The values of mean platelet volume and the mean platelet volume/platelet ratio for predicting deep venous thrombosis in Behçet’s disease

Erden, Fatma; Karagöz, Hatice; Avcı, Atıl; Avci, Deniz; Çetinkaya, Ali; Erden, Abdülsamet

doi:10.1515/labmed-2017-0068

Cited by 7 publications

(12 citation statements)

References 24 publications

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“…In some studies, MPVPR levels have been found to be higher in various patients who had inflammatory process like sepsis and pancreatitis. Additionally, increased thrombosis and mortality were reported in Behçet disease [44][45][46]. Among the English literature on the MPVPCR in COVID-19, the current study is unique with its findings.…”

Section: Discussionmentioning

confidence: 70%

Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?

Şan¹,

Gemcioğlu²,

Davutoğlu³

et al. 2021

Turk J Med Sci

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IntroductionCoronavirus 2019 disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a pandemic infectious disease that causes morbidity and mortality. To date there are no proven diagnostic or prognostic parameters, but clinicians can use predictive parameters, such as the leukocyte and lymphocyte counts, C-reactive protein (CRP), D-dimer, and ferritin levels, and radiological imaging [1-3]. In the inflammation process of COVID-19, CRP, platelet, ferritin, and leukocyte values may increase, while albumin and lymphocyte values may decrease [4][5][6].White blood cells (WBCs), including neutrophils, lymphocytes, monocytes, have been used as inflammatory Background/aim: Coronavirus 2019 disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a pandemic infectious disease that causes morbidity and mortality. As a result of high mortality rate among the severe COVID-19 patients, the early detection of the disease stage and early effective interventions are very important in reducing mortality. Hence, it is important to differentiate severe and nonsevere cases from each other. To date, there are no proven diagnostic or prognostic parameters that can be used in this manner. Due to the expensive and not easily accessible tests that are performed for COVID-19, researchers are investigating some parameters that can be easily used. In some recent studies, hematological parameters have been evaluated to see if they can be used as predictive parameters. Materials and methods:In the current study, almost all hematological parameters were used, including the neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, monocyte/lymphocyte ratio, mean platelet volume to lymphocyte ratio, mean platelet volume to platelet ratio, plateletcrit, and D-dimer/fibrinogen ratio, neutrophil/lymphocyte/platelet scoring system, and systemic immune-inflammation index. A total of 750 patients, who were admitted to Ankara City Hospital due to COVID-19, were evaluated in this study. The patients were classified into 2 groups according to their diagnosis (confirmed or probable) and into 2 groups according to the stage of the disease (nonsevere or severe). Results:The values of the combinations of inflammatory markers and other hematological parameters in all of the patients with severe COVID-19 were calculated, and the predicted values of these parameters were compared. According to results of the study, nearly all of the hematological parameters could be used as potential diagnostic biomarkers for subsequent analysis, because the area under the curve (AUC) was higher than 0.50, especially for the DFR and NLR, which had the highest AUC among the parameters. Conclusion:Our findings indicate that, the parameters those enhanced from complete blood count, which is a simple laboratory test, can help to identify and classify COVID-19 patients into non-severe to severe groups.

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Section: Discussionmentioning

confidence: 70%

Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?

Şan¹,

Gemcioğlu²,

Davutoğlu³

et al. 2021

Turk J Med Sci

Self Cite

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“…Eventually, 10 articles with 1513 VTE participants and 2593 control participants were included for quantitative synthesis. 17–26…”

Section: Resultsmentioning

confidence: 99%

“…A majority of studies were conducted in Turkey. 17, 19–21, 23, 26 Among the included literature, PE, 17, 20 DVT 21, 23–26 and VTE 18, 19, 22 were 2, 5, and 3, respectively. The cut-off value of NLR vary widely ranging from 1.76 to 5.3.…”

