The vascular pattern of basal cell tumors: Light microscopy and scanning electron microscopic study on vascular corrosion casts

Grunt, Thomas W.; Lametschwandtner, Alois; Staindl, O.

doi:10.1016/0026-2862(85)90026-3

Cited by 58 publications

(32 citation statements)

References 18 publications

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“…In an attempt to overcome the deficiencies of the existing vasculature and stimulate their own growth, tumors induce the expression of proangiogenic factors to increase their blood supply [3,4]. The induction of angiogenesis by the tumor results in convoluted, irregular vasculature [5][6][7]. These newly formed blood vessels are highly twisted, tortuous with blind ends and arterio-venous shunts.…”

Section: Introductionmentioning

confidence: 99%

Hypoxia, gene expression, and metastasis

Chan

Giaccia

2007

Cancer Metastasis Rev

270

210

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Hypoxia poses many problems to the treatment of cancer. Hypoxic tumors are more resistant to chemotherapy and radiation. In addition, hypoxia induces a number of genes responsible for increased invasion, aggressiveness, and metastasis of tumors. The augmented metastatic potential due to hypoxia-mediated gene expression is discussed in this section. Particular attention is given to recent studies of specific genes involved in the key steps of metastasis, including extracellular matrix interactions, migration, and proliferation.

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Section: Introductionmentioning

confidence: 99%

Hypoxia, gene expression, and metastasis

Chan

Giaccia

2007

Cancer Metastasis Rev

270

210

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“…Indeed, BCCs have been shown to utilize a specialized tumor-associated microvasculature for growth [2]. BCCs contain a basket-like capillary plexus interwoven throughout the tumor bed, with many abnormal blood vessels with luminal diameters of 20 mm and greater [3]. By specifically targeting the tumor vasculature, BCC tumor burden may be decreased or even eliminated with less damage to the surrounding skin structures.…”

Section: Introductionmentioning

confidence: 99%

The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas

Shah

Konnikov²,

Duncan

et al. 2009

Lasers Surg Med

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Background and Objective: Basal cell carcinomas (BCCs) have supporting vasculature that could serve as a target for 595 nm pulsed dye laser (PDL). The objective of this study was to determine the effect of repeated PDL treatments on BCCs of superficial and nodular subtypes and of varying diameters. Study Design/Materials and Methods: Twenty biopsyproven BCCs received four 595 nm PDL treatments at 2-week intervals. The tumor and 4 mm of peripheral skin were treated using a set of previously optimized laser parameters: one pass, 15 J/cm 2 energy, 3 ms pulse length, no cooling, and 7 mm spot size with 10% overlap. The treated area was excised and evaluated histologically for residual tumor. Histologic response rates of the PDL treated BCCs were compared with that of non-PDL treated, matched control tumors. Results: Nearly all BCCs <1.5 cm in diameter (n ¼ 12) showed complete response to four PDL treatments (91.7%; n ¼ 11/12) versus 16.7% of controls (n ¼ 2/12, P-value ¼ 0.0003). BCCs !1.5 cm in diameter (n ¼ 8) showed a complete response rate of 25% (n ¼ 2/8) versus 0% of controls (n ¼ 0/8, P-value ¼ 0.2). Mean clinical tumor diameter of the complete responders was 1.1 cm (n ¼ 13) versus 2.2 cm (n ¼ 7) for incomplete responders (P-value ¼ 0.005). Tumor histologic types among the complete responders included superficial, nodular, micronodular, and keratinizing. Incompletely responding BCCs showed a significant reduction in tumor burden after PDL treatment, with residual histologic tumor burden ranging from <1% to 29% of the original clinical tumor diameter, compared to 13-68% residual tumor burden for the corresponding controls (P-value ¼ 0.05). Conclusions: PDL is an effective means of reducing tumor burden in patients with large BCCs and may be an alternative therapy in BCCs <1.5 cm in diameter.

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“…31 Moreover, as a result of hypoxia-mediated angiogenesis, tumors undergo neovascularization, allowing for the development of new blood vessels to support lesion expansion; however, unlike normal blood vessels, tumor vasculature often consists of malformed, tortuous, leaky blood vessels that are prone to occlusion and reversal of blood flow. [32][33][34] Closed vessels can then intermittently Figure 1. Hypoxia-mediated erk signaling and Bim suppression is maintained after reoxygenation in suspended cells and 3D culture.…”

Section: Hypoxia-mediated Erk Signaling/ Bim Suppression Is Maintainementioning

confidence: 99%

Surviving without oxygen: Hypoxia regulation of mammary morphogenesis and anoikis

Whelan

Reginato²

2011

Cell Cycle

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The vascular pattern of basal cell tumors: Light microscopy and scanning electron microscopic study on vascular corrosion casts

Cited by 58 publications

References 18 publications

Hypoxia, gene expression, and metastasis

Hypoxia, gene expression, and metastasis

The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas

Surviving without oxygen: Hypoxia regulation of mammary morphogenesis and anoikis

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