylori strains were most commonly found in both mothers and children and in siblings; 40% of the individuals had multiple strains, and several individuals harbored strains not found in other family members. 28 Similar H pylori strains were most commonly found in both mothers and children and in siblings; 40% of the individuals had multiple strains, and several individuals harbored strains not found in other family members.…”

Section: Family Transmission and Interaction With Other Microbiotamentioning

confidence: 92%

“…27 A H pylori stool DNA-based study on 50 individuals in 13 families was reported from Ireland. 28 Similar H pylori strains were most commonly found in both mothers and children and in siblings; 40% of the individuals had multiple strains, and several individuals harbored strains not found in other family members. The same study group concluded that spontaneous H pylori clearance is uncommon in adolescents or adulthood in developed countries 29 ; however, it should be mentioned that the prevalence of the infection was low in this study population.…”

Section: Family Transmission and Interaction With Other Microbiotamentioning

confidence: 92%

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Review: Epidemiology of Helicobacter pylori infection

et al. 2019

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This review summarizes recent publications on the epidemiology of Helicobacter pylori. Two major systemic analyses, from Malaysia and Ethiopia, were published. The Brazilian Consensus Conference has stated that H pylori infection is an infectious disease with an indication for antimicrobial therapy. A continuous decrease in H pylori prevalence was reported from many regions worldwide, including Korea, China, Iran, and Austria. A cross‐sectional H pylori prevalence study conducted in the United Arab Emirates found 41% prevalence in a group of healthy children and adults. Several studies from Asia addressed H pylori prevalence in adults undergoing regular checkup. The largest of such studies, performed in Korea, involved 24 471 subjects and reported 41.5% seroprevalence. A relatively smaller study from East China on 3252 subjects reported 27.5% prevalence. In contrast, a study from Spain reported 87.2% seroprevalence. A report on the association between smoking and H pylori seropositivity was published on behalf of the Stomach Cancer Pooling (StoP) Project—a consortium of epidemiological studies of gastric cancer. Also, other potential risk factors, including occupational risk factors, water supply, and food were analyzed. Gastroesophageal reflux and sexual partners has been associated with a higher risk for H pylori acquisition, and gut microbiota was suggested to play a role in intrafamilial transmission of H pylori. Finally, in a few studies (from Mexico and Japan), the catalytic model for predicting the potential risk of acquiring H pylori infection in the future was used. As anticipated, a further decline in H pylori‐related disease was demonstrated by applying the modeling.

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Section: Family Transmission and Interaction With Other Microbiotamentioning

confidence: 92%

Section: Family Transmission and Interaction With Other Microbiotamentioning

confidence: 92%

Review: Epidemiology of Helicobacter pylori infection

et al. 2019

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“…Another study from Ireland analyzed fecal samples of all family members by PCR for H. pylori typing (n = 82) if a child and at least one family member were H. pylori positive by UBT. Although in the majority of cases, children had a similar strain to that of their mothers and siblings, multiple strain infection was demonstrated in a high proportion (37.7%) of individuals, thus suggesting that even in industrialized countries, H. pylori could be acquired outside the family …”

Section: Epidemiologymentioning

confidence: 99%

“…Although in the majority of cases, children had a similar strain to that of their mothers and siblings, multiple strain infection was demonstrated in a high proportion (37.7%) of individuals, thus suggesting that even in industrialized countries, H. pylori could be acquired outside the family. 3…”

Section: Studied H Pylori Incidence Inmentioning

confidence: 99%

Helicobacter pyloriand some aspects of gut microbiota in children

2018

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Helicobacter pylori infection in children differs from infection in adults in many aspects. The rate of infection, epidemiology, clinical presentations and complications, the applicability of diagnostic tests, antibiotic resistance, treatment options, and success rates differ significantly. Due to all these differences, management guidelines for children and adults differ also substantially. In 2017, the Updated ESPGHAN and NASPGHAN Guidelines on the management of H. pylori infection in children were published, emphasizing the differences in clinical presentation and indications for treatment, stating that the primary goal of clinical investigation in children is to identify the cause of upper gastrointestinal symptoms rather than the presence of H. pylori infection. Therefore, the diagnosis should be based on upper endoscopy, and the "test and treat strategy" should not be used in children. Due to an increasing rate of antibiotic resistance worldwide, the updated guidelines recommend broader use of antimicrobial susceptibility testing for H. pylori strains in order to tailor eradication treatment accordingly. Moreover, treatment in children should be prescribed only when indicated and should be based on the rate of eradication in local populations aiming for treatment success above 90%. During the last two decades there has been a steady decrease in the rate of H. pylori infection in both children and adults in the Western world. Two recent publications studying the incidence of H. pylori infection confirmed that early childhood is a time for acquisition of infection both in industrialized and nonindustrialized countries. In addition, they showed that H. pylori could be acquired outside the family. In respect to the inverse association between H. pylori and allergy, a longitudinal study demonstrated that early exposure to H. pylori at any age was inversely associated with atopy and allergic conditions.

