The value of pancreatic stone protein in the prediction of infected neonates

Wu, Rongqian; Zha, Li; Hu, Jinhui; Wu, Jianming; Tian, Zengshan

doi:10.23736/s0026-4946.16.04317-x

Cited by 2 publications

(2 citation statements)

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“…A systematic search identi ed a total of 421 relevant articles. Having screened according to the Inclusion and Exclusion Criteria, 12 publications [20][21][22][23][24][25][26][27][28][29][30][31] were selected for inclusion in this meta-analysis. Of these, two studies, Nagwan et al [26] and Yok-Ai et al [31], each provided two data sets that met the inclusion criteria, resulting in a total of 14 data sets.…”

Section: Search Resultsmentioning

confidence: 99%

Pancreatic stone protein as a biomarkers for sepsis: a systematic review and meta-analysis

Zheng,

Guo,

Yang

et al. 2023

Preprint

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Backgroud The attack rate of the sepsis and its mortality is increasing rapidly in the world, with early diagnosis and prognosis being essential. Pancreatic stone protein (PSP) is regarded as an excellent indicator of detecting infection, which demonstrated a good diagnostic and prognostic value in sepsis. We utilized the meta-analysis method to further demonstrate the early diagnosis value and prognostic effectiveness of PSP in sepsis. Methods Relevant literature was systematically searched in PubMed, Ovid, Embase and ScienceDirect databases using medical subject headings and relevant diagnostic terms. All included literature was analysed using Stata 14.0 to calculate outcomes of pooled extracted data such as sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, area under the curve, diagnostic odds ratio and diagnostic score. Publication bias in the included studies was assessed using Deek's funnel plot. Cochrane Q statistic and I2 statistic were used to test for heterogeneity. Results A total of 12 studies were included in this analysis and the literature was divided into three groups based on the type of study: the ability of PSP to diagnose early adult/non-adult sepsis and the ability of PSP to predict mortality outcomes in paediatric sepsis. The combined results of sensitivity, specificity, positive likelihood ratios, negative likelihood ratios, area under the curve, diagnostic odds ratios and diagnostic scores indicated that PSP has good clinical value. No publication bias was found in any of the three meta-analyses. Conclusions Diagnosis and prognosis of sepsis by PSP has good accuracy and predictive value that warrants clinical promotion.

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Section: Search Resultsmentioning

confidence: 99%

Pancreatic stone protein as a biomarkers for sepsis: a systematic review and meta-analysis

Zheng,

Guo,

Yang

et al. 2023

Preprint

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show abstract

“…Searching for clinical studies of PSP and infection or sepsis in PubMed, we identified 1 prospective multicenter study, 29 20 prospective observational studies (Table 3 and 4), 2 meta-analyses, 30,31 2 literature reviews, 32,33 1 economic study, 34 2 technology study, 35,36 1 case report, 37 3 Covid-19 studies, [38][39][40] 1 book chapter, 41 2 point-of-view articles. 42,43 From the PubMed citations, we excluded 8 children studies, [44][45][46][47][48][49][50][51] 3 neonate studies, [52][53][54] 1 post-mortem study, 55 1 study in women for pregnancy-related disease, 56 1 PSP and diabetes study, 57 2 study protocols, 58,59 1 letter, 60 1 editorial, 61 4 comments, [62][63][64][65] and 1 published erratum. 66…”

Section: Pancreatic Stone Protein Clinical Studies For Infection and ...mentioning

confidence: 99%

Usefulness of pancreatic stone protein measurement to screen and diagnose sepsis in the context of the Surviving Sepsis Campaign recommendations.

Ventura,

Eggimann,

Daix

et al. 2023

MRAJ

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Sepsis occurs yearly in 48.9 million people worldwide of whom 11 million will die. Sepsis is defined as a life-threatening dysregulated reaction of the body in response to a bacterial infection, leading to organ dysfunction. The Surviving Sepsis Campaign (SSC) made numerous recommendations for sepsis diagnosis and treatment using an evidence-based medicine approach. Frequently, levels of evidence of these recommendations are poor and lack clear clinical guidance. Interestingly, the SSC guidelines strongly recommend, with a moderate quality of evidence, screening of nosocomial sepsis in acutely ill hospitalized “high-risk patients”. The definition of acutely ill and high-risk patients is not specified, nor it is indicated which tools should be used. The diagnosis of infection and the subsequent administration of antibiotics relies solely on rapid clinical assessment, as recommended by the Best Practice Statement. Again, the elements used for clinical assessment are poorly defined, encompassing patient history, clinical examination, and tests for both infectious and non-infectious causes of acute illness. In the real world, only 30 to 40% of empiric broad-spectrum antibiotic administrations are appropriate, contributing to the emergence of antimicrobial resistant bacteria, toxicity related to antibiotic administration, and costs. The aim of this review article is to show that the use of biomarkers, such as the Pancreatic Stone Protein (PSP) as an example, helps in guiding the clinician to diagnose and manage sepsis. Over 600 peer-reviewed publications have studied the physiology of PSP and more than 50 evaluated its usefulness to screen for the development of nosocomial sepsis and diagnose sepsis.

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The value of pancreatic stone protein in the prediction of infected neonates

Cited by 2 publications

References 0 publications

Pancreatic stone protein as a biomarkers for sepsis: a systematic review and meta-analysis

Pancreatic stone protein as a biomarkers for sepsis: a systematic review and meta-analysis

Usefulness of pancreatic stone protein measurement to screen and diagnose sepsis in the context of the Surviving Sepsis Campaign recommendations.

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