The vasodilating action of various therapeutic procedures which are used in the treatment of peripheral vascular disease

Abramson, David I.; Zazeela, Herman; Schkloven, Norman

doi:10.1016/s0002-8703(41)90803-7

Cited by 27 publications

(3 citation statements)

References 32 publications

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“…Treatment of Intermiftent Claudication with "Padutin" Werle and Multhaupt (1937) found that the injection of padutin, an insulin-free pancreatic extract, caused an Abramson et al (1941) found no change in the resting blood flow to the hand, leg, or forearm after the intramuscular injection of four biological units. Allen et al (1946) state that the exact mechanism of relief of the pain of claudicatio'n by tissue extracts is not well understood, but that the extract seems to prevent in some way the chemical changes which produce pain in exercised ischaemic muscles.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Treatment in Intermittent Claudication

Shepherd¹

1950

BMJ

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Section: Resultsmentioning

confidence: 99%

Evaluation of Treatment in Intermittent Claudication

Shepherd¹

1950

BMJ

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“…There have been very few quantitative measurements reported of its effects on peripheral blood-flow in normal subjects, however (Abramson et al, 1941), and none in subjects with ischaemic legs, though intra-arterial alcohol therapy has been described (Edwards et al, 1952;Conrad and Green, 1964). The present paper gives the results of measurements undertaken to establish quantitatively the nature of the vasodilatation produced by alcohol, with particular reference to the effect of whisky on blood-flow in the legs both of healthy subjects and of those with occlusive peripheral arterial disease.…”

Section: Discussionmentioning

confidence: 99%

Vasodilator properties of alcohol.

Gillespie¹

1967

BMJ

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Acute Gouty Arthritis-Emmerson MEIcAlJou.N and more rapid relief of pain than the lower dose range, as 18 out of 22 patients obtained relief within the first four hours, a matter of importance in such a painful condition. The decisive factor would seem to be the severity of the gouty arthritis.Boardman and Hart (1965) reported no response to indomethacin in four females with gout, but the two females in the group under study responded in a manner quite indistinguishable from that of the males-again the difference in response may be one of dosage. It would seem that the higher the dosage used the more rapid the response and the greater the proportion of patients responding. The factors limiting dosage then become the cost and the incidence of side-effects.Reports of the use of indomethacin in other joint diseases Smyth, 1965) have included a high incidence of headache, giddiness, nausea, or vomiting. The incidence seemed to depend largely upon the daily dose of indomethacin administered, ranging from 30 to 80% with daily doses of 100 to 200 mg. This trial has therefore been unusual for the low incidence of side-effects found. Boardman and , using doses which sometimes reached 600 mg. daily, found a 30% incidence of side-effects in their gouty patients ; they also commented that these were not severe. Their lower dosage was therefore not associated with any reduction in the incidence of side-effects, though they thought that sideeffects were less severe in younger patients. It seems possible that patients with acute gout, who are relatively young and otherwise healthy, may be more tolerant of the side-effects of indomethacin than patients suffering from a chronic debilitating disease such as rheumatoid arthritis. SummaryThe results of treatment with a regimen of indomethacin therapy in 22 patients with acute gouty arthritis are described. The regimen consisted in administering 100 mg. of irndomethacin by mouth four-hourly until most of the pain was relieved, after which administration was continued at eighthourly intervals with three doses of 100 mg., three of 75 mg.,, and three of 50 mg. This method has been shown to be very effective in producing rapid relief of pain and subsidence of the acute gouty arthritis and to be associated with a low incidence of side-effects. The facial flushing associated with the consumption of alcohol is a well-recognized phenomenon, and alcohol, often in the form of whisky, has been widely recommended as a useful peripheral vasodilator agent. There have been very few quantitative measurements reported of its effects on peripheral blood-flow in normal subjects, however (Abramson et al., 1941), and none in subjects with ischaemic legs, though intra-arterial alcohol therapy has been described (Edwards et al., 1952;Conrad and Green, 1964). The present paper gives the results of measurements undertaken to establish quantitatively the nature of the vasodilatation produced by alcohol, with particular reference to the effect of whisky on blood-flow in the legs both of healthy subjects...

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“…Alcohol approximately doubles the circulation in the hand by causing vasodilatation of cutaneous arterioles (ABRAMSON et al 1941). Alcohol approximately doubles the circulation in the hand by causing vasodilatation of cutaneous arterioles (ABRAMSON et al 1941).…”

Section: A) Drugs Acting On Higher Centresmentioning

confidence: 99%