The Vaginal Fungi

Carter, Bayard; Jones, Claudius P.; Creadick, Robert N.; Parker, Roy T.; Turner, Violet

doi:10.1111/j.1749-6632.1960.tb40900.x

Cited by 17 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First studies on the fungal community in women's reproductive tract date back to 1929 (Carter et al, 1959, p. 195). The vaginal bacteriome is dominated by Lactobacillus species (Human Microbiome Project Consortium, 2012b; K. Li et al, 2012), and the low‐pH environment caused by their lactic acid production inhibits the growth of most of the filamentous species, resulting in a selective fungal community (Underhill & Iliev, 2014).…”

Section: The Human Mycobiota: Richness and Diversity In The Human Bod...mentioning

confidence: 99%

Ascomycetes yeasts: The hidden part of human microbiome

Nenciarini,

Renzi,

di Paola

et al. 2024

WIREs Mechanisms of Disease

View full text Add to dashboard Cite

The fungal component of the microbiota, the mycobiota, has been neglected for a long time due to its poor richness compared to bacteria. Limitations in fungal detection and taxonomic identification arise from using metagenomic approaches, often borrowed from bacteriome analyses. However, the relatively recent discoveries of the ability of fungi to modulate the host immune response and their involvement in human diseases have made mycobiota a fundamental component of the microbial communities inhabiting the human host, deserving some consideration in host–microbe interaction studies and in metagenomics. Here, we reviewed recent data on the identification of yeasts of the Ascomycota phylum across human body districts, focusing on the most representative genera, that is, Saccharomyces and Candida. Then, we explored the key factors involved in shaping the human mycobiota across the lifespan, ranging from host genetics to environment, diet, and lifestyle habits. Finally, we discussed the strengths and weaknesses of culture‐dependent and independent methods for mycobiota characterization. Overall, there is still room for some improvements, especially regarding fungal‐specific methodological approaches and bioinformatics challenges, which are still critical steps in mycobiota analysis, and to advance our knowledge on the role of the gut mycobiota in human health and disease.This article is categorized under: Immune System Diseases > Genetics/Genomics/Epigenetics Immune System Diseases > Environmental Factors Infectious Diseases > Environmental Factors

show abstract

Section: The Human Mycobiota: Richness and Diversity In The Human Bod...mentioning

confidence: 99%

Ascomycetes yeasts: The hidden part of human microbiome

Nenciarini,

Renzi,

di Paola

et al. 2024

WIREs Mechanisms of Disease

View full text Add to dashboard Cite

show abstract

“…Fungi are important members of the vaginal ecosystem in healthy women and the vaginal mycobiome was first described by Castellani in 1929 [ 8 , 143 ]. Candida albicans , an opportunistic fungal pathogen, colonizes 20% of women without causing any overt symptoms, yet is one of the leading causes of infectious vaginitis.…”

Section: Genitourinary Tract Mycobiomementioning

confidence: 99%

“…The vaginal mycobiome consists primarily of yeast-like microorganisms originating from Ascomycota and Basidiomycota [ 8 , 143 ]. The research of the team Guo et al (2012) [ 146 ] mentions peronosporomycota (oomycota) as well, but these have not been reported in other studies so far.…”

Section: Genitourinary Tract Mycobiomementioning

confidence: 99%

The Human Mycobiome: Colonization, Composition and the Role in Health and Disease

Belvončíková

Šplíchalová

Vídeňská

et al. 2022

JoF

View full text Add to dashboard Cite

The mycobiome is the fungal component of the human microbial ecosystem that represents only a small part of this environment but plays an essential role in maintaining homeostasis. Colonization by fungi begins immediately after birth. The initial mycobiome is influenced by the gestational age of a newborn, birth weight, delivery method and feeding method. During a human’s life, the composition of the mycobiome is further influenced by a large number of endogenous and exogenous factors. The most important factors are diet, body weight, age, sex and antibiotic and antifungal therapy. The human mycobiome inhabits the oral cavity, gastrointestinal tract, respiratory tract, urogenital tract and skin. Its composition can influence the gut–brain axis through immune and non-immune mediated crosstalk systems. It also interacts with other commensals of the ecosystem through synergistic and antagonistic relationships. Moreover, colonization of the gut by opportunistic fungal pathogens in immunocompromised individuals can lead to clinically relevant disease states. Thus, the mycobiome represents an essential part of the microbiome associated with a variety of physiological and pathological processes. This review summarizes the current knowledge on the composition of the mycobiome in specific sites of the human body and its role in health and disease.

show abstract

“…In contrast, the mycelial or hyphal form contributes mostly to mucosal invasion and adherence [3], which are characteristics of disease with symptoms. Candida infections can be present in various parts of the body, and usually develop on mucous membranes such as the mouth or genitals, but the bloodstream can also be affected [4,5]. Invasive candidiasis (IC) is a serious infection caused by different species of candida that can affect the blood, heart, brain, eyes, bones, and other parts of the body.…”

Section: Introductionmentioning

confidence: 99%

Detection of Candida albicans Using a Manufactured Electrochemical Sensor

Dutta

Hsieh

et al. 2021

Micromachines

View full text Add to dashboard Cite

Candida albicans is a commensal fungus that is responsible for a lot of nosocomial infections in immunocompromised people. Cell culture is currently the predominant method for diagnosing candidiasis, but it is time consuming. In this study, we developed a rapid screen procedure by devising a method for detecting C. albicans with the use of electrochemical sensors. Through this experiment, we propose a method for the detection of C. albicans in the system through the use of personal glucose meters. The hemicellulase was used to break down the cell wall of C. albicans to glucose and oligo, which can be detected by a glucose meter. The spiked samples were prepared suspending C. albicans in urine and serum, demonstrating the feasibility of the developed method in a real situation.

show abstract

The Vaginal Fungi

Cited by 17 publications

References 28 publications

Ascomycetes yeasts: The hidden part of human microbiome

Ascomycetes yeasts: The hidden part of human microbiome

The Human Mycobiome: Colonization, Composition and the Role in Health and Disease

Detection of Candida albicans Using a Manufactured Electrochemical Sensor

Contact Info

Product

Resources

About