The usefulness of the retinal sensitivity measurement with a microperimetry for predicting the visual prognosis of branch retinal vein occlusion with macular edema

Abstract

Purpose To evaluate the usefulness of the retinal sensitivity in branch retinal vein occlusion (BVO) with macular edema (ME) following the anti-vascular endothelial growth factor (anti-VEGF) treatment. Methods Best-corrected visual acuity (BCVA), microperimetry, and optical coherence tomography (OCT) measurements were carried out in 20 patients with BVO with ME, at baseline and 1 month after the anti-VEGF treatment. The relationships among BCVA, mean retinal sensitivity (MS), macular volume (MV), central retinal thickness (CRT), integrity of ellipsoid zone (EZ), mean retinal sensitivity in the most affected quadrant (qMS), and macular volume in the most affected quadrant (qMV) were investigated. In addition, the relationships among the change in BCVA at 1 month (ΔBCVA1m), mean sensitivity in the most affected quadrant at 1 month (ΔqMS1m), MV in the most affected quadrant at 1 month (ΔqMV1m), and CRT at 1 month (ΔCRT1m) were analyzed. The optimal model for BCVA at 3 months after the treatment (BCVA3m) was identified. Results There was not a significant difference in BCVA (paired Wilcoxon test, p = 0.058) between at baseline and after the treatment, but there were significant differences in MS, MV, CRT, qMS, and qMV (p < 0.05). There was a significant relationship between ΔqMS1m and ΔMV1m, ΔCRT1m, and ΔqMV1m, respectively. ΔMS1m or ΔqMS1m and BCVA at baseline and ΔBCVA1m were selected as explanatory variables in the optimal model for BCVA3m. Conclusion Retinal sensitivity was related to retinal structure, whereas this was not the case with BCVA. In addition, retinal sensitivity was useful to predict BCVA after anti-VEGF therapy.

Comparison between blue-on-yellow and white-on-white perimetry in patients with branch retinal vein occlusion

“…In contrast, several previous studies have suggested the usefulness of measuring RS using W/W perimetry in eyes with BRVO. For instance, some studies have suggested the usefulness of this approach in detecting early and subtle functional damage in eyes with BRVO 5,[35][36][37] . In addition, clinically, it is often observed that patients with resolved BRVO describe visual symptoms such as decreased RS, metamorphopsia, and central scotoma that cannot be fully explained solely on the basis of BCVA.…”

Clinical Perspectives and Trends: Microperimetry as a Trial Endpoint in Retinal Disease

“…Notably, it is listed as a primary or secondary endpoint or keyword in over 150 clinical studies registered online with the US National Library of Medicine [17]. It has been used to help characterise a wide range of ocular conditions, including AMD [18], choroidal neovascularisation (CNV) [19], macular oedema arising from diabetes [20] or uveitis [21], central serous chorioretinopathy (CSCR) [22], retinal vein occlusion [23], birdshot chorioretinopathy [24], macular holes [25], epiretinal membranes [26], and IRD such as Stargardt disease [27], choroideremia [28-30], juvenile X-linked retinoschisis [31], and RPGR -associated X-linked retinitis pigmentosa [32]. To a lesser extent, MP has already been adopted as an endpoint in interventional retinal disease clinical trials.…”

Assessment of macular function in patients with non-vascularized pigment epithelial detachment

“…In previous studies, the assessment of visual function in patients with AMD has been predominantly conducted through visual acuity (VA) evaluation which mainly reflects the function at the fovea. Recent reports have suggested the benefit of measuring visual function in a wider macular area using microperimetry, such as MP-3 microperimetry (Nidek, Japan) 27 , 28 . In the current study, visual function assessment was carried out using VA and the MP-3 microperimetry.…”