The use of titanium implants and prosthodontic techniques in the preparation of non-human primates for long-term neuronal recording studies

Betelak, Kathleen F.; Margiotti, E.A.; Wohlford, Mark E.; Suzuki, David

doi:10.1016/s0165-0270(01)00442-3

Cited by 28 publications

(21 citation statements)

References 13 publications

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“…Titanium headposts have been used successfully in monkeys, however, the majority of these implants did not involve any surface modifications nor were the topographic characteristics of the surface reported (Betelak et al, 2001;Adams et al, 2007). Titanium has also been recently used to construct chambers for acute electrophysiological recordings (Adams et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…The metal headpost is an indispensable skullanchored implant employed to eliminate head movements that may contaminate neural recordings or measurements of eye position. Although the configuration and the material of headposts have been improved throughout the last decade (Pfingst et al, 1989;Betelak et al, 2001;Adams et al, 2007;Davis et al, 2009), the loss of headpost fixation to the skull remains a factor. For example, an informal survey of five laboratories that use metal headposts suggested a 5-10% failure rate due to a lack of integration with the skull bone.…”

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confidence: 99%

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Surface roughness enhances the osseointegration of titanium headposts in non-human primates

Hacking¹,

Boyraz²,

Powers³

et al. 2012

Journal of Neuroscience Methods

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Surface roughness enhances the osseointegration of titanium headposts in non-human primates

Hacking¹,

Boyraz²,

Powers³

et al. 2012

Journal of Neuroscience Methods

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“…Preparation for single-unit recording involved the implanting of special titanium inserts into the skull and the attachment of a prefab-ricated, hardware containing acrylic skull cap as described in detail in Betelak et al (2001). Employing this improved method for more than 6 yr has resulted in zero implant failures.…”

Section: Preparationmentioning

confidence: 99%

Smooth-Pursuit Eye-Movement-Related Neuronal Activity in Macaque Nucleus Reticularis Tegmenti Pontis

Suzuki

Yamada²,

Yee³

2003

Journal of Neurophysiology

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. Smoothpursuit eye-movement-related neuronal activity in macaque nucleus reticularis tegmenti pontis. J Neurophysiol 89: 2146 -2158, 2003; 10.1152/jn.00117.2002. Neuronal responses that were observed during smooth-pursuit eye movements were recorded from cells in rostral portions of the nucleus reticularis tegmenti pontis (rNRTP). The responses were categorized as smooth-pursuit eye velocity (78%) or eye acceleration (22%). A separate population of rNRTP cells encoded static eye position. The sensitivity to pursuit eye velocity averaged 0.81 spikes/s per°/s, whereas the average sensitivity to pursuit eye acceleration was 0.20 spikes/s per°/s 2 . Of the eye-velocity cells with horizontal preferences for pursuit responses, 56% were optimally responsive to contraversive smooth-pursuit eye movements and 44% preferred ipsiversive pursuit. For cells with vertical pursuit preferences, 61% preferred upward pursuit and 39% preferred downward pursuit. The direction selectivity was broad with 50% of the maximal response amplitude observed for directions of smooth pursuit up to Ϯ85°away from the optimal direction. The activities of some rNRTP cells were linearly related to eye position with an average sensitivity of 2.1 spikes/s per deg. In some cells, the magnitude of the response during smooth-pursuit eye movements was affected by the position of the eyes even though these cells did not encode eye position. On average, pursuit centered to one side of screen center elicited a response that was 73% of the response amplitude obtained with tracking centered at screen center. For pursuit centered on the opposite side, the average response was 127% of the response obtained at screen center. The results provide a neuronal rationale for the slow, pursuit-like eye movements evoked with rNRTP microstimulation and for the deficits in smooth-pursuit eye movements observed with ibotenic acid injection into rNRTP. More globally, the results support the notion of a frontal and supplementary eye field-rNRTP-cerebellum pathway involved with controlling smooth-pursuit eye movements. I N T R O D U C T I O NSmooth-pursuit eye movements are frequently generated to keep our attention focused on moving objects of interest. Visual motion information is utilized in initiating and maintaining this tracking behavior. Thus one cortico-ponto-cerebellar pathway of import to the control of smooth-pursuit eye movements routes visual motion and visuo-oculomotor signals from middle temporal/medial superior temporal (MT/MST) to the dorsolateral pontine nucleus (DLPN) and thence to ocular motorrelated parts of the cerebellum (e.g., Brodal

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“…Critical to our approach was ready access to MR and CT scanning facilities, along with logistical and technical support, which allowed us to generate 3D models of our animals’ anatomy. An alternative strategy is to carry out a surgical survey, in which the skin is temporarily retracted and a mould is taken of the skull, forming the basis for future modelling (Betelak et al, 2001). However, obtaining a cast of the skull is labour-intensive and time-consuming.…”

Section: Discussionmentioning

confidence: 99%

3D printing and modelling of customized implants and surgical guides for non-human primates

Chen

Possel

Wacongne

et al. 2017

Journal of Neuroscience Methods

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The use of titanium implants and prosthodontic techniques in the preparation of non-human primates for long-term neuronal recording studies

Cited by 28 publications

References 13 publications

Surface roughness enhances the osseointegration of titanium headposts in non-human primates

Surface roughness enhances the osseointegration of titanium headposts in non-human primates

Smooth-Pursuit Eye-Movement-Related Neuronal Activity in Macaque Nucleus Reticularis Tegmenti Pontis

3D printing and modelling of customized implants and surgical guides for non-human primates

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