The value of shear wave elastography in the quantification of corpus cavernosum penis rigidity and its alteration with age

İnci, Ercan; Türkay, Rüştü; Nalbant, Mustafa Orhan; Yenice, Mustafa Gürkan; Tuğcu, Volkan

doi:10.1016/j.ejrad.2017.01.029

Cited by 28 publications

(26 citation statements)

References 15 publications

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“…In previous studies, we tested two-dimensional shear-wave elastography (2-D SWE, ShearWave™ Elastography) for the detection of penile CC tissue stiffness, and found that the obtained values were correlated with age and serum testosterone levels in male volunteers aged from 19 to 81 years old 7. These findings were supported by a recent study by Inci et al ,8 and 2-D SWE showed future potential for evaluating penile CC lesions. Two-dimensional SWE is a new quantitative ultrasound technology that makes the target tissue generate transverse shear waves by ultrasonic pulses.…”

Section: Introductionsupporting

confidence: 72%

Novel noninvasive quantification of penile corpus cavernosum lesions in hyperlipidemia-induced erectile dysfunction in rabbits by two-dimensional shear-wave elastography

Chen

et al. 2019

Asian J Androl

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Structural alterations in fibroelastic components of the penile corpus cavernousum (CC) may impair its compliance, resulting in venous leakage and erectile dysfunction (ED). Our study evaluated the effectiveness of noninvasive two-dimensional shear-wave elastography (2-D SWE) in quantifying penile CC lesions in rabbits with hyperlipidemia-induced ED. A total of 12 New Zealand white rabbits were randomly divided into two groups. Six were fed a high-cholesterol diet containing 2% cholesterol and 8.5% lard for 10 weeks and the other six were fed normal diet as controls. We measured the shear-wave elastic quantitative (SWQ) value of penile CC by 2-D SWE. Erectile function was investigated by intracavernous injection of papaverine, and immunohistochemical (IHC) staining and the western blot analysis to determine the penile CC lesions. After 10 weeks, the SWQ values obtained from penile CC were remarkably higher in the high-cholesterol-fed compared with the control group, and the ΔICP (ICP plateau minus ICP baseline)/MAP (ICP: intracavernous pressure, MAP: mean arterial pressure) was markedly decreased. The IHC staining and western blot revealed extracellular matrix (ECM) accumulation in penile cavernous tissues, and the smooth muscle cell (SMC) phenotypic transition was affected, as indicated by reduced alpha-smooth muscle actin and calponin-1 expression and increased phospho-myosin light chain20 (p-MLC20)/MLC20 and osteopontin expression. Hyperlipidemia resulted in ECM accumulation accompanied with SMC phenotypic transition in penile CC and impaired the erectile function eventually. These might, in turn, lead to variations in the SWQ values. It suggests that 2-D SWE may be a novel, noninvasive and effective approach that distinguishes penile CC lesions secondary to hyperlipidemia from normal.

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Section: Introductionsupporting

confidence: 72%

Novel noninvasive quantification of penile corpus cavernosum lesions in hyperlipidemia-induced erectile dysfunction in rabbits by two-dimensional shear-wave elastography

Chen

et al. 2019

Asian J Androl

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“…In a study conducted by Inci et al . the authors drew similar conclusions [44]. Some studies, using sonoelastography on Peyronie’s plaques, reported that sonoelastography provided additional and useful information in detecting penile lesions [42,43].…”

Section: Discussionmentioning

confidence: 64%

“…There are some studies in the literature using elastography, including real-time strain sonoelastography or shear wave elastography (SWE), on penile structure and penile mass, such as Peyronie’s plaques [22,42-44]. Stiffness of the penile cavernous body reflects the changes in tissue structure and composition of corpus cavernosum penis, which includes decreased sinusoids, and this results in occlusion and fibrosis [3,22].…”

Section: Discussionmentioning

confidence: 99%

Penile Doppler ultrasonography and elastography evaluation in patients with erectile dysfunction

Altınbaş

Hamidi²

2018

Pol J Radiol

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PurposeTo evaluate the relationship between erection grade, erectile function score, Doppler ultrasonography (US) indexes, and elasticity score (ES) according to Doppler US diagnosis in patients with erectile dysfunction (ED).Material and methodsReal-time strain type penile elastography was performed during penile Doppler US examination for 88 patients with ED. The diagnosis according to Doppler US was determined. Erection score according to the Erection Hardness Grading Scale was evaluated. A scoring for erectile function was performed with the International Index of Erectile Function (IIEF-5), and the Sexual Health Inventory for Men (SHIM) was defined. The relationships, according to Doppler diagnosis, of ES, IIEF-5 score, SHIM scale, and erection score were evaluated.ResultsAmong the patients, 50 (57%) had abnormal penile Doppler US findings. According to Doppler US findings, patients were classified as normal (n = 38), borderline for arterial insufficiency (n = 4), arterial insufficiency (n = 5), and venous insufficiency (n = 41). The lowest erection hardness grades and IIEF-5 scores were detected in patients with arterial failure. When compared to the normal group, in terms of ES, the arterial failure borderline group and venous failure group had lower scores, and the arterial failure group had a higher score. However, the only significant difference was obtained in the left cavernous body of the venous failure group.ConclusionsSonoelastography seems to add additional value for determination of stiffness of the penile cavernous body in routine evaluation of ED.

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“…Actually, erectile function strongly depends on the structure of corpus cavernosum (CC) penis besides the vascular and neuronal supply (Inci et al., 2017). Smooth muscle cells and collagen are the main functional density of CCP.…”

Section: Discussionmentioning

confidence: 99%

“…Inci et al. (2017) showed that SWE can provide valuable information as a noninvasive quantitative imaging modality to assess penile structure. In a cohort of 37 healthy subjects, the author also found that the SWE value decreased significantly from Grade 0 to Grade 4 of the erectile hardness (Zheng et al., 2012).…”

Section: Discussionmentioning

confidence: 99%

Role of shear wave elastography measured in the flaccid state in predicting arteriogenic erectile dysfunction

Zhang

Wang

et al. 2021

Andrologia

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The gold‐standard method for diagnosing arteriogenic erectile dysfunction (AED) is the penile Doppler ultrasonography. We proposed a novel method for predicting AED using ultrasonic shear wave elastography (SWE) considering that the former was invasive and variable. A total of 98 male patients were enrolled in our study, referred for ED between December 2018 and October 2020. For comparison, we also included 42 volunteers from the Healthy Physical Examination Center of our hospital. The Penile Doppler Ultrasonography (PDU) and SWE were performed for all patients with the intracavernosal injection (ICI). We named three groups as AED group, nonvascular ED group and healthy controls group. No statistically significant differences were found among the three groups in terms of demographic and clinical characteristics. There were no significant differences in IIEF‐5 between AED and nonvascular ED. A significant (r = 0.642, p < 0.0001) positive correlation between flaccid and erectile SWE was observed. With a cut‐off value of 13.45 KPa, the area under curve, specificity, and sensitivity of the SWE values under the flaccid state in distinguishing AED from healthy subjects were 0.867, 0.786 and 0.896 respectively. The SWE value in the flaccid state can distinguish the AED from healthy subjects.

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The value of shear wave elastography in the quantification of corpus cavernosum penis rigidity and its alteration with age

Cited by 28 publications

References 15 publications

Novel noninvasive quantification of penile corpus cavernosum lesions in hyperlipidemia-induced erectile dysfunction in rabbits by two-dimensional shear-wave elastography

Novel noninvasive quantification of penile corpus cavernosum lesions in hyperlipidemia-induced erectile dysfunction in rabbits by two-dimensional shear-wave elastography

Penile Doppler ultrasonography and elastography evaluation in patients with erectile dysfunction

Role of shear wave elastography measured in the flaccid state in predicting arteriogenic erectile dysfunction

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