The use of superporous Ac-CGGASIKVAVS-OH-modified PHEMA scaffolds to promote cell adhesion and the differentiation of human fetal neural precursors

Kubinová, Šárka; Horák, Daniel; Kozubenko, Nataliya; Vaněček, Václav; Proks, Vladimír; Price, John; Cocks, Graham; Syková, Eva

doi:10.1016/j.biomaterials.2010.04.040

Cited by 91 publications

(86 citation statements)

References 28 publications

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“…Several other research groups have also undertaken similar approaches since the publication of the Park study (Bible et al, 2009;Kubinova et al, 2010). What is envisioned by these scientists pursuing a 'stem cell plus' approach is an implantable 'device', part biological, part synthetic (Orive et al, 2009).…”

Section: Stem Cell Transplantation Strategiesmentioning

confidence: 95%

Reconstructing brains: A biological impossibility?

Price

2011

BioSocieties

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The reconstruction of damaged brain tissue is desirable because brain damage constitutes a major area of unmet medical need. In the view of some advocates, the cell therapy approaches that will lead to the reconstruction of damaged brain tissue will also enhance brain function in normal people. Although the meeting of unmet medical need appears laudable, human enhancement is viewed by some as a threat, but is brain reconstruction achievable whether desirable or not? This article argues that the prospects for true regenerative medicine in the brain are considerably exaggerated. Although current studies may lead to clinical advancement, progress on true reconstruction is very limited. I argue that brain reconstruction might prove to be an example of genuine biological impossibility.

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Section: Stem Cell Transplantation Strategiesmentioning

confidence: 95%

Reconstructing brains: A biological impossibility?

Price

2011

BioSocieties

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“…15 Specific examples include the enhancement of angiogenic processes using FGF-2/VEGF-sequestering heparinized PEG hydrogels 16 and improved adhesion and differentiation of human fetal neural precursor cells on IKVAV peptide-containing poly-HEMA hydrogels. 17 Another important potential function of biomimetic matrices is the control of ECM assembly at the cell-biomaterial interface, as has been demonstrated by incorporation of an osteocalcin functional domain that enhanced incorporation of hydroxyapatite in engineered bone constructs. 14…”

Section: Trying To Mimic the Smartest Matrixmentioning

confidence: 98%

Smart Matrices for Distal Lung Tissue Engineering

Mondrinos¹,

Lelkes²

2015

Stem Cells, Tissue Engineering and Regenerative Medicine

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“…This strategy involves the copolymerization of HEMA with 2-aminoethyl methacrylate (AEMA), which displays an amino function usable for the subsequent attachment of peptides of interest [32,33]. In particular, in recent studies of Kubinova et al, the P(HEMAco-AEMA) hydrogel was reacted with g-thiobutyrolactone to introduce thiol groups (SH), which after activation with 2,2 0 -dithiodipyridine (TPy) immobilized the Ac-CGGASIKVAVS sequence via the SH groups of cysteine ( Fig.…”

Section: Bioadhesion Promoting Strategiesmentioning

confidence: 99%

Recent advances in synthetic polymer based hydrogels for spinal cord repair

Trimaille

Perreten

Gigmès

2015

Comptes Rendus. Chimie

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International audienceIn spinal cord repair, the challenge consists in combining various therapies that account for multiple deleterious effects in order to induce an efficient recovery. In that context, biomaterial implantation seems to be highly relevant. Indeed, biomaterials not only serve as a growth support to promote sectioned axonal fibers, but are also used for cell transplantation and drug delivery. In this review, we discuss and put into perspective the recent results obtained in the field of spinal cord repair by synthetic hydrogel implantation. The versatility of those biomaterials is presented through the latest chemical strategies developed to enhance their therapeutic effects. (C) 2015 Academie des sciences. Published by Elsevier Masson SAS. This is an open access article under the CC BY-NC-ND license

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The use of superporous Ac-CGGASIKVAVS-OH-modified PHEMA scaffolds to promote cell adhesion and the differentiation of human fetal neural precursors

Cited by 91 publications

References 28 publications

Reconstructing brains: A biological impossibility?

Reconstructing brains: A biological impossibility?

Smart Matrices for Distal Lung Tissue Engineering

Recent advances in synthetic polymer based hydrogels for spinal cord repair

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