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“…pylori ha sido cultivado a partir de heces de individuos infectados (Thomas et al, 1992;Kelly et al, 1994;Falsafi et al, 2007), existiendo cada vez más evidencias que sugieren una ruta de transmisión fecal-oral para H. pylori (Mladenova et al, 2006). Sin embargo, esta ruta sigue siendo cuestionada, ya que la concentración de H. pylori en las heces es considerada baja, particularmente cuando se compara con la de otros patógenos fecales de importancia en la salud pública (Dolan et al, 2018). Además, el cultivo de H. pylori a partir de heces se ha conseguido en muy pocas ocasiones, aunque la presencia de sus antígenos y su DNA en heces de individuos infectados es un hecho común (Ford y Axon, 2010).…”

Section: Modo De Transmisiónunclassified

Estudio del papel de las amebas de vida libre como reservorio de Helicobacter pylori y otras bacterias patógenas en aguas y alimentos mediante técnicas moleculares

Mesonero¹

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En primer lugar me gustaría agradecer a mis directoras de Tesis, Mª Antonia Ferrús y Yolanda Moreno, el haber confiado en mí para llevar a cabo este gran reto. Gracias por guiarme en la realización de este trabajo, por todo vuestro tiempo, esfuerzo, dedicación, y, lo más importante, transmitirme vuestra pasión por la investigación. Creedme que se contagia. Gracias también al Instituto de Ingeniería del Agua y Medio Ambiente, por acogerme como una más desde el primer día. Siempre me he sentido como en casa, y, así, las cosas son mucho más fáciles. En especial a José Luis y a Inma, que siempre han tenido tiempo para explicarme y ayudarme en cualquier cosa o, simplemente, hablar de la vida. Junto con Yolanda, quiero agradeceros el haber confiado en mí para participar en los proyectos de investigación. He aprendido muchísimo, siempre de vuestra mano. Muchas gracias también por haberme permitido viajar con vosotros a los diferentes congresos y reuniones de proyectos, ya que así he podido conocer otra parte de la investigación. Sin vuestra predisposición no hubiera sido posible. También quisiera agradecer a todos los compañeros de laboratorio que me han acompañado durante este camino. Julián, Andrés, Patri, Irene Hortelano, Irene Cañigral, Paula Santiago, Paula Barbarroja, Fidson, Mariela y todos aquellos que habéis pasado por el IIAMA. Sin vosotros esta aventura no hubiera sido igual. En especial a Julián, sabes que me llevo un gran amigo. Por último, me gustaría agradecer a mi familia todo el apoyo incondicional que me han dado siempre. En especial a mi madre y a mi hermana, que siempre me han apoyado aunque no entiendan muy bien lo que hago con los bichitos. Y, como no, a Carlos, mi marido, por apoyarme incondicionalmente siempre, por tu paciencia, tus ánimos, por entender mis largos días frente al ordenador, y, sobre todo, por creer en mí. Un trocito de de este trabajo es tuyo, lo sabes. Durante la tesis hemos vivido juntos muchos cambios, cambios muy bonitos y muy felices. Y, para que así siga siendo, te la dedico a ti. Resum VI RESUM L'increment de la població i l'escassetat de recursos hídrics naturals a causa de l'escassa pluviometria irregularment distribuïda en el temps, com ocorre en les regions mediterrànies, fan necessària la reutilització de les aigües residuals. Abans de ser tractades, estes aigües contenen matèria orgànica que oferix un substrat idoni per al desenrotllament de qualsevol classe de microorganismes, molts dels quals són patògens. D'altra banda, l'aigua potable s'obté a partir d'aigua natural o crua captada en rius, llacunes, pous, brolladors o pantans, les quals també poden contindre microorganismes patògens. A causa d'açò, és de la màxima importància realitzar un correcte tractament d'esta aigua per tal d'evitar la transmissió de malalties. D'entre tots els patògens emergents en aigües, H. pylori és un de què major interés desperta en estos moments, ja que la seua epidemiologia encara no està clara. La infecció per H. pylori pot conduir al desenrotllament de gastritis crònica, úlcera pèpt...

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The use of stool specimens reveals Helicobacter pylori strain diversity in a cohort of adolescents and their family members in a developed country

Cited by 20 publications

References 50 publications

Review: Epidemiology of Helicobacter pylori infection

Review: Epidemiology of Helicobacter pylori infection

Helicobacter pyloriand some aspects of gut microbiota in children

Estudio del papel de las amebas de vida libre como reservorio de Helicobacter pylori y otras bacterias patógenas en aguas y alimentos mediante técnicas moleculares

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