The validity of the criteria for primary infection of Chlamydophila pneumoniae in children by measuring ELISA IgM antibodies

Kamata, Ayako; Obinata, Kaoru; Niizuma, Takahiro; Kinoshita, Keiji; Shimizu, Toshiaki

doi:10.1007/s10156-011-0327-x

Cited by 4 publications

(4 citation statements)

References 20 publications

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“…Furthermore, it may be that the pharyngeal swabs special for virus preservation decreased the MP/ CP detection rate compared with sputum samples used in other studies, and the single sampling may also decreased detection rate. Some other studies reported that children younger than 3 years, which are the majority in our study, are rarely infected by MP or CP (Almasri et al, 2011, Kamata et al, 2011.…”

Section: Discussionsupporting

confidence: 46%

A new factor influencing pathogen detection by molecular assay in children with both mild and severe hand, foot, and mouth disease

Zhu

Zhao

Yao

et al. 2013

Diagnostic Microbiology and Infectious Disease

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This study aimed to find novel information concerning pathogen detection and some probable coinfection factors in hand, foot, and mouth disease (HFMD). In this study, 1104 clinically diagnosed HFMD patients were included. Enterovirus 71 (EV71), coxsackievirus A16 (CA16), and 14 different respiratory pathogens were examined from nasopharyngeal swabs using polymerase chain reaction (PCR) or reverse transcriptase PCR (RT-PCR). To evaluate the immune activation in HFMD patients, 8 cytokines and IgM antibodies to EV71 and CA16 from mild and severe patients were detected. Our results indicated that the severity of HFMD may affect the pathogen detection. The lower positive rates of enterovirus and respiratory viruses in severe HFMD cases by RT-PCR were probably related to stronger immune response. Therefore, immunological tests such as ELISA are essential supplements to PCR or RT-PCR in order to increase pathogen diagnosis in HFMD, especially in severe cases.

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Section: Discussionsupporting

confidence: 46%

A new factor influencing pathogen detection by molecular assay in children with both mild and severe hand, foot, and mouth disease

Zhu

Zhao

Yao

et al. 2013

Diagnostic Microbiology and Infectious Disease

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“…Although the cases focus on virology due to the nature (4,5), Toxoplasma gondii (6)(7)(8), the Coccidioides spp. causing coccidiomycosis (9), and Borrelia burgdorferi (10).…”

mentioning

confidence: 99%

Immunoglobulin M for Acute Infection: True or False?

Landry

2016

Clin Vaccine Immunol

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Immunoglobulin M (IgM) tests have clear clinical utility but also suffer disproportionately from false-positive results, which in turn can lead to misdiagnoses, inappropriate therapy, and premature closure of a diagnostic workup. Despite numerous reports in the literature, many clinicians and laboratorians remain unaware of this issue. In this brief review, a series of virology case examples is presented. However, a false-positive IgM can occur with any pathogen. Thus, when an accurate diagnosis is essential for therapy, prognosis, infection control, or public health, when the patient is sick enough to be hospitalized, or when the clinical or epidemiologic findings do not fit, IgM detection should not be accepted as a stand-alone test. Rather, whenever possible, the diagnosis should be confirmed by other means, including testing of serial samples and the application of additional test methods.

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“…To diagnose Cp infection effectively, we employed the HITAZYME-ELISA method with the generally accepted cut-off value for ELISA Cp IgM titers of over 2.00. 9 …”

Section: Discussionmentioning

confidence: 99%

“…A Cp infection was diagnosed when the anti-Cp IgM titers exceeded 2.00, regardless of the anti-Cp IgA or IgG titers. 9 …”

Section: Introductionmentioning

confidence: 99%

Chlamydia Pneumoniae Infection-Associated Erythema Multiforme

Imashuku

Kudo

2013

Pediatric Reports

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There is a well-known correlation between Herpes simplex (HSV) infection and erythema multiforme (EM). More recently, in Japan, it was found that Chlamydia pneumoniae (Cp) may promote the development of EM. All cases of Cp infection-associated EM that had been diagnosed in our clinic over the past two years (from 2011 to 2012) were analyzed. Cp infection was diagnosed on the basis of a significant increase (>2.00) in anti-Cp IgM titers, as measured by the HITAZYME-ELISA test. There were 7 cases of Cp-EM, one male and 6 females. Median age was 13 years (range 3-29 years). It is recommended that the possible involvement of Cp infection, besides HSV or Mycoplasma pneumoniae infections, should be considered in all cases of EM.

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The validity of the criteria for primary infection of Chlamydophila pneumoniae in children by measuring ELISA IgM antibodies

Cited by 4 publications

References 20 publications

A new factor influencing pathogen detection by molecular assay in children with both mild and severe hand, foot, and mouth disease

A new factor influencing pathogen detection by molecular assay in children with both mild and severe hand, foot, and mouth disease

Immunoglobulin M for Acute Infection: True or False?

Chlamydia Pneumoniae Infection-Associated Erythema Multiforme

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