The Use of Tocopherols in the Treatment of Peyronie's Disease

Pathophysiology of Peyronie's disease

“…As described briefly earlier, it has been hypothesized that oxidative damage may be causal in the initiation and progression of tissue fibrosis. 36 While there is limited reported efficacy and no double blinded trials, both para-aminobenzoic acid 37 and vitamin E 38 have been reported as a treatment of Peyronie's disease. Intraplaque injection of the anti-inflammatory protein orgotein 39 -42 which has superoxide dismutase activity or bovine superoxide dismutase 43 are reported to improve symptoms in Peyronie's patients, although adequate clinical trials are lacking.…”

Role of oxidative stress and antioxidants in Peyronie's disease

“…High doses of vitamin E have been used in Peyronie's patients but without much success. 49 Selenium is an important component of glutathione peroxidase and may show additional benefit when combined with vitamin E in preventing=treating certain cases of Peyronie's disease. Although therapeutic use of such antoxidants appears attractive, further controlled clinical studies will determine if many of these putative antioxidants can prevent plaque formation in selected groups of patients.…”

Tratamiento conservador de la enfermedad de Peyronie: colchicina versus colchicina más vitamina E

“…La vitamina E, por sus efectos antioxidantes y antifibró ticos, es comú nmente usada para tratar la EP a partir de que Scott y Scardino reportaron su beneficio 10,11 . Muchos clínicos la consideran como un fá rmaco barato y virtualmente inocuo.…”