The usefulness of18F-FDG PET images obtained 2 hours after intravenous injection in liver tumor

Koyama, Koichi; Okamura, Terue; Kawabe, Joji; Ozawa, Nozomi; Higashiyama, Shigeki; Ochi, Hironobu; Yamada, Ryusaku

doi:10.1007/bf02996297

Cited by 31 publications

(23 citation statements)

References 14 publications

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“…Nonetheless, liver metastases measuring Ͻ 1 cm in diameter have proven to be undetectable. 38,39 The additional value of PET as a noninvasive imaging modality for esophageal carcinoma has been investigated extensively in recent years. In the current study, PET was 14% more informative in the staging of esophageal carcinoma compared with CT. Flanagan et al 8 found that PET findings changed the management strategy significantly in 17% of all patients with esophageal carcinoma (6 of 36).…”

Section: Discussionmentioning

confidence: 99%

The incremental effect of positron emission tomography on diagnostic accuracy in the initial staging of esophageal carcinoma

Kato

Miyazaki

Nakajima

et al. 2004

Cancer

224

107

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BACKGROUNDThe purpose of the current study was to assess whether [18F]fluorodeoxyglucose positron emission tomography (FDG‐PET) provides incremental value (e.g., additional information on lymph node involvement or the presence of distant metastases) compared with computed tomography (CT) in patients with esophageal carcinoma.METHODSThe authors examined 149 consecutive patients with thoracic esophageal carcinoma. Eighty‐one patients underwent radical esophagectomy without pretreatment, 17 received chemoradiotherapy followed by surgery, 3 underwent endoscopic mucosal resection, and the remaining 48 patients received definitive radiotherapy and chemotherapy. The diagnostic accuracy of FDG‐PET and CT was evaluated at the time of diagnosis.RESULTSThe primary tumor was visualized using FDG‐PET in 119 (80%) of 149 patients. Regarding lymph node metastases, FDG‐PET had 32% sensitivity, 99% specificity, and 93% accuracy for individual lymph node group evaluation and 55% sensitivity, 90% specificity, and 72% accuracy for lymph node staging evaluation. PET exhibited incremental value over CT with regard to lymph node status in 14 of 98 patients who received surgery: 6 patients with negative CT findings were eventually shown to have lymph node metastases (i.e., they had positive PET findings and a positive reference standard [RS]); 6 patients with positive CT findings were shown not to have lymph node metastases (i.e., they had negative PET findings and a negative RS); and 2 patients were shown to have cervical lymph node metastases in addition to mediastinal or abdominal lymph node metastases. Among the remaining patients, PET showed incremental value over CT with regard to distant organ metastases in six patients. The overall incremental value of PET compared with CT with regard to staging accuracy was 14% (20 of 149 patients).CONCLUSIONSFDG‐PET provided incremental value over CT in the initial staging of esophageal carcinoma. At present, combined PET‐CT may be the most effective method available for the preoperative staging of esophageal tumors. Cancer 2005. © 2004 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

The incremental effect of positron emission tomography on diagnostic accuracy in the initial staging of esophageal carcinoma

Kato

Miyazaki

Nakajima

et al. 2004

Cancer

224

107

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“…The differences in the accumulation of FDG in metastatic liver tumors and HCC could be explained by the differences of the activity of enzymes involved in glucose metabolism. The activity of glucose-6-phosphatase (G-6-Pase), which converts FDG-6-P to FDG, is reported to be high in normal liver and nearly zero in metastatic liver tumors [53]. Thus, FDG decreases in normal liver tissue and increases in metastatic liver tumors with time after the administration of FDG.…”

Section: Distant Metastasismentioning

confidence: 97%

“…As a result, metastatic tumor lesions are clearly delineated as distinct positive lesions in the liver. Koyama et al [53] compared FDG-PET images of liver tumors obtained 2 h after FDG intravenous injection with those obtained 1 h after injection. The former images enabled clear visualization of liver tumors, especially metastatic lesions.…”

Section: Distant Metastasismentioning

confidence: 99%

Positron emission tomography in esophageal cancer

et al. 2005

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Positron emission tomography (PET), a functional imaging modality, has provided the transition between the research environment and the clinical environment over the last 10 years. Its primary use is in the field of oncology, where it is being increasingly used in the management of several tumor types including esophageal cancer. 18 F-Fluorodeoxyglucose PET (FDG-PET) scans may also be used to distinguish between benign and malignant tumors, to identify different stages of tumor spread, to assess for tumor recurrence, and monitor the response to therapy of malignant diseases. This review aims to outline the current and future roles of PET scanning in the field of esophageal cancer.

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“…Recently, there have been several attempts to enhance the detection rate of malignant lesions with dual-time-point FDG PET scans [13][14][15][16][17][18][19][20][21][22][23][24]. According to previous studies, tumor tissue shows gradual accumulation of FDG, suggesting that the contrast between tumor and normal background tissue on delayed PET imaging could be higher than that on routine PET imaging [13,14,25].…”

Section: Introductionmentioning

confidence: 99%

Detection of Hepatic Metastases Using Dual-Time-Point FDG PET/CT Scans in Patients with Colorectal Cancer

et al. 2010

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The usefulness of18F-FDG PET images obtained 2 hours after intravenous injection in liver tumor

Abstract: FDG PET studies performed 2 hours after intravenous injection were useful for clear visualization of liver tumors, especially metastatic liver tumors.

Cited by 31 publications

References 14 publications

The incremental effect of positron emission tomography on diagnostic accuracy in the initial staging of esophageal carcinoma

The incremental effect of positron emission tomography on diagnostic accuracy in the initial staging of esophageal carcinoma

Positron emission tomography in esophageal cancer

Detection of Hepatic Metastases Using Dual-Time-Point FDG PET/CT Scans in Patients with Colorectal Cancer

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