The value of a formula including haematocrit, blood urea and gender (HUGE) as a screening test for chronic renal insufficiency

Alvarez-Gregori, Joaquin; Robles, Nicolás Roberto; Mena, Candido; Ardanuy, Ramón; Jauregui, Ricardo; Macías-Núñez, Juan F.

doi:10.1007/s12603-011-0001-0

Cited by 32 publications

(12 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This formula offers a fast screening method that is safe and economical and has high sensitivity (93%), specificity (93%), positive predictive value (96%), and negative predictive value (88%). 12 However, external validation of this accuracy is needed.…”

Section: Discussionmentioning

confidence: 99%

“…The HUGE is calculated as 2.505458 À (0.264418 Â hematocrit) þ (0.118100 Âurea), þ1.383960 if male, 12 where if the result is <0, the individual is not renal insufficient and if the result is >0, the patient has a high probability of developing chronic renal failure.…”

Section: Hematocrit Urea and Gendermentioning

confidence: 99%

“…However, validation of these is limited in people older than 70 years, and the prognostic implications of these surrogate markers of kidney function are not well determined. 11 The hematocrit, urea, and gender (HUGE) formula was designed to differentiate age-related renal changes from chronic renal failure in patients older than 70 years 12 and has been validated as a prognostic indicator in patients with diabetic nephropathy. 13 The aim of this study was to analyze whether the indirect measurement of renal function by the HUGE formula is useful as a prognostic indicator in older patients with hip fracture.…”

Section: Introductionmentioning

confidence: 99%

“…The hematocrit, urea, and gender (HUGE) formula was designed to differentiate age-related renal changes from chronic renal failure in patients older than 70 years 12 and has been validated as a prognostic indicator in patients with diabetic nephropathy. 13…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinical Impact of Indirect Markers of Renal Function in Elderly Patients With Hip Fracture

López-Martínez

Tovar-Rivera

Becerra-Laparra

et al. 2014

Geriatr Orthop Surg Rehabil

View full text Add to dashboard Cite

Introduction: There are risk factors associated with mortality in patients older than 70 years with hip fracture, including kidney function. However, indirect formulas to calculate glomerular filtration rate are not validated in patients older than 70 years. We analyzed whether the formula hematocrit, urea, and gender (HUGE) can be used as a prognostic factor. Material and Methods: A retrospective cohort study of 88 patients older than 70 years with a diagnosis of hip fracture. At admission, clinical and biochemical parameters were measured and glomerular filtration rate by Cockcroft-Gault, Modification Of Diet In Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), and HUGE value. Accuracy to assess long-term mortality was analyzed with receiver-operating curve analysis. Cox regression analysis was performed to identify risk factor for mortality. Results: Sample included 88 patients; overall mortality was 13.63%, 17.85%, 28.57%, and 75.85% at 6 months, 1, 2, and 3 years, respectively. There was no significant difference in glomerular filtration rate by different formulas, contrary to HUGE, with higher values in the mortality group (1.83 + 6.38 vs À2.61 + 2.70, P ¼ .0001). Survival was lower in patients with higher HUGE values (22.7 months, 95% confidence interval [CI] 16.1-29.5 vs 32.9 months, 95% CI 30.2-35.7; P .001). In the Cox regression analysis, a negative HUGE value is associated with lower mortality (hazards ratio ¼ 0.238; 95% CI 0.568-0.099). Conclusion: The HUGE formula is an independent risk factor for mortality in elderly patients with hip fracture, but not the glomerular filtration rate determined by Cockcroft-Gault, MDRD, and CKD-EPI.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Hematocrit Urea and Gendermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Impact of Indirect Markers of Renal Function in Elderly Patients With Hip Fracture

López-Martínez

Tovar-Rivera

Becerra-Laparra

et al. 2014

Geriatr Orthop Surg Rehabil

View full text Add to dashboard Cite

show abstract

“…There-fore, the suitability of a cut-off value of eGFR less than 60 mL/ min/1.73 m 2 as the cut-off for CKD in the elderly is debatable 12,13,14 . Therefore, the HUGE equation was derived to determine presence of CKD without considering the patient's GFR that which is important in the elderly where reduced eGFR as already mentioned, does not always mean the presence of CKD 15 . Our aim was to analyze in a group of subjects older than 70 years the differences in CKD prevalence and eGFR stages using CKD EPI and BIS1 equations and to distinguish the presence of normal kidney aging from CKD using the HUGE equation.…”

Section: Berlin Initiative Study 1 Equation and Huge Formula For More Accurate Estimation Of Kidney Function In Elderlymentioning

confidence: 99%

Berlin Initiative Study 1 equation and HUGE formula for more accurate estimation of kidney function in elderly

Matašin¹,

Domislović²,

Fuček³

et al. 2021

Rad Hrvatske akademije znanosti i umjetnosti

View full text Add to dashboard Cite

Introduction: Chronic kidney disease (CKD) is one of the leading public health problems and a significant concern in the elderly population. Assessment of renal function in elderly is difficult due to the physiological decline of GFR with aging. Furthermore, recommended eGFR CKD EPI equation has not been validated in the elderly. Our aim was to analyze in a group of subjects older than 70 years the differences in CKD prevalence and eGFR stages using CKD EPI and BIS1 equations (validated in elderly) and to distinguish the presence normal kidney aging from CKD using the HUGE equation. Materials and Methods: This cross-sectional observational study included 383 subjects older than 70 years who were part of ENAH study (N=2193). CKD was defined as an eGFR <60mL/min/1.73m 2 ; CKD stages were classified according to the KDIGO guidelines. The eGFR was calculated using CKD EPI and BIS1 equation. The HUGE equation was calculated in subset of 75 subjects. Results: The average age of the study population was 75 years. BIS1 classified 22.7% subjects more to a GFR <60 mL/min/1.73m 2 than CKD EPI. A systematic difference was found between the equations, with BIS1 mean value being lower for 8.0 mL/min than that of CKD EPI. Less falsely CKD (8.6% subjects) i.e. more normal kidney aging was detected using BIS1 instead of CKD EPI equation. Conclusions: The prevalence of CKD was higher with BIS1 than with CKD EPI equation i.e. CKD EPI underestimated CKD prevalence in elderly. More accurate diagnosis of CKD, and better determination of CKD prevalence in subjects older than 70 years could be obtained using BIS1 equation with addition of HUGE equation.

show abstract

Renal Aging and Chronic Kidney Disease in the Elderly: Which Are the Differences?

Musso

Macías-Núñez

2019

Clinical Nephrogeriatrics

View full text Add to dashboard Cite

The value of a formula including haematocrit, blood urea and gender (HUGE) as a screening test for chronic renal insufficiency

Cited by 32 publications

References 14 publications

Clinical Impact of Indirect Markers of Renal Function in Elderly Patients With Hip Fracture

Clinical Impact of Indirect Markers of Renal Function in Elderly Patients With Hip Fracture

Berlin Initiative Study 1 equation and HUGE formula for more accurate estimation of kidney function in elderly

Renal Aging and Chronic Kidney Disease in the Elderly: Which Are the Differences?

Contact Info

Product

Resources

About