IT is well known to dairymen that the amount of milk that a cow gives during an individual lactation is not uniform, month by month, but changes in a rather characteristic way. Moreover, the course of milk production varies from one lactation to another of a single cow and also differs from cow to cow. In her succeeding lactations, a cow tends to have a higher total milk production (20,31). This relation has been studied in considerable detail by many authors, but some of the consequences of the change of milk production with time during a single lactation are not so well known. A cow's milk yield usually starts vigorously and gradually diminishes as the lactation is prolonged. It is the purpose of this paper to study this time change during a single lactation in some detail. The data are quite comprehensive and furnish information on several points which are of considerable biological interest.First, the form of these time changes of milk production during an individual lactation is studied. This trend may be adequately described solely in terms of the initial yield and the rate of decline. The mathematical constants representing these two factors for each lactation are then studied in relation to certain general and biological conditions.The calendar year and the month in which a lactation began are the general environmental facts which are studied in respect to the constants of the individual time-change curves.Of the many biological problems connected with milk production, this paper is concerned with the relation of the constants of these timechange curves to the length of time the cow was pregnant during a given lactation; the age of the cow at the beginning of the lactation; the length 1 Paper No. 198 from the