The value of FDP/FIB and D-dimer/FIB ratios in predicting high-risk APL-related thrombosis

Bai, Yanliang; Shi, Mingyue; Yang, Xinrong; Zhang, Wanjun; Yang, Ruyu; Wei, Xiuli; Wei, Xudong; Duan, Li; Wang, Chenghua; Mi, Ruihua; Ahmed, Hafiz Abdul Waqas; Huo, Lei; Chen, Yuqing; Xu, Fangfang; Wu, Depei; Sun, Kai

doi:10.1016/j.leukres.2019.02.007

Cited by 26 publications

(18 citation statements)

References 10 publications

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“…Among COVID-19 patients, 5 (13.5%) had elevated D-di-mer, and 17 (45.9%) had elevated Fib-C. The increase in Fib-C indicated possibilities of blood coagulation; therefore, there is a need to pay close attention to the risk of deep vein thrombosis [15,16]. Elevated D-dimer is often used as an indicator of pulmonary embolism, but it can also be elevated in inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 disease: novel clinical manifestations and therapeutic exploration

et al. 2020

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Introduction: This study aims to provide further clarifications on some new clinical characteristics of COVID-19 recently discovered by our research group. Material and methods: In this single-centred, retrospective study, we collected all confirmed cases of COVID-19 diagnosed in Dazhou, Sichuan, China from January 23 to February 25, 2020. All the cases were either imported from Wuhan or transmitted in family clusters. We analysed general information on all patients. Meanwhile, the contents of lactic acid, Fib-C, and D-dimer in the serum of patients were detected. Results: The study included 37 patients diagnosed as having COVID-19, the average age of the patients was 45.76 ±13.1 years. The average positive time of nucleic acid in pharyngeal swabs was 20.65 ±6.7 days. A total of 4 (10.8%) patients were asymptomatic. On serological examination, 33 (89.1%) patients had increased lactic acid, 17 patients had increased fibrinogen C (Fib-C), and 5 patients had increased D-dimer. Of all patients, 29 were positive for COVID-19-specific antibodies. We also detected COVID-19 nucleic acid in faecal specimens from 4 patients. Klebsiella pneumoniae was found in the sputum of 1 patient. A total of 4 patients received psychological intervention. Lopinavir/ritonavir and Abidol may not be effective in treating COVID-19. Conclusions: In the serum of most COVID-19-infected patients, lactic acid was higher than normal, and COVID-19-specific antibody was positive. Fib-C and D-dimer in the serum of some infected patients increased. Lopinavir/ ritonavir and Abidol have little effect on shortening the positive time of viral nucleic acid in patients.

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Section: Discussionmentioning

confidence: 99%

COVID-19 disease: novel clinical manifestations and therapeutic exploration

et al. 2020

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“…However, there were some published reports suggesting some clues of the quantitative relationship between D‐dimer and FDP. FDP and D‐dimer levels were comparable in septic patients, plasma FDP showed a linear association with the D‐dimer level ( R 2 = 0.628, P < 0.001) in immune‐deficient mice models, the value of FDP/fibrinogen and D‐dimer/fibrinogen ratios that could predict high‐risk APL related thrombosis were significant, and the International Society on Thrombosis and Hemostasis criteria for overt DIC use a DIC scoring system based on the combined results of coagulation tests included FDP/D‐dimer ratio (2019) . As such, we considered it might be acceptable to use the conversion values of D‐dimer to those of FDPs in this preliminary retrospective analysis.…”

Section: Discussionmentioning

confidence: 80%

New method for determining fibrinogen and FDP threshold criteria by artificial intelligence in cases of massive hemorrhage during delivery

Miyagi

Tada

Yasuhi

et al. 2019

J of Obstet and Gynaecol

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Aim: To investigate the feasibility of a novel method using artificial intelligence (AI), in which the fibrinogen criterion was determined by the quantitative relation between the distributions of fibrin/fibrinogen degradation products (FDPs) and fibrinogen. Methods: A dataset of 154 deliveries comprising more than 2000 g of blood lost due to hemorrhage, excluding disseminated intravascular coagulation (DIC), among patients from eight national perinatal centers in Japan from 2011 to 2015 were obtained. The fibrinogen threshold criterion was identified by using the function that best fit the distributions of FDP as determined by AI. FDP production was described by differential equations using a dataset containing fibrinogen levels less than the fibrinogen criterion and solved numerically. Results: A fibrinogen level of 237 mg/dL as the threshold criterion was obtained. The FDP threshold criteria were 2.0 and 8.5 mg/dL for no coagulopathy and a failed coagulation system, respectively. Conclusion: The fibrinogen threshold criterion for patients with massive hemorrhage excluding DIC at delivery were obtained by selecting the functions that best fit the distributions of FDP data by using AI.

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“…D-dimer levels in patients with DVT are significantly higher than those in the control group. 23 – 25 However, D-dimer levels do not necessarily indicate the presence of thrombosis, especially for patients older than 80 years in whom the D-dimer threshold should be increased. 26 D-dimer levels of the patients in our study were significantly higher than normal values, and D-dimer levels in the unstable group were significantly higher than those in the stable group.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of stability of deep venous thrombosis of the lower extremities using Doppler ultrasound

et al. 2020

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Objective This study aimed to assess using Doppler ultrasound for analyzing stability of deep venous thrombosis (DVT) of the lower extremities. Methods Patients with DVT of the lower extremities who were treated from August 2017 to December 2019 were selected. The patients were divided into stable and unstable groups according to whether thrombus was collected in a filter. Related ultrasound and blood test results were analyzed and compared. Results A total of 126 patients with DVT of the lower extremities were included, of whom 74 were in the stable group and 52 were in the unstable group. There were significant differences in the prothrombin time (PT), and lipoprotein alpha, D-dimer, and triglyceride levels between the groups. D-dimer levels >2800 ug/L, smoking, history of venous thrombosis, PT >13.15 s, and body mass index >24.45 kg/m2 were independent risk factors for stability of DVT of the lower extremities. The area under the curve with combined detection of DVT was significantly higher than that for body mass index, PT, and D-dimer alone. Conclusion Doppler ultrasound may be reliable for analyzing the stability of DVT of the lower extremities. Related strategies targeting risk factors are required for reducing DVT of the lower extremities.

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The value of FDP/FIB and D-dimer/FIB ratios in predicting high-risk APL-related thrombosis

Cited by 26 publications

References 10 publications

COVID-19 disease: novel clinical manifestations and therapeutic exploration

COVID-19 disease: novel clinical manifestations and therapeutic exploration

New method for determining fibrinogen and FDP threshold criteria by artificial intelligence in cases of massive hemorrhage during delivery

Evaluation of stability of deep venous thrombosis of the lower extremities using Doppler ultrasound

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