The value of perfusion CT in predicting the short-term response to synchronous radiochemotherapy for cervical squamous cancer

Abstract

• Perfusion CT can reflect tumour vascular physiology in cervical squamous carcinoma. • Perfusion CT helps predict the short-term effect before treatment • Synchronous radiochemotherapy may be more effective in patients with higher baseline BV and PS.

Value of R2* obtained from T2*‐weighted imaging in predicting the prognosis of advanced cervical squamous carcinoma treated with concurrent chemoradiotherapy

“…CONCURRENT CHEMORADIOTHERAPY HAS been a standard treatment for advanced cervical carcinoma . The prediction of treatment effect before therapy is very helpful for treatment option planning and to improve the prognosis . So far, several noninvasive functional imaging techniques, such as perfusion CT, apparent diffusion coefficient (ADC) derived from diffusion‐weighted imaging (DWI), pharmacokinetic parameters derived from dynamic contrast enhanced (DCE) MRI, have been introduced to predict the effect of chemoradiotherapy on cervical carcinoma .…”

Usefulness of Pseudocontinuous Arterial Spin-Labeling for the Assessment of Patients with Head and Neck Squamous Cell Carcinoma by Measuring Tumor Blood Flow in the Pretreatment and Early Treatment Period

“…7 In patients with HNSCC, the TBF is usually assessed by a dynamic contrast-enhanced method. [8][9][10][11] However, this method is somewhat invasive and requires IV placement and contrast injection, and repetitive scanning is sometimes difficult, especially during chemotherapy when renal dysfunction frequently occurs (approximately 25%-42%) in patients given cisplatin. 12,13 Because of the difficulties of repetitive scanning, there have been few studies of the changes in TBF with repetitive scanning over the treatment period, and the number of patients in these reports is quite small, at 10 to Ͻ20 patients.…”

Pilot study of combined FDG‐PET and dynamic contrast‐enhanced CT of locally advanced cervical carcinoma before and during concurrent chemoradiotherapy suggests association between changes in tumor blood volume and treatment response

“…Previous studies investigating perfusion CT in cervical cancer chemoradiotherapy used cine scanning with a fixed table position, which limited perfusion imaging to only a few slices covering 8‐20 mm of the tumor volume in axial direction 11, 12, 16. In contrast, using the recently introduced Adaptive 4D Volume Perfusion CT (Siemens, Erlangen, Germany) which employs continuous shuttling table motion, we could assess perfusion parameters throughout the tumor region.…”

“…Haider et al found correlations between DCE‐CT oxygen and blood flow (BF) measurements for cervical cancer tumors 11. High pretreatment values of perfusion blood volume (BV) and permeability correlate with favorable cervical tumor response to chemoradiation,12, 13 while low pretreatment cervical tumor perfusion on DCE‐MRI is associated with poor radioresponsiveness 14. These findings suggest pretreatment perfusion imaging has potential as a noninvasive prognostic tool for cervical cancer.…”