The Value of Safflower Yellow Injection for the Treatment of Acute Cerebral Infarction: A Randomized Controlled Trial

Li, Lejun; Li, Yumei; Qiao, Benyu; Jiang, Shan; Li, Xin; Du, Hong-Ming; Han, Pengcheng; Shi, Jiong

doi:10.1155/2015/478793

Cited by 13 publications

(12 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rare di-C-glycosides generally possess various bioactivities, and some have been used as clinical drugs in China, such as hydroxysafflor yellow A 40 . When excess sugar donors were provided, AbCGT showed high di-C-glycosylating activity with conversion rates of 100% to the acceptors (10, 11, and 16-19) with the unit of phloroglucinol.…”

Section: Resultsmentioning

confidence: 99%

Exploring and applying the substrate promiscuity of a C-glycosyltransferase in the chemo-enzymatic synthesis of bioactive C-glycosides

et al. 2020

View full text Add to dashboard Cite

Bioactive natural C-glycosides are rare and chemical C-glycosylation faces challenges while enzymatic C-glycosylation catalyzed by C-glycosyltransferases provides an alternative way. However, only a small number of C-glycosyltransferases have been found, and most of the discovered C-glycosyltransferases prefer to glycosylate phenols with an acyl side chain. Here, a promiscuous C-glycosyltransferase, AbCGT, which is capable of C-glycosylating scaffolds lacking acyl groups, is identified from Aloe barbadensis. Based on the substrate promiscuity of AbCGT, 16 C-glycosides with inhibitory activity against sodium-dependent glucose transporters 2 are chemo-enzymatically synthesized. The C-glycoside 46a shows hypoglycemic activity in diabetic mice and is biosynthesized with a cumulative yield on the 3.95 g L‒1 scale. In addition, the key residues involved in the catalytic selectivity of AbCGT are explored. These findings suggest that AbCGT is a powerful tool in the synthesis of lead compounds for drug discovery and an example for engineering the catalytic selectivity of C-glycosyltransferases.

show abstract

Section: Resultsmentioning

confidence: 99%

Exploring and applying the substrate promiscuity of a C-glycosyltransferase in the chemo-enzymatic synthesis of bioactive C-glycosides

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Through anti-inflammatory mechanisms, damage to the lung tissue of patients with sepsis and septic shock caused by inflammatory reaction may be reduced, and increases in permeability of blood capillaries may be inhibited. Safflower yellow may also act by blocking the cascade reaction of cytokines that are activated by this disease and thus inhibit activation and adhesion of neutrophils [ 12 , 13 , 21 ]. Leukocyte counts in the study group were significantly decreased as compared with those in the control group after treatment.…”

Section: Discussionmentioning

confidence: 99%

Effects of Safflower Yellow on the Treatment of Severe Sepsis and Septic Shock: A Randomized Controlled Clinical Trial

Wang

Kang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. To evaluate the clinical effect of safflower yellow on the treatment of severe sepsis and septic shock. Methods. 85 patients with severe sepsis and septic shock were randomly selected to receive either therapy according to the international guidelines for management of severe sepsis and septic shock (Surviving Sepsis Campaign 2012) (control group, n = 45) or conventional therapy plus safflower yellow (study group, n = 40). The 28-day mortality and 28-day Kaplan-Meier survival curves were compared as primary outcomes. Results. The 28-day mortality from all causes and in-hospital mortality were significantly lower in the study group (50%, 17.5%) as compared to the control group (78.58%, 54.76%) (P = 0.007, all causes, P < 0.001, in-hospital), and the 28-day Kaplan-Meier survival curve was higher in the study group than in the control group (P = 0.008, all causes, P < 0.001, in-hospital, Log Rank). 72 hours after treatment, secondary outcomes including heart rate, leukocyte counts, lactate levels, and platelet counts of patients in the study group were ameliorated significantly as compared with the control group. Conclusion. This study offers a potential new strategy employing safflower yellow to more effectively treat patients with severe sepsis and septic shock. This trial is registered with identifier ChiCTR-TRC-14005196.

show abstract

“…Safflower ( Carthamus tinctorius L.) is a herbaceous plant of the Asteraceae family, containing various active constituents, including flavonoids, quinochalcones, alkaloids, and safflower polysaccharides (SPS) [ 5 ]. Safflower exerts various biological effects, including antioxidant [ 6 ], anti-inflammatory [ 7 ], and antibacterial [ 8 ] activities, and is reported to be beneficial for the improvement of acute cerebral infarction [ 9 ] and ischemic stroke [ 10 ]. SPS is one of the most important active components of safflower, and accumulating evidences have supported the immuno-regulatory function and antitumor effect of SPS [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Safflower polysaccharide inhibits the development of tongue squamous cell carcinoma

et al. 2018

View full text Add to dashboard Cite

BackgroundSafflower polysaccharide (SPS) is one of the most important active components of safflower (Carthamus tinctorius L.), which has been confirmed to have the immune-regulatory function and antitumor effect. This study aimed to explore the effects of safflower polysaccharide (SPS) on tongue squamous cell carcinoma (TSCC).MethodsHN-6 cells were treated with 5 μg/mL cisplatin and various concentrations of SPS (0, 0.02, 0.04, 0.08, 0.16, 0.32, 0.64, and 1.28 mg/mL), and cell proliferation was measured. After treatment with 5 μg/mL cisplatin and 0.64 mg/mL SPS, the induction of apoptosis and the protein and mRNA expression of Bax, Bcl-2, COX-2, and cleaved caspase-3 in HN-6 cells were quantified. In addition, HN-6 cells were implanted into mice to establish an in vivo tumor xenograft model. Animals were randomly assigned to three groups: SPS treatment, cisplatin treatment, and the model group (no treatment). The body weight, tumor volume, and tumor weight were measured, and the expression of the above molecules was determined.ResultsSPS treatment (0.02–0.64 mg/mL) for 24–72 h inhibited HN-6 cell proliferation. In addition, 0.64 mg/mL SFP markedly induced apoptosis in HN-6 cells and arrested the cell cycle at the G0/G1 phase. Compared with the control group, the expression of Bcl-2 and COX-2 was markedly reduced by SPS treatment, whereas the expression of Bax and cleaved caspase-3 was increased. Moreover, SPS significantly inhibited the growth of the tumor xenograft, with similar changes in the expression of Bcl-2, COX-2, Bax, and cleaved caspase-3 in the tumor xenograft to the in vitro analysis.ConclusionsOur results indicated that SPS may inhibit TSCC development through regulation of Bcl-2, COX-2, Bax, and cleaved caspase-3 expression.

show abstract

The Value of Safflower Yellow Injection for the Treatment of Acute Cerebral Infarction: A Randomized Controlled Trial

Cited by 13 publications

References 16 publications

Exploring and applying the substrate promiscuity of a C-glycosyltransferase in the chemo-enzymatic synthesis of bioactive C-glycosides

Exploring and applying the substrate promiscuity of a C-glycosyltransferase in the chemo-enzymatic synthesis of bioactive C-glycosides

Effects of Safflower Yellow on the Treatment of Severe Sepsis and Septic Shock: A Randomized Controlled Clinical Trial

Safflower polysaccharide inhibits the development of tongue squamous cell carcinoma

Contact Info

Product

Resources

About