The value of inhalation tests in perennial bronchial asthma

Popa, Valentin; Teculescu, D; Stănescu, Dan; Gavrilescu, N.

doi:10.1016/0021-8707(68)90086-5

Cited by 23 publications

(12 citation statements)

References 19 publications

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“…The presence of wheezing during mild, acute airway obstruction [6,31] or during breathing at low lung volume (i.e., AR) -where the airways narrow -is not unexpected. Nor is the variable degree of airway obstruction at which acute wheezing may appear in different subjects [8,32] (fig-!…”

Section: Discussionmentioning

confidence: 99%

“…Body plethysmography was used to check the persistence of volume and airway resistance changes in S, as compared to S,; changes in both measurements might have been missed if only the dilution or flow-volume curves, respectively, had been recorded. The presence of wheezing was assessed clinically [6][7][8] during tidal breathing before and after DD.…”

Section: Physiologic Measurementsmentioning

confidence: 99%

“…congestive heart failure (by clinical and radiologic criteria), left ventricular hypertrophy (by ECG and chest x-ray), hiatal hernia and/or gastroesophageal reflux (14/23 had an upper gastrointestinal study), pleural and neuromuscular dis eases, marked obesity, or thoracic deformities. (6) No present treat ment with steroids, antihistaminic or anticholinergic agents and no evidence of wheezing prior to the physiologic recordings.…”

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confidence: 99%

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Wheezing Triggered by Dorsal Decubitus: Pulmonary Function Changes

Popa

Zumstein²

1993

Respiration

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In 23 subjects with chronic obstructive pulmonary disease (COPD) who wheezed when changing their position from sitting to dorsal decubitus (DD), we recorded lung volumes and flow volume loops in sitting (S₁), DD and immediately after resuming sitting (S₂). We found three main patterns of ventilatory changes associated with wheezing in DD: (1) acute obstruction (AO) in 14 subjects characterized by FEV₁≥-10% and % FEV₁/FVC≥-3%; functional residual capacity or residual volume was increased, decreased or unchanged; (2) acute restriction (AR) in 7 subjects characterized by absence of obstruction spirographically and FVC and/or FRC > -10%; (3) indeterminate response (IR) in 2 subjects. Except for 3 subjects, the changes recorded in DD returned to baseline in S₂. Both AO and AR responses in DD and their rapid resolution in S₂ were reproducible (11 subjects). In conclusion: (1) in COPD, DD may trigger wheezing; (2) the physiologic changes during DD wheezing are reproducible, rapidly reversible when the sitting position is resumed and unlike those recorded during bronchoprovocation, heterogeneous.

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Section: Discussionmentioning

confidence: 99%

Section: Physiologic Measurementsmentioning

confidence: 99%

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Wheezing Triggered by Dorsal Decubitus: Pulmonary Function Changes

Popa

Zumstein²

1993

Respiration

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“…2) Anamnesis and skin tests are not sufficient wben studying the part played in flour allergy by its contaminants (arthropodes, fungi, bacteria). 3) In occupational respiratory allergy, challenge tests reproducing the spontaneous complaints are tbe most convincing diagnostic procedures (30,31)-Modern equipment diminisbcd considerably the incidence of allergy to flour (33), utilization of persulfate (41) was I 60 prohibited in most countries, but allergic bakers still exist since contact with flour dust is difficult to prevent.…”

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confidence: 99%

Occupational and Non Occupational Respiratory Allergy in Bakers

Popa¹,

George²,

Găvănescu³

1970

Allergy

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Allergy to flour was studied by many autbors (2, 3, 4, 7, 9, 16, 29, I,!,, 35, 39, etc.). However, few investigators used cballenge tests as a diagnostic tool (20,23,35,36). To us, challenge tests appeared particularly indicated in studying the allergy to flour since. 1) Many if not most allergic bakers display concomitant positive skin tests to various allergens (4, 5, 9, 16, 20, 29, •},2, 40) ; in these subjects a careful anamnesis could occasionally distinguish between latent and manifest allergy. For instance, in bakers with paroxysmal dyspnea occurring only at the working place, a concomitant positive skin test to bouse dust expresses only a latent allergy; but in bakers with asthma attacks both at work and at home (even during holidays or leaves), allergic etiology may be diflicult to assess. 2) Anamnesis and skin tests are not sufficient wben studying the part played in flour allergy by its contaminants (arthropodes, fungi, bacteria). 3) In occupational respiratory allergy, challenge tests reproducing the spontaneous complaints are tbe most convincing diagnostic procedures (30, 31)-Modern equipment diminisbcd considerably the incidence of allergy to flour (33), utilization of persulfate (41) was

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“…Many reports have shown a poor correlation between skin testing and bronchial challenge [12][13][14]. Other investigators have reported some association between positive provocation tests and the degree of skin sen sitivity [15][16][17][18][19][20][21],…”

Section: Introductionmentioning

confidence: 99%