Section: Resultsmentioning

confidence: 99%

The Association of Neutrophil–Lymphocyte Ratio with Venous Thromboembolism: A Systematic Review and Meta-Analysis

Cai

Zhou

2022

Clin Appl Thromb Hemost

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The neutrophil–lymphocyte ratio(NLR) has been used for diagnosing venous thromboembolism (VTE). We aimed to assess the accuracy of NLR to diagnose VTE by meta-analysis. Systematic electronic searches were conducted June 2, 2021 in PubMed, Embase(Ovid), and Cochrane Library. The search did not have any language or time restriction applied. Our search strategy was based on keywords in combination with both medical subject headings (MeSH) terms and text words. The diagnostic odds ratio, summary receiver operating characteristics, sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio were estimated. 10 articles with 1513 VTE participants and 2593 control participants were included for quantitative synthesis. The pooled values were as follows: sensitivity = 0.68(95% CI 0.45-0.84), specificity = 0.73(95% CI 0.6-0.83), positive likelihood ratio = 2.5(95% CI 1.8-3.4), negative likelihood ratio = 0.44(95% CI 0.26-0.75), diagnostic odds ratio = 6(95% CI 3-11), and SROC = 0.76(95% CI: 0.73-0.8). NLR could be diagnostic factor for the detection of potential VTE, the accuracy thereof in the current meta-analysis exhibited moderate accuracy for diagnosing VTE. Furthermore, further large cohort studies are needed to determine optimal cut-off values of NLR.

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“…MPV is now well known as a predictor of inflammation and has been shown in many cases as a marker of inflammation [17] [18] [19]. In our previous research, we have shown that we can use MPV in the diagnosis of uveitis and venous thrombosis in patients with Behçet's syndrome [20] [21].…”

Section: Introductionmentioning

confidence: 89%

Dipeptidyl Peptidase-4 Inhibitors and Inflammation: Dpp-4 Inhibitors Improve Mean Pleatelet Volume and Gamma Glutamyl Transferase Level

Avcı¹

2019

JBM

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AIM: The purpose of this research was to determine the changes of the inflammatory parameters in the long term with the use of dipeptidyl peptidase-4 inhibitors. Material and Methods: In this research we have retrospectively reviewed the records of 80 patients who had added dipeptidyl peptidase-4 inhibitors (40 sitagliptin and 40 vildagliptin) to their ongoing therapies. Patients' values of inflammation at the beginning of this process were taken as initial values, while values at the end of this process were considered as final values. Results: A total of 80 patients [38.8% (n = 31) of the patients were male, while 61.3% (n = 49) were female] enrolled in the study. When the whole group was evaluated, the mean age was 56.1 ± 9.7 years. The median follow-up time of the patients with DPP-4 inhibitors was 18 (2-64) months. The mean MPV value was measured as 8.79 ± 1.71 fL before DPP-4 inhibitors and it was 10.06 ± 1.42 fL after the follow-up period (p < 0.001). The median value serum GGT was 30.5 (13-194) U/L before DPP-4 inhibitor and 29.5 (12-112) U/L at the end (p = 0.048). The mean uric acid level before the use of dipeptidyl peptidase-4 inhibitors was 4.7 ± 1.6 mg/dL, and this level was 5.0 ± 1.5 mg/dL after the follow-up period (p = 0.048). Conclusion: In this study, it was observed that MPV and GGT levels were improved by dipeptidyl peptidase-4 inhibitors in long-term.

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The values of mean platelet volume and the mean platelet volume/platelet ratio for predicting deep venous thrombosis in Behçet’s disease

Cited by 7 publications

References 24 publications

Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?

Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?

The Association of Neutrophil–Lymphocyte Ratio with Venous Thromboembolism: A Systematic Review and Meta-Analysis

Dipeptidyl Peptidase-4 Inhibitors and Inflammation: Dpp-4 Inhibitors Improve Mean Pleatelet Volume and Gamma Glutamyl Transferase Level

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