The value of lipopolysaccharide binding protein for diagnosis of late-onset neonatal sepsis in very low birth weight infants

Leante-Castellanos, José Luis; Guadiana-Romualdo, Luis García de; Fuentes-Gutiérrez, Carmen; García-González, Ana; Jiménez-Santos, Enrique

doi:10.1515/jpm-2014-0010

Cited by 14 publications

(8 citation statements)

References 3 publications

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“…[19–21] Currently, sCD14-ST level has been reported as an index for diagnosis and evaluation of hematosepsis in the infant with a low birth weight. [22] As there are only a few infants with a low birth weight among the subjects of this study, the above-mentioned report is not supported and further research on a large quantity of samples collected from infants with different birth weights is yet to be conducted.…”

Section: Discussionmentioning

confidence: 82%

The clinical significance of sCD14-ST for blood biomarker in neonatal hematosepsis

Xiao¹,

Chen²,

Zhang

et al. 2017

Medicine

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Hematosepsis is a systemic inflammatory response syndrome (SIRS) with suspected or confirmed infection, which is the most common infectious disease in clinical neonatal intensive care unit. As the rapid development of neonatal hematosepsis caused by various basic diseases, the mortality rate is high, and there are some sequelae.We report the lasted study to date with 96 cases from Fujian Longyan First Hospital between 2013 and 2015. The aim of our study is to explore the value of soluble cluster of differentiation 14 subtype (sCD14-ST) in whole blood for differential diagnosis of neonatal hematosepsis at an early stage, and used in evaluation of the severity about sepsis combined with acute physiology and chronic health evaluation II (APACHE-II) score, procalcitonin (PCT), C reactive protein (CRP), and leukocyte (WBC).In our cohort, all cases met the diagnostic criteria for hematosepsis specific for newborns. We selected 42 neonates with hematosepsis, 54 neonates with nonhematosepsis, 44 noninfectious SIRS neonates, and 53 healthy neonatal controls. Which were determined the sCD14-ST, PCT, CRP, and WBC of all samples before treatment. Then assign the APACHE-II score for the all samples before and after treatment.The study shows, sCD14-ST levels were significantly higher in hematosepsis than nonhematosepsis group (t = −2.112, P = .041). Meanwhile, sCD14-ST levels were significantly higher in neonatal hematosepsis than in noninfectious SIRS group and controls (χ2 = 57.812, 68.944, P < .01). However, sCD14-ST in hematosepsis group was positively correlated with APACHE-II score (R-value = 0.415, P < .01). During treatment, the sCD14-ST level was decreased obviously along with APACHE-II score, PCT, CRP, and WBC (χ2 = 35.019, 78.399, 52.363, 25.912, 7.252, all P values <.01). The area under the curve (AUC) of sCD14-ST was 0.942. The differences in ROCAUC of sCD14-ST compared with PCT, CRP, and WBC were statistically significant (Z = −6.034, −4.474, −5.722, all P values <.01). The sensitivity and specificity of sCD14-ST were 95.2% and 84.9%, respectively.sCD14-ST could be a blood biomarker for early identification and disease valuation in newborns hematosepsis infection; and its diagnostic value is superior to other laboratory indexes.

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Section: Discussionmentioning

confidence: 82%

The clinical significance of sCD14-ST for blood biomarker in neonatal hematosepsis

Xiao¹,

Chen²,

Zhang

et al. 2017

Medicine

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“…In humans, LBP triggers a dynamic endotoxin (such as LPS) transfer cascade by binding and transferring LPS to CD14, which transfer LPS to TLR4-MD-2 receptors on immune cells; LBP thereby concentrates LPS at the cell membrane of immune cells to stimulate an inflammatory response [40]. LBP also recognizes pathogens such as spirochaeta, mycobacteria, gram-positive bacteria and mycoplasma [41]. LBP binds pro-inflammatory constituents of both Gram positive and Gram negative bacteria [42], making it a more general marker of, bacterial exposures than LPS that stems only from Gram negative bacteria [38].…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of inflammation – LBP and TLR— predict progression of knee osteoarthritis in the DOXY clinical trial

Huang

Perry

Huebner

et al. 2018

Osteoarthritis and Cartilage

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“…16 However, owing to the limitations of currently available biomarkers, such as CRP and PCT, 4 further efforts are needed to identify the novel biomarkers of infection. Previous studies have demonstrated the utility of LBP as a predictor of infection in patients with febrile neutropenia, 17 and of bacteraemia in children with community-acquired infection 1 and for diagnosing of late-onset neonatal sepsis 18,19 and febrile urinary tract infection in children. 20 In this study, we have analysed the value of LBP, measured on admission, for diagnosis of sepsis in patients admitted to the ED with suspected infection, compared with CRP and PCT.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of lipopolysaccharide-binding protein for sepsis in patients with suspected infection in the emergency department

et al. 2017

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Background Biomarkers can facilitate the diagnosis of sepsis, enabling early management and improving outcomes. Lipopolysaccharide-binding protein (LBP) has been reported as a biomarker for the detection of infection, but its diagnostic value is controversial. In this study, we assessed the diagnostic accuracy of LBP for sepsis in the emergency department (ED) patients, comparing it with more established biomarkers of sepsis, including procalcitonin (PCT) and C-reactive protein (CRP). Methods LBP and other sepsis biomarkers, including PCT and CRP, were measured on admission in 102 adult patients presenting with suspected infection . Classification of patients was performed using the recently updated definition for sepsis (Sepsis-3). The diagnostic accuracy of LBP, CRP and PCT for sepsis was evaluated by using receiver operating characteristic curve (ROC) analysis. Results A total of 49 patients were classified as having sepsis. In these patients, median (interquartile range) LBP (41.8 [41.1] µg/dL vs. 26.2 [25] µg/dL), CRP (240 [205] mg/L vs. 160 [148] mg/dL) and PCT (5.19 [13.68] µg/L vs. 0.39 [1.09] µg/L) were significantly higher than in patients classified as not having sepsis ( P < 0.001 for all three biomarkers). ROC curve analysis and area under curve (AUC) revealed a value of 0.701 for LBP, similar to CRP (0.707) and lower than that for PCT (0.844) ( P = 0.012). Conclusion In adult ED patients with suspected infection, the diagnostic accuracy for sepsis of LBP is similar to that of CRP but lower than that of PCT.

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The value of lipopolysaccharide binding protein for diagnosis of late-onset neonatal sepsis in very low birth weight infants

Abstract: Serum LBP measurement may be useful as an additional tool in the evaluation of suspected LONS in VLBW infants.

Cited by 14 publications

References 3 publications

The clinical significance of sCD14-ST for blood biomarker in neonatal hematosepsis

The clinical significance of sCD14-ST for blood biomarker in neonatal hematosepsis

Biomarkers of inflammation – LBP and TLR— predict progression of knee osteoarthritis in the DOXY clinical trial

Diagnostic accuracy of lipopolysaccharide-binding protein for sepsis in patients with suspected infection in the emergency department

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