The Utility of Novel Fish-Skin Derived Acellular Dermal Matrix (Kerecis) as a Wound Dressing Material

Kim, Tae Hyung; Park, Jun Ho; Jeong, Hyun Gyo; Wee, Syeo Young

doi:10.22467/jwmr.2020.01228

Cited by 14 publications

(18 citation statements)

References 15 publications

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“…Recent studies using acellular fish skin grafts demonstrate faster and more efficacious wound healing than traditional wound dressings, bovine collagen grafts, or dehydrated human amnion/chorion membrane allograft. 19 - 22 …”

Section: Discussionmentioning

confidence: 99%

New Medical Device and Therapeutic Approvals in Otolaryngology: State of the Art Review of 2021

et al. 2022

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Objective To evaluate new medical devices and drugs pertinent to otolaryngology–head and neck surgery that were approved by the Food and Drug Administration (FDA) in 2021. Data Sources Publicly available FDA device and drug approvals from ENT (ear, nose, and throat), anesthesia, neurosurgery, plastic surgery, and general surgery FDA committees. Review Methods FDA device and therapeutic approvals were identified and reviewed by members of the American Academy of Otolaryngology–Head and Neck Surgery’s Medical Devices and Drugs Committee. Two independent reviewers assessed the relevance of devices and drugs to otolaryngologists. Medical devices and drugs were then allocated to their respective subspecialty fields for critical review based on available scientific literature. Conclusions The Medical Devices and Drugs Committee reviewed 1153 devices and 52 novel drugs that received FDA approval in 2021 (67 ENT, 106 anesthesia, 618 general surgery and plastic surgery, 362 neurosurgery). Twenty-three devices and 1 therapeutic agent relevant to otolaryngology were included in the state of the art review. Advances spanned all subspecialties, including over-the-counter hearing aid options in otology, expanding treatment options for rhinitis in rhinology, innovative laser-safe endotracheal tubes in laryngology, novel facial rejuvenation and implant technology in facial plastic surgery, and advances in noninvasive and surgical treatment options for obstructive sleep apnea. Implications for Practice FDA approvals for new technology and pharmaceuticals present new opportunities across subspecialties in otolaryngology. Clinicians’ nuanced understanding of the safety, advantages, and limitations of these innovations ensures ongoing progress in patient care.

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Section: Discussionmentioning

confidence: 99%

New Medical Device and Therapeutic Approvals in Otolaryngology: State of the Art Review of 2021

et al. 2022

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“…An alternative to the use of commercial Atlantic cod acellular skin grafts is the use of tilapia, that can be in-house processed following previously described guidelines. 110,[129][130][131][132] Adjunctive mechanical therapies A variety of adjunctive mechanical techniques have been reported to enhance wound healing over the last few decades. Examples of these include negative pressure wound therapy, oxygen therapies (e.g.…”

Section: Skin Substitutesmentioning

confidence: 99%

“…A detailed description on the processing and use of acellular fish skin grafts can be found elsewhere; use in veterinary is anecdotal and no publications are available. An alternative to the use of commercial Atlantic cod acellular skin grafts is the use of tilapia, that can be in‐house processed following previously described guidelines 110,129–132 …”

Section: Bioactive Wound Dressings and Technologiesmentioning

confidence: 99%

Local wound management: A review of modern techniques and products

Aisa

Parlier

2022

Veterinary Dermatology

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Management of wounds is a commonly performed and essential aspect of small animal veterinary medicine. Appropriate wound management is a difficult art to master, due to the inherent complexity of the clinical scenario, as well as the ever-evolving nature of the field with the constant addition of new products and techniques. This article reviews key concepts that may help the practitioner better understand the natural process of wound healing, factors that delay healing and strategies to help improve the local wound environment to make it more conducive to healing during open wound management. The concept of wound bed preparation is defined before common local wound management strategies, such as wound lavage and debridement, are discussed in more detail. Key aspects of the management of biofilms and appropriate use of antimicrobial agents are also reviewed. Finally, the concept of moist wound healing and its impact in modern wound management is explained before a broad variety of types of wound dressings are reviewed, with a particular focus on active dressings.

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“…Comparing with ADM derived from human skin, animal ADM products are more cost-effective and more frequently applied for large skin defects [21]. Some animal ADM, such as those from bovine, porcine, and fish skin, have been approved by the US Food and Drug Administration [39][40][41]. For instance, Kerecis™ graft, a newly-approved ADM product from fish skin, is very attractive for wound management because of the anti-inflammatory property of its exclusive omega-3 polyunsaturated fatty acids [42].…”

Section: Acellular Dermal Matrix (Adm)mentioning

confidence: 99%

“…Further, the Kerecis™ graft avoids the risk of potential viral and prion transmission, which might be seen in mammalian-derived products [34]. According to recent clinical studies, the Kerecis™ graft can heal acute or chronic deep skin wounds with a shorter healing time than conventional wound treatment [41,42].…”

Section: Acellular Dermal Matrix (Adm)mentioning

confidence: 99%

Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing

Huang

Xie

et al. 2021

Pharmaceutics

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Membranous extracellular matrix (ECM)-based scaffolds are one of the most promising biomaterials for skin wound healing, some of which, such as acellular dermal matrix, small intestinal submucosa, and amniotic membrane, have been clinically applied to treat chronic wounds with acceptable outcomes. Nevertheless, the wide clinical applications are always hindered by the poor mechanical properties, the uncontrollable degradation, and other factors after implantation. To highlight the feasible strategies to overcome the limitations, in this review, we first outline the current clinical use of traditional membranous ECM scaffolds for skin wound healing and briefly introduce the possible repair mechanisms; then, we discuss their potential limitations and further summarize recent advances in the scaffold modification and fabrication technologies that have been applied to engineer new ECM-based membranes. With the development of scaffold modification approaches, nanotechnology and material manufacturing techniques, various types of advanced ECM-based membranes have been reported in the literature. Importantly, they possess much better properties for skin wound healing, and would become promising candidates for future clinical translation.

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The Utility of Novel Fish-Skin Derived Acellular Dermal Matrix (Kerecis) as a Wound Dressing Material

Cited by 14 publications

References 15 publications

New Medical Device and Therapeutic Approvals in Otolaryngology: State of the Art Review of 2021

New Medical Device and Therapeutic Approvals in Otolaryngology: State of the Art Review of 2021

Local wound management: A review of modern techniques and products

Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing

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