The vasopressin−memory hypothesis: a citation network analysis of a debate

Leng, Gareth; Leng, Rhodri; Maclean, Stewart

doi:10.1111/nyas.14110

Cited by 9 publications

(8 citation statements)

References 103 publications

(118 reference statements)

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“…Oxytocin (OT) and vasopressin (VP) are important factors for both peripheral physiological functions, and the central regulation of a variety of behaviours . OT and VP modulate several behaviours important for the survival and propagation of species, including parental behaviour, reproduction and behaviours important for other social interactions .…”

Section: Introductionmentioning

confidence: 99%

Comparison of the distribution of oxytocin and vasopressin 1a receptors in rodents reveals conserved and derived patterns of nonapeptide evