The use of the Durbin-Watson statistic for testing the validity of kinetic models for dissolution

“…The release data were analyzed at time intervals of 30 min (90% c.i. ).The extent of linearity of release profiles was evaluated through the Durbin-Watson statistics (Durbin and Watson, 1950;Van der Voet et al, 1983) (Durbin andWatson, 1950) (Van der Voet et al, 1983). The release data were analyzed at time intervals of 30 min (90% c.i.…”

Section: Release Studiesmentioning

confidence: 99%

Cellulase as an “active” excipient in prolonged-release HPMC matrices: A novel strategy towards zero-order release kinetics

Palugan

Filippin

Cirilli

et al. 2021

International Journal of Pharmaceutics

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“…The extent of linearity of release profiles was evaluated through the Durbin-Watson statistics, which enables to identify zero-order portions in each curve (Durbin and Watson, 1950;van der Voet et al, 1983) .…”

Section: Release Testing and Data Analysis Of Layered And Tableted Ma...mentioning

confidence: 99%

Non-uniform drug distribution matrix system (NUDDMat) for zero-order release of drugs with different solubility

Cerea

Foppoli

Palugan

et al. 2020

International Journal of Pharmaceutics

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“…The extent of linearity of release profiles was evaluated through the Durbin-Watson statistics, which enables to identify zero-order portions in each curve [42,44,45]. The release data were analyzed at time intervals of 1 h, between 0.05 and 0.90 fractions released (90% c.i.…”

Section: Release Testing Of Tableted and Layered Units And Data Analysismentioning

confidence: 99%

Novel hydrophilic matrix system with non-uniform drug distribution for zero-order release kinetics

Cerea

Maroni

Palugan

et al. 2018

Journal of Controlled Release

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A decrease in the release rate over time is typically encountered when dealing with hydrophilic matrix systems for oral prolonged release due to progressive increase of the distance the drug molecules have to cover to diffuse outwards and reduction of the area of the glassy matrix at the swelling front. In order to solve this issue, a novel formulation approach based on non-uniform distribution of the active ingredient throughout the swellable polymer matrix was proposed and evaluated. Various physical mixtures of polymer (high-viscosity hypromellose) and drug tracer (acetaminophen), having decreasing concentrations of the latter, were applied by powder-layering onto inert core seeds. The resulting gradient matrices showed to possess satisfactory physico-technological characteristics, with spherical shape and consistent thickness of the layers sequentially applied. The non-uniform matrix composition pursued was confirmed by Raman mapping analysis. As compared with a system having uniform distribution of the drug tracer, the multi-layer formulations were proved to enhance linearity of release. The simple design concept, advantageous technique, which involves no solvents nor high-impact drying operations, and the polymeric material of established use make the delivery platform hereby proposed a valuable strategy to improve the performance of hydrophilic matrix systems.

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The use of the Durbin-Watson statistic for testing the validity of kinetic models for dissolution

Cited by 7 publications

References 8 publications

Cellulase as an “active” excipient in prolonged-release HPMC matrices: A novel strategy towards zero-order release kinetics

Cellulase as an “active” excipient in prolonged-release HPMC matrices: A novel strategy towards zero-order release kinetics

Non-uniform drug distribution matrix system (NUDDMat) for zero-order release of drugs with different solubility

Novel hydrophilic matrix system with non-uniform drug distribution for zero-order release kinetics

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