The value of 18F-FDG PET/CT in the assessment of active idiopathic retroperitoneal fibrosis

Moroni, Gabriella; Castellani, Massimo; Balzani, Aurora; Dore, Roberto; Bonelli, Nicola; Longhi, Selena; Martinelli, Ida; Messa, Piergiorgio; Gerundini, Paolo

doi:10.1007/s00259-012-2144-6

Cited by 42 publications

(24 citation statements)

References 19 publications

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“…23 Adding information such as scores of contrast enhancement on CECT, as part of a hybrid 18 F-FDG-PET/CT examination, to 18 F-FDG uptake has been show to increase accuracy (93.9%) for discrimination between active and inactive disease. 24 In patients with IAA, positive 18 F-FDG uptake in the aneurysmal wall is regarded as helpful for monitoring progression as well as a predictive tool for evaluating rupture risk. 25 With the advance of new immunosuppressive drugs such as anti-IL-6, which rapidly normalize serological parameters and disease activity, it is difficult to follow-up so that diagnosis and response monitoring of A/CP might be challenging.…”

Section: Discussionmentioning

confidence: 99%

Perfusion-based assessment of disease activity in untreated and treated patients with aortitis and chronic periaortitis: correlation with CT morphological, clinical and serological data

Bier¹,

Henes²,

Eulenbruch³

et al. 2015

BJR

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Objective: To evaluate the role of perfusion-based assessment of inflammatory activity in patients with treated and untreated aortitis and chronic periaortitis as compared with clinical and serological markers. Methods: 35 patients (20 females; median age 66 years) with (peri) aortitis were retrospectively evaluated. All patients had clinical symptoms prompting at the time of imaging. All patients first underwent whole-body contrastenhanced CT and subsequently segmental volume perfusion CT for assessment of the degree of vascularization of (peri) aortitis as a surrogate marker for inflammatory activity. Blood flow, blood volume, volume transfer constant (k-trans), time to peak and mean transit time were determined. The thickness of the increased connective tissue formation was measured. Perfusion data were correlated with clinical symptoms and acute-phase inflammatory parameters such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and leukocyte number.Results: 21 of 35 patients were untreated and 14 of 35 had previous/ongoing immunosuppression. The interobserver agreement was good (k 5 0.78) for all perfusion parameters. Average values of perfusion parameters were higher in untreated patients but remained abnormally elevated in treated patients as well. Perfusion data and ESR and CRP correlated well both in aortitis (p , 0.05) and in periaortitis (p , 0.05). In periaortitis, perfusion parameters agreed well with ESR and CRP values (p , 0.05) only in untreated patients. Conclusion: Perfusion CT parameters in untreated aortitis and chronic periaortitis correlate well with serological markers with respect to disease activity assessment. However, in treated periaortitis, correlations were weak, suggesting an increased role for (perfusion-based) imaging. Advances in knowledge: Volume perfusion CT may be used for diagnosis of aortitis/periaortitis.

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Section: Discussionmentioning

confidence: 99%

Perfusion-based assessment of disease activity in untreated and treated patients with aortitis and chronic periaortitis: correlation with CT morphological, clinical and serological data

Bier¹,

Henes²,

Eulenbruch³

et al. 2015

BJR

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“…Late recurrences are possible and unpredictable and can occur within three months to more than 9 years regardless of the treatment, and are more frequent in the first 5 years thus requiring close and prolonged clinical, biological and radiological monitoring [ 25,31,37,48].…”

Section: Discussionmentioning

confidence: 99%

Retroperitoneal Fibrosis: Case Series of 20 Patients

Said¹,

Ghoundale²,

Zakaria³

et al. 2017

SJPH

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Abstract:Retroperitoneal fibrosis (RPF) is a rare disease. The objective of this paper is to study the prevalence, clinical, biological and radiological aspects of the RPFand to specify its therapeutic modalities. This study provides descriptive evidence for a series of 20 patients with RPF. We conducted a retrospective study of cases of RPF diagnosed in the Urology and Internal Medicine departments of the Ibn Sina Military Hospital in Marrakech over a five-year period from July 2010 to December 2015. The positive diagnosis of RPF was retained either on the basis of a histological analysis from a biopsy fragment or, in the absence of histological evidence, by the detection on a scan of an infiltrate or "sleeve" Regular and homogeneous tissue density, perivascular topography, surrounding the abdominal aorta, more or less extended to the iliac vessels and able to take the contrast after injection. They were 15 men and 5 women with an average age of 53 years with extremes of 41 to 74 years. Almost all patients had mainly lumbar and abdominal pain. An inflammatory syndrome existed in all cases and renal insufficiency in 15 cases. Radiological investigations showed unilateral or bilateral hydronephrosis in 16 cases. RPF was idiopathic in 14 patients. Secondary forms were present in 6 patients (three atheromatous diseases, one gastric tumor, one case associated with Riedel's thyroiditis and one case of systemic fibrosis associating RPF, Riedel's thyroiditis and liver fibrosis). The treatment consisted of corticosteroids in 19 cases, surgery in 17 cases associated with corticosteroid therapy or even immunosuppressant in the case of steroid-dependence. Two deaths were observed in this series; one of these two patients had developed cervix carcinoma with pleural and peritoneal metastases after 5 years of immunosuppressive therapy. The second died due to the complications of his gastric neoplasm. The general characteristics of patients included are similar to the other series of the literature. The frequency of secondary forms seems to be underestimated, hence the value of a rigorous etiological investigation. The therapeutic strategy and the use of the cortisone saving treatments should be specified by randomized therapeutic trials. The prognosis is generally good; however, the possibility of recurrences, the incidence of which is greater during the first five years, requires prolonged clinical, biological and radiological monitoring.

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“…[4][5][6][7][8][9][10][11][12] In our case, we describe a different pattern of tumor thrombus in the entire length of left ovarian arteries and veins, which appears similar to the findings of retroperitoneal fibrosis on FDG PET/CT as previously described. [13][14][15][16][17][18] …”

Section: Figurementioning

confidence: 99%

FDG PET/CT Appearance of Tumor Thrombus of Ovarian Vessels Masquerading as Retroperitoneal Fibrosis

Luo

Feng²,

Li³

2015

Clinical Nuclear Medicine

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A 23-year-old woman with recurrent uterine endometrial stromal sarcoma underwent FDG PET/CT, which showed pelvic recurrence and multiple pulmonary metastases. In addition, increased activity in a vertical soft tissue mass along the left ureter was noted, which appears similar to retroperitoneal fibrosis on PET/CT images. However, pathological examination demonstrated that the elevated FDG activity in this mass was a result of tumor thrombus from endometrial stromal sarcoma in the left ovarian arteries and veins.

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The value of 18F-FDG PET/CT in the assessment of active idiopathic retroperitoneal fibrosis

Abstract: (18)F-FDG PET/CT may be considered an alternative imaging method for the assessment of different stages of IRF.

Cited by 42 publications

References 19 publications

Perfusion-based assessment of disease activity in untreated and treated patients with aortitis and chronic periaortitis: correlation with CT morphological, clinical and serological data

Perfusion-based assessment of disease activity in untreated and treated patients with aortitis and chronic periaortitis: correlation with CT morphological, clinical and serological data

Retroperitoneal Fibrosis: Case Series of 20 Patients

FDG PET/CT Appearance of Tumor Thrombus of Ovarian Vessels Masquerading as Retroperitoneal Fibrosis

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