The value of neutrophil and lymphocyte count in frail older women

Fernández-Garrido, Julio; Navarro-Martínez, Rut; Buigues-GonzÁlez, Cristina; Martínez-Martínez, Mary; Ruiz-Ros, Vicente; Cauli, Omar

doi:10.1016/j.exger.2013.11.019

Cited by 49 publications

(41 citation statements)

References 44 publications

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“…In the cardiac surgery population, age and other co-morbidities were similar between these three frailty groups, except the incidence of stroke in the medical history (prior to surgery), which was a higher in the frail group. These findings support the notion that frailty is not strictly related to biological age and that the number of comorbidities does not fully correlate with their severity (Afilalo et al, 2012;Farhat et al, 2012;Fernández-Garrido et al, 2014a;Fried et al, 2004;Partridge et al, 2012;Robinson et al, 2013) As the frailty burden increases, the occurrence of one or more complications are more likely. Robinson et al (2013) reported that infection was the most common complication in both surgical groups, and perhaps related to this, a decrease in immune function has also been described in frail individuals (Furlan et al, 2013;Heffernan et al, 2012;Leng et al, 2009;Reddan et al, 2003).…”

Section: Grade IIIsupporting

confidence: 68%

Frailty syndrome and pre-operative risk evaluation: A systematic review

Buigues

Juarros-Folgado

Fernández-Garrido

et al. 2015

Archives of Gerontology and Geriatrics

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Section: Grade IIIsupporting

confidence: 68%

Frailty syndrome and pre-operative risk evaluation: A systematic review

Buigues

Juarros-Folgado

Fernández-Garrido

et al. 2015

Archives of Gerontology and Geriatrics

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“…Another study investigating the relationship between inflammation and frailty demonstrated that high WBCs counts were associated with increased frailty prevalence in community-dwelling older women, and the next study with the same cohort found that neutrophil and monocyte counts were positively related to frailty. Moreover, in a crosssectional study involving older patients, high neutrophil and low lymphocyte counts were associated with low physical activity, whereas low lymphocyte counts were associated with poor muscle strength (29)(30)(31). In our study, while the total WBCs count was not elevated in the frail group, neutrophil/lymphocyte ratio increased significantly.…”

Section: Discussionsupporting

confidence: 44%

Relationship Between Frailty and Inflammation

Doğrul¹,

Varan²,

Kılıç³

et al. 2019

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It has been suggested that inflammation plays a role in the pathogenesis of frailty and many studies have been carried out to understand the underlying mechanism. In this study, the relationship between frailty and inflammation was examined. Materials and Methods: Eight hundred and seventeen patients over 65 years of age were evaluated in this study. Comprehensive geriatric assessment was performed in each patient and the Fried frailty criteria were used to assess physical frailty. Neutrophil count, lymphocyte count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), albumin, mean platelet volume and CRP-to-albumin ratio (CAR) and neutrophil-tolymphocyte ratio (NLR) were recorded as inflammatory markers. Results: The median age of the patients was 73 years (minimum-maximum: 65-94). 61.9% of patients were female (n=506) and 10.8% were frail (n=88). The median CRP was 0.49 mg/L (minimum-maximum: 0.10-7.67) in frail group (p=0.167). The CAR was higher in the frail group but there was no significant correlation between high CAR and frailty (p=0.07). The median NLR was 2.17 (minimum-maximum: 0.21-10.17) in the non-frail group and 2.41 (minimum-maximum: 0.62-18.20) in the frail group and the difference between the two groups was significant (p=0.014). ESR was significantly higher in the frail group (p<0.001). In multivariate analysis, when models with independently related factors were studied, ESR was found to be significantly related with frailty (OR: 1.026, 95% CI: 1.005-1.047, p=0.015). Conclusion: Chronic inflammation has been shown to cause frailty directly or indirectly through its destructive effects on the musculoskeletal, respiratory, and hematological systems as well as other physiological intermediate systems. The findings of this study suggest that there may be a relationship between frailty and inflammation.

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“…In a very recent study, Fernández-Garrido and colleagues found a significant association between low physical activity and higher neutrophil and lower lymphocyte counts, whereas poor muscular strength (assessed by grip strength) was significantly correlated with lower lymphocyte counts in frail older women. Of note, to mention that the two subpopulations of WBC were within the physiological ranges (Fernandez-Garrido et al, 2014). In fact, there is no consensus regarding a cut-off point for inflammatory mediators to predict adverse physical and functional outcomes.…”

Section: Chronic Inflammationmentioning

confidence: 98%