The Validity of Current Concepts of Hypothalamo-Neurohypo-physeal Neurosecretion

Jc, Sloper

doi:10.1016/s0079-6123(08)64271-5

Cited by 5 publications

(3 citation statements)

References 49 publications

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“…Despite being less common than chemical synapses, gap junctions are ubiquitous in the central nervous system. Example includes the inferior olivary nucleus [ 71 – 73 ], the thalamic reticular nucleus [ 74 , 75 ], the hippocampus [ 36 , 76 ], the retina [ 52 , 77 ], the olfactory bulb [ 78 ], the locus coeruleus [ 79 ], or also the neocortex [ 80 , 81 ]. Moreover, they drastically alter the firing activity of their connecting neurons [ 82 , 83 ], as well as the network dynamics [ 20 – 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Llinas et al (1974); Benardo and Foster(1986)), the thalamic reticular nucleus(Landisman et al (2002); Long et al(2004)), the hippocampus(Jefferys (1995); Hormuzdi et al(2001)), the retina (Vaney and Taylor(2002); Jin and Ribelayga (2016)), the olfactory bulb (Zhang and Sulzer(2003)), the locus coeruleus(Christie et al (1989)), or also the neocortex(Sloper (1972); Sloper and Powell(1978)). Moreover, they drastically alter the firing activity of their connecting neurons(Haas (2015); van Welie et al (2016)), as well as the network dynamics (Traub et al (2001); Pfeuty et al (2003); Kopell and Ermentrout (2004); Connors and Long (2004); Tchumatchenko and Clopath (2014)).…”

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confidence: 99%

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Gap junction plasticity as a mechanism to regulate network-wide oscillations

2018

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Cortical oscillations are thought to be involved in many cognitive functions and processes. Several mechanisms have been proposed to regulate oscillations. One prominent but understudied mechanism is gap junction coupling. Gap junctions are ubiquitous in cortex between GABAergic interneurons. Moreover, recent experiments indicate their strength can be modified in an activity-dependent manner, similar to chemical synapses. We hypothesized that activity-dependent gap junction plasticity acts as a mechanism to regulate oscillations in the cortex. We developed a computational model of gap junction plasticity in a recurrent cortical network based on recent experimental findings. We showed that gap junction plasticity can serve as a homeostatic mechanism for oscillations by maintaining a tight balance between two network states: asynchronous irregular activity and synchronized oscillations. This homeostatic mechanism allows for robust communication between neuronal assemblies through two different mechanisms: transient oscillations and frequency modulation. This implies a direct functional role for gap junction plasticity in information transmission in cortex.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Gap junction plasticity as a mechanism to regulate network-wide oscillations

2018

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“…Evidence for the concept of neurosecretion in the HNS has in the past depended upon the use of cytochemical reagents which interact with intraneuronal inclusions rich in disulphide bonds (for reviews see References [63][64][65][66][67][68]. It can now be demonstrated by immunohistological techniques that protein (neurophysin) extracted from the mammalian posterior pituitary gland is also present in the neurosecretory neurons of the hypothalamus and infundibulum.…”

Section: Discussionmentioning

confidence: 88%