The use of zebrafish model in prostate cancer therapeutic development and discovery

Amawi, Haneen; Aljabali, Alaa A. A.; Boddu, Sai H. S.; Amawi, Sadam; Obeid, Mohammad A.; Ashby, Charles R.; Tiwari, Amit K.

doi:10.1007/s00280-020-04211-z

Cited by 9 publications

(5 citation statements)

References 96 publications

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“…To investigate the role of ALDH1A1 and ALDH1A3 for tumor cell survival in the blood stream and during the extravasation process in vivo, we implemented the Zebrafish (Danio rerio) model to xenograft with human prostate cells. Zebrafish represent a powerful tool for cancer research: human and zebrafish genomes share gene orthology for 82% of disease-causing genes (Amawi et al, 2021;Howe et al, 2013;Letrado et al, 2018;Terriente and Pujades, 2013), and transparent embryos can be injected with cancer cells at various locations, allowing the live observation of tumor cells (Dietrich et al, 2021). In our study, we have used the embryonic and larval in vivo model to analyze the role of ALDH1A1 and ALDH1A3 genes in human cancer dissemination.…”

Section: Aldh Genes Differentially Regulate Prostate Cancer Metastasismentioning

confidence: 99%

The distinct role of ALDH1A1 and ALDH1A3 in the regulation of prostate cancer metastases

Gorodetska

Offermann

Pueschel

et al. 2021

Preprint

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Cancer stem cells (CSC) are characterized by high self-renewal capacity, tumor-initiating potential, and therapy resistance. Aldehyde dehydrogenase (ALDH)+ cell population serves as an indicator of prostate CSCs with increased therapy resistance, enhanced DNA double-strand break repair, and activated epithelial-mesenchymal transition (EMT) and migration. Numerous ALDH genes contribute to ALDH enzymatic activity; however, only some of them showed clinical relevance. We found that ALDH1A1 and ALDH1A3 genes functionally regulate CSC properties and radiation sensitivity of PCa. We revealed a negative correlation between ALDH1A1 and ALDH1A3 expression in publicly available prostate cancer (PCa) datasets and demonstrated that ALDH1A1 and ALDH1A3 have opposing predictive value for biochemical recurrence-free survival. Our data suggest an association of ALDH1A1 with the metastatic burden, elucidating the role of ALDH genes in the metastatic spread and homing to the bone, which can be, at least partially, attributed to regulating the transforming growth factor beta 1 (TGFB1) and matrix metalloproteinases (MMPs). ALDH genes play a diverse role in PCa development under AR and β-catenin-dependent regulation, with ALDH1A1 becoming dominant in later stages of tumor development when PCa cells gain androgen independence. Taken together, our results indicate that ALDH1A1 and ALDH1A3 modulate PCa radiosensitivity, regulate CSCs phenotype, and spread of PCa cells to the bone, therefore having clinical implication for identifying patients at high risk for progression to metastatic disease.

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Section: Aldh Genes Differentially Regulate Prostate Cancer Metastasismentioning

confidence: 99%

The distinct role of ALDH1A1 and ALDH1A3 in the regulation of prostate cancer metastases

Gorodetska

Offermann

Pueschel

et al. 2021

Preprint

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“…Furthermore, the efficacy of most vaccines requires enhancement by the use of adjuvants, agents which can increase immune responses; some of which can be used as vaccine delivery systems to allow mucosal immunisation [15,16]. Particulate based systems, such as liposomes, NISV and bilosomes, are of great interest as they can mimic the particulate nature of viruses.…”

Section: Introductionmentioning

confidence: 99%

Mucosal and systemic immune responses following mucosal immunisation of tetanus toxoid entrapped in lipid nanoparticles prepared by microwave reactor

Gebril¹,

Obeid²,

Bennett³

et al. 2022

European Journal of Pharmaceutics and Biopharmaceutics

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“…Gold, carbon and silica are the most commonly used types of NP; they are inorganic NPs. Advantageous features of NPs include low production cost, reproducibility and safety [ 35 ]. Polymeric NPs are a separate type of NP, and they have gained more attention recently because of their ease of preparation, biodegradability, biocompatibility and reduced cytotoxicity [ 36 ].…”

Section: Nanoparticles and Novel Covid-19 Mrna Vaccine Developmentmentioning

confidence: 99%

SARS-CoV-2: Vaccinology and Emerging therapeutics; Challenges and Future Developments

Adesokan¹,

Obeid

Lawal³

2022

Ther. Deliv.

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As SARS-CoV-2 emerge, variants such as Omicron (B.1.1.529), Delta (B.1.617.2), and those from the United Kingdom (B.1.1.7), South Africa (B.1.351), Brazil (P.1) and India (B.1.6.17 lineage) have raised concerns of the reduced neutralising ability of antibodies and increased ability to evade the current six approved COVID-19 vaccine candidates. This viewpoint advocates for countries to conduct prior efficacy studies before they embark on mass vaccination and addresses the role of nanoparticles as carrier vehicles for these vaccines with a view to explore the present challenges and forge a path for a stronger and more viable future for the development of vaccines for SARS-CoV-2 and future pandemics. We also look at the emerging prophylactics and therapeutics in the light of ongoing cases of severe and critical COVID-19.

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The use of zebrafish model in prostate cancer therapeutic development and discovery

Cited by 9 publications

References 96 publications

The distinct role of ALDH1A1 and ALDH1A3 in the regulation of prostate cancer metastases

The distinct role of ALDH1A1 and ALDH1A3 in the regulation of prostate cancer metastases

Mucosal and systemic immune responses following mucosal immunisation of tetanus toxoid entrapped in lipid nanoparticles prepared by microwave reactor

SARS-CoV-2: Vaccinology and Emerging therapeutics; Challenges and Future Developments

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