The Value of the Effect of the Level of Specific Antibodeis on Elimination Different Tick-Borne Encephalitis Virus Strains

Леонова, Г. Н.; Lubova, V. A.; Калинин, А. В.

doi:10.31631/2073-3046-2017-16-2-50-54

Cited by 5 publications

(3 citation statements)

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“…Чтобы принять правильное решение о сроках ревакцинации, первоначально можно рекомендовать исследование крови на напряженность иммунитета к вирусу КЭ. Исходя из данных, полученных ранее [6,22], а также данных настоящего исследования, мы пришли к выводу о том, что быстрая элиминация вируса (спустя 1-2 суток) может происходить у вакцинированных лиц с антителами в титрах 1:400 и более. Лицам с антителами в сыворотке крови в титрах 1:100 и 1:200, видимо, следует предлагать обязательное проведение ревакцинации.…”

Section: Discussionunclassified

“…В то же время у некоторых людей после курса первичной вакцинации могут вырабатываться антитела с высокими титрами, которые сохраняются долго [4,20]. В ранее опубликованных работах [6,20,22] нами были определены уровни иммунологической памяти (1:100) и защитного титра (1:400) специфических антител при действии эпидемически значимой заражающей дозы вируса КЭ, равной 3,0 log ТЦД 50 /мл. Мы посчитали, что такой уровень специфических антител способен защитить пациентов на ранних стадиях инфицированности сразу после укуса клеща, содержащего вирус КЭ.…”

Section: рисунок 4 динамика проявления инфекционных свойств не нейтрunclassified

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Comprehensive assessment of specific antibodies on infectious activity of tick-borne encephalitis virus

Леонова¹,

Майстровская²,

Lubova³

et al. 2019

Russian Journal of Infection and Immunity

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Vaccines for prophylactic immunization provide the most reliable and effective protection against the vast majority of infectious diseases. Tick-borne encephalitis (TBE) represents a high-priority medical issue at the territory of the Eurasian continent. Of great importance is assessing a role of distinct antibody titers especially low titers, observed quite often in vaccinated individuals, sometimes posing obstacles in determining a threshold of seropositivity as well as the level of specific protection against TBE virus. We aimed at obtaining data to assess antiviral activity of virus-specific antibodies with distinct titer levels based on the in vitro, ex vivo and in vivo experimental studies with a highly virulent Far-Eastern strain of tick-borne encephalitis virus. The in vitro, ex vivo and in vivo comprehensive experimental studies with a highly virulent Far-Eastern strain of tick-borne encephalitis virus (TBEV) were conducted and the dynamics of antiviral activity of virus-specific antibodies at variable titers (1:100–1:3200) was measured (timeframe ranged within 1–96 hours p.i.) to provide a rationale for evaluating the antiviral immune response. It was found that the in vitro experiments demonstrated that the IgG at 1:100 titer exerted a weak anti-TBEV neutralizing effect at all time-points examined. The IgG 1:400 titer caused a 2 log PFU/mL decline in TBEV Dal strain yield at 72 h post-infection, whereas at 1:3200 titer it completely suppressed TBEV replication throughout the observation period. The ex vivo experiments with blood serum obtained from vaccinated subjects demonstrating a range of TBEV antibody titers (sera from vaccinated individuals with varying anti-TBEV antibody titers) and in vivo (outinbred white mice) experiments revealed a delayed virus elimination for antibody titers at 1:100 and 1:200 as well as rapid virus elimination (1–2 days p.i.) for antibody titers greater than 1:400. Thus, antibody titer at 1:400 may be considered as the universal anti-TBEV protection threshold. In order to properly conclude regarding the revaccination schedule it is advised to start with testing blood serum for durability of anti-TBEV immune response. Subjects with TBEV antibody titers at 1:100 and 1:200 should be strongly recommended to undergo a mandatory revaccination. Such an approach is believed to be the most effective way toward enhancing efficacy of vaccine-mediated protection against TBE.

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Section: Discussionunclassified

Section: рисунок 4 динамика проявления инфекционных свойств не нейтрunclassified

Comprehensive assessment of specific antibodies on infectious activity of tick-borne encephalitis virus

Леонова¹,

Майстровская²,

Lubova³

et al. 2019

Russian Journal of Infection and Immunity

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“…У 16 из 120 (13,3 ± 3,10 %) титр антител составил 1 : 400, и его, согласно исследованиям Г.Н. Леоновой (2017), нельзя с уверенностью считать защитным [16,17]. У 66 человек из 120 серопозитивных (55,0 ± 4,54 %) титры антител составили 1 : 800 и выше, что обеспечивает защиту от возбудителя КВЭ в случае присасывания клеща.…”

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The Study of Community Immunity to the Tick-Borne Encephalitis Virus in One of the Non-Endemic Areas of the Khabarovsk Krai (the Tuguro-Chumikansky District)

Romanova¹,

Dragomeretskaya²,

Троценко³

et al. 2020

PH&LE

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Introduction. At present, the areas endemic for tick-borne encephalitis (TBE) tend to expand. Monitoring of TBEV antibody detection rates in the population of non-endemic areas in order to adopt timely measures for specific and non-specific disease prevention thus acquires particular importance. The Tuguro-Chumikansky District is not among the endemic areas of the Khabarovsk Krai. Yet, the rise in the number of people seeking medical attention for an ixodes tick bite and TBE rates in the local population has been registered recently. Our purpose was to establish the level of natural herd immunity to the tick-borne encephalitis virus in the population of the Tuguro-Chumikansky District. Materials and methods. We conducted a serological survey among unvaccinated permanent residents of 6 villages of the study district. Results. The highest TBEV antibody detection rates were registered in the examined residents of the villages of Tugur (61.3 ± 8.75%) and Udskoye (51.4 ± 8.22%). On the whole, specific immunoglobulins for the tick-borne encephalitis virus were found in 29.4 ± 2.26% of the subjects, thus indicating that the locals have contacts with infected vectors or have possibly suffered from the inapparent (subclinical) infection. Discussion. The established immunoglobulin G detection rates and immunity levels to TBEV may show that the population of the Tuguro-Chumikansky District is involved in the epidemic process. A further increase in the number of people bitten by ticks can lead to an increase in the registered TBE incidence in the district making it yet another regional area endemic for the disease.

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Effectiveness of Specific Prevention of Tick-Borne Encephalitis

Щербинина¹,

Бархалева²,

Дорохова³

et al. 2020

Biopreparaty. Profilaktika, diagnostika, lechenie

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Vaccination remains the only way to prevent tick-borne encephalitis (TBE). All TBE vaccines are based on strains of the Far Eastern and European subtypes of TBE virus. Currently, the Siberian subtype of the virus, which differs from the vaccine strains, accounts for 80–100% of the genetic population of TBE virus in most of Russia. The proportion of TBE vaccinated patients among those infected was different from year to year in Russia, e.g. 3.9% in 2012 and 1.5% in 2018, there were also some fatal cases registered among vaccinated patients. In this regard, evaluation of the effectiveness of vaccination against various genetic subtypes of TBE is a promising area of research. The purpose of this study was to summarise the results of studies investigating effectiveness of specific prevention of TBE as regards various genetic subtypes of the virus. The paper analyses data on the effectiveness of TBE vaccination in experimental settings and in real life. It was demonstrated that the use of vaccines for prevention of TBE is effective, provided the vaccination coverage is not less than 80%. The paper cites the data from a long-term study of the stability and protective activity of vaccine immunity against TBE virus strains isolated in highly endemic territories. It was established that TBE vaccines have high immunogenic activity and contribute to the production of stable protective antibodies against the strains of the three genetic subtypes of the virus. Protective efficacy of vaccination depends on the number of vaccinations received, the vaccination scheme, gender and age of those vaccinated. The paper concludes by saying that further studies are needed to assess TBE vaccine efficacy in order to improve vaccination tactics, to better understand causes of morbidity and mortality among vaccinated individuals.

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The Value of the Effect of the Level of Specific Antibodeis on Elimination Different Tick-Borne Encephalitis Virus Strains

Cited by 5 publications

References 5 publications

Comprehensive assessment of specific antibodies on infectious activity of tick-borne encephalitis virus

Comprehensive assessment of specific antibodies on infectious activity of tick-borne encephalitis virus

The Study of Community Immunity to the Tick-Borne Encephalitis Virus in One of the Non-Endemic Areas of the Khabarovsk Krai (the Tuguro-Chumikansky District)

Effectiveness of Specific Prevention of Tick-Borne Encephalitis

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