The utilization of LTCC-PDMS bonding technology for microfluidic system applications – a simple fluorescent sensor

Malecha, Karol

doi:10.1108/mi-03-2016-0027

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…Besides, many examples of the three-dimensional stru placed inside the LTCC structure can be found in the literature, i.e., microchanne crochambers, micromixers, etc. [31][32][33]. In opposite to various polymer-based mic idic-microwave structures, due to the multilayer character of the mentioned techn the LTCC allows the fabrication of monolithic microfluidic-microwave devices [34 thermore-the unit cost of manufacturing the LTCC device is much lower in comp to the technology based on the glass/silicon substrates.…”

Section: Figurementioning

confidence: 99%

A Stripline-Based Integrated Microfluidic-Microwave Module

et al. 2021

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The paper presents the preliminary results on the development of an integrated stripline-based microwave-microfluidic module. The measurements were performed in a frequency range from 300 MHz up to 12 GHz, with the microchannel filled with three different test fluids—deionized water, the ethanol-water solution and pure ethanol. Due to the higher-than-expected losses in transmittance, the selected module was examined with use of the cross-sections taken along its length. The possible causes were highlighted and described. Likewise, the proposed areas of further investigations have been clearly described.

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Section: Figurementioning

confidence: 99%

A Stripline-Based Integrated Microfluidic-Microwave Module

et al. 2021

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“…It was also long-lasting, whereby it did not disintegrate over a control period of three years, and it kept its original optical properties. Another example is a microfluidic sensor [13], which allowed for fluorescence measurements in a ceramic microsystem. The earlier-described LTCC/PDMS manufacturing method is, therefore, very promising for biosensing.…”

Section: Modification Proceduresmentioning

confidence: 99%

Biomaterial Embedding Process for Ceramic–Polymer Microfluidic Sensors

Nawrot

Malecha

2020

Sensors

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One of the major issues in microfluidic biosensors is biolayer deposition. Typical manufacturing processes, such as firing of ceramics and anodic bonding of silicon and glass, involve exposure to high temperatures, which any biomaterial is very vulnerable to. Therefore, current methods are based on deposition from liquid, for example, chemical bath deposition (CBD) and electrodeposition (ED). However, such approaches are not suitable for many biomaterials. This problem was partially resolved by introduction of ceramic–polymer bonding using plasma treatment. This method introduces an approximately 15-min-long window for biomodification between plasma activation and sealing the system with a polymer cap. Unfortunately, some biochemical processes are rather slow, and this time is not sufficient for the proper attachment of a biomaterial to the surface. Therefore, a novel method, based on plasma activation after biomodification, is introduced. Crucially, the discharge occurs selectively; otherwise, it would etch the biomaterial. Difficulties in manufacturing ceramic biosensors could be overcome by selective surface modification using plasma treatment and bonding to polymer. The area of plasma modification was investigated through contact-angle measurements and Fourier-transform infrared (FTIR) analyses. A sample structure was manufactured in order to prove the concept. The results show that the method is viable.

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“…An entirely new approach has been shown by Malecha by introduction of LTCC bonding with PDMS [ 119 ], which—as mentioned earlier—is a very popular microfluidic material. Then, an optical sensor for absorbance measurement has been developed using this technique [ 120 ]. The latest method is still in development.…”

Section: Technology Of Microfluidic Systems With Fluorescence Detementioning

confidence: 99%

A Fluorescent Biosensors for Detection Vital Body Fluids’ Agents

Nawrot

Drzozga

Baluta

et al. 2018

Sensors

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The clinical applications of sensing tools (i.e., biosensors) for the monitoring of physiologically important analytes are very common. Nowadays, the biosensors are being increasingly used to detect physiologically important analytes in real biological samples (i.e., blood, plasma, urine, and saliva). This review focuses on biosensors that can be applied to continuous, time-resolved measurements with fluorescence. The material presents the fluorescent biosensors for the detection of neurotransmitters, hormones, and other human metabolites as glucose, lactate or uric acid. The construction of microfluidic devices based on fluorescence uses a variety of materials, fluorescent dyes, types of detectors, excitation sources, optical filters, and geometrical systems. Due to their small size, these devices can perform a full analysis. Microfluidics-based technologies have shown promising applications in several of the main laboratory techniques, including blood chemistries, immunoassays, nucleic-acid amplification tests. Of the all technologies that are used to manufacture microfluidic systems, the LTCC technique seems to be an interesting alternative. It allows easy integration of electronic and microfluidic components on a single ceramic substrate. Moreover, the LTCC material is biologically and chemically inert, and is resistant to high temperature and pressure. The combination of all these features makes the LTCC technology particularly useful for implementation of fluorescence-based detection in the ceramic microfluidic systems.

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The utilization of LTCC-PDMS bonding technology for microfluidic system applications – a simple fluorescent sensor

Abstract: Article information:To cite this document: Karol Malecha , (2016),"The utilization of LTCC-PDMS bonding technology for microfluidic system applications -a simple fluorescent

Cited by 7 publications

References 25 publications

A Stripline-Based Integrated Microfluidic-Microwave Module

A Stripline-Based Integrated Microfluidic-Microwave Module

Biomaterial Embedding Process for Ceramic–Polymer Microfluidic Sensors

A Fluorescent Biosensors for Detection Vital Body Fluids’ Agents

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