The Uses of 2-Amino-4-Phenylthiazole in the Synthesis of Coumarin, Pyran, Pyridine and Thiazole Derivatives with Antitumor Activities

Hamed, Faten I.; Mohamed, Abeer A.

doi:10.4236/oalib.1103526

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Condensation of 13 with three types of substituted benzaldehydes (namely, benzaldehyde 4-chlorobenzaldehyde or 4-methoxybenzaldehyde) produced the corresponding benzylidene derivatives 14 . In addition, when compound 13 reacted with salicylaldehyde, it gave the coumarin derivative 15 ( Scheme 3 ) [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

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An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities

2021

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Amongst sulfur- and nitrogen-containing heterocyclic compounds, the 2-aminothiazole scaffold is one of the characteristic structures in drug development as this essential revelation has several biological activities abiding it to act as an anticancer, antioxidant, antimicrobial and anti-inflammatory agent, among other things. Additionally, various 2-aminothiazole-based derivatives as medical drugs have been broadly used to remedy different kinds of diseases with high therapeutic influence, which has led to their wide innovations. Owing to their wide scale of biological activities, their structural variations have produced attention amongst medicinal chemists. The present review highlights the recently synthesized 2-aminothiazole-containing compounds in the last thirteen years (2008–2020). The originality of this proposal is based on the synthetic strategies developed to access the novel 2-aminothiazole derivatives (N-substituted, 3-substituted, 4-substituted, multi-substituted, aryl/alkyl substituents or acyl/other substituents). The literature reports many synthetic pathways of these 2-aminothiazoles associated with four different biological activities (anticancer, antioxidant, antimicrobial and anti-inflammatory activities). It is wished that this review will be accommodating for new views in the expedition for rationalistic designs of 2-aminothiazole-based medical synthetic pathways.

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Section: Resultsmentioning

confidence: 99%

“…Furthermore, the multi-component reaction of 13 with substituted benzaldehydes and thiourea produced the pyrimidine scaffolds 20 . 2-Amino-4-(4-chlorophenyl)-6-(4-phenylthiazol-2-yl)-4 H -pyran-3,5-dicarbonitrile ( 17 , X = Cl) indicated the maximum cytotoxicity among the synthesized compounds towards six cancer cell lines [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities

2021

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“…Also, they prepared N-phenylthiourea, N-cyanoacetyl, arylidene, aryl hydrazone, and pyrimidine derivatives, but were exhibited moderate activity (Fig. 10) [75].…”

Section: Modification Of 2-amine To 2-alkylaminomentioning

confidence: 99%

Development and therapeutic potential of 2-aminothiazole derivatives in anticancer drug discovery

Alizadeh

Hashemi

2021

Med Chem Res

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Currently, the development of anticancer drug resistance is significantly restricted the clinical efficacy of the most commonly prescribed anticancer drug. Malignant disease is widely prevalent and considered to be the major challenges of this century, which concerns the medical community all over the world. Consequently, investigating small molecule antitumor agents, which could decrease drug resistance and reduce unpleasant side effect is more desirable. 2-aminothiazole scaffold has emerged as a promising scaffold in medicinal chemistry and drug discovery research. This nucleus is a fundamental part of some clinically applied anticancer drugs such as dasatinib and alpelisib. Literature survey documented that different 2aminothiazole analogs exhibited their potent and selective nanomolar inhibitory activity against a wide range of human cancerous cell lines such as breast, leukemia, lung, colon, CNS, melanoma, ovarian, renal, and prostate. In this paper, we have reviewed the progresses and structural modification of 2-aminothiazole to pursuit potent anticancers and also highlighted in vitro activities and in silico studies. The information will useful for future innovation.

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Synthesis of 3-Alkyl-5-(diethylaminomethyl)-1-(1,3-thiazol-4-yl)-1H-pyrazoles

Karayeva,

Shatirova,

Mamedov

et al. 2024

Russ J Org Chem

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The Uses of 2-Amino-4-Phenylthiazole in the Synthesis of Coumarin, Pyran, Pyridine and Thiazole Derivatives with Antitumor Activities

Cited by 4 publications

References 13 publications

An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities

An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities

Development and therapeutic potential of 2-aminothiazole derivatives in anticancer drug discovery

Synthesis of 3-Alkyl-5-(diethylaminomethyl)-1-(1,3-thiazol-4-yl)-1H-pyrazoles

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