The value of exosomes in patients with laryngeal or hypopharyngeal cancer

Jia, Yuan-Jing; You, Huihua; Zhou, Shi‐Ping

doi:10.2306/scienceasia1513-1874.2021.013

Cited by 3 publications

(2 citation statements)

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“…They are enclosed by a phospholipid bilayer and safeguard and convey various cargoes such as nucleic acids, diverse forms of proteins, and a unique range of lipids [ 152 , 153 ] ( Figure 4 D). Exosomes can be secreted by different types of cells, including tumor cells, and are typically 30–100 nanometers in size [ 154 ]. Their unique structure and composition make them valuable for a range of applications.…”

Section: Nano-ddss In Oc Therapymentioning

confidence: 99%

Nano-Drug Delivery Systems in Oral Cancer Therapy: Recent Developments and Prospective

Zhang,

Wu,

et al. 2023

Pharmaceutics

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Oral cancer (OC), characterized by malignant tumors in the mouth, is one of the most prevalent malignancies worldwide. Chemotherapy is a commonly used treatment for OC; however, it often leads to severe side effects on human bodies. In recent years, nanotechnology has emerged as a promising solution for managing OC using nanomaterials and nanoparticles (NPs). Nano-drug delivery systems (nano-DDSs) that employ various NPs as nanocarriers have been extensively developed to enhance current OC therapies by achieving controlled drug release and targeted drug delivery. Through searching and analyzing relevant research literature, it was found that certain nano-DDSs can improve the therapeutic effect of drugs by enhancing drug accumulation in tumor tissues. Furthermore, they can achieve targeted delivery and controlled release of drugs through adjustments in particle size, surface functionalization, and drug encapsulation technology of nano-DDSs. The application of nano-DDSs provides a new tool and strategy for OC therapy, offering personalized treatment options for OC patients by enhancing drug delivery, reducing toxic side effects, and improving therapeutic outcomes. However, the use of nano-DDSs in OC therapy still faces challenges such as toxicity, precise targeting, biodegradability, and satisfying drug-release kinetics. Overall, this review evaluates the potential and limitations of different nano-DDSs in OC therapy, focusing on their components, mechanisms of action, and laboratory therapeutic effects, aiming to provide insights into understanding, designing, and developing more effective and safer nano-DDSs. Future studies should focus on addressing these issues to further advance the application and development of nano-DDSs in OC therapy.

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Section: Nano-ddss In Oc Therapymentioning

confidence: 99%

Nano-Drug Delivery Systems in Oral Cancer Therapy: Recent Developments and Prospective

Zhang,

Wu,

et al. 2023

Pharmaceutics

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“…Nasopharyngeal carcinoma [1] and laryngeal or hypopharyngeal cancer [2] are throat cancers with highly prevalence in Southeast Asia and Southern China. Although nasopharyngeal carcinoma cells are sensitive to radiation, chemotherapy and radiotherapy are the preferred strategy for its treatment, and the 5-year survival rate of patients with this cancer at early stage is up to 80% [3].…”

Section: Introductionmentioning

confidence: 99%

UNC119 promotes the malignant progression of nasopharyngeal carcinoma cells by regulating Wnt/β-catenin pathway

Hong¹,

Mao²,

Huang³

2022

ScienceAsia

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UNC119, also known as human retinal gene 4 (HRG4), has been found to contribute to the tumorigenesis of hepatocellular carcinoma. However, the role and mechanism of UNC119 in nasopharyngeal carcinoma has not been systematically investigated yet. Data from western blot and RT-qPCR assays showed that UNC119 was elevated in nasopharyngeal carcinoma cells and tissues. Functional assays demonstrated that transfection with siRNA targeting UNC119 reduced cell viability and suppressed proliferation, invasion, and migration of nasopharyngeal carcinoma cells. Moreover, silence of UNC119 decreased the protein expressions of N-cadherin and vimentin while, on the other hand, increased the protein expressions of E-cadherin and zonula occludes-1 (ZO-1) to suppress epithelial-mesenchymal transition in nasopharyngeal carcinoma. The protein expressions of Axin2 and adenomatous polyposis coli (APC) were up-regulated, while β-catenin and matrix metalloproteinase-7 (MMP-7) were down-regulated by silence of UNC119 in nasopharyngeal carcinoma cells. In conclusion, knockdown of UNC119 suppressed cell growth and metastasis, and repressed epithelial-mesenchymal transition in nasopharyngeal carcinoma through inactivation of Wnt/β-catenin pathway.

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Exosomics in oral cancer diagnosis, prognosis, and therapeutics – An emergent and imperative non-invasive natural nanoparticle-based approach

Bano

Vats

Yadav

et al. 2022

Critical Reviews in Oncology/Hematology

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The value of exosomes in patients with laryngeal or hypopharyngeal cancer

Cited by 3 publications

References 0 publications

Nano-Drug Delivery Systems in Oral Cancer Therapy: Recent Developments and Prospective

Nano-Drug Delivery Systems in Oral Cancer Therapy: Recent Developments and Prospective

UNC119 promotes the malignant progression of nasopharyngeal carcinoma cells by regulating Wnt/β-catenin pathway

Exosomics in oral cancer diagnosis, prognosis, and therapeutics – An emergent and imperative non-invasive natural nanoparticle-based approach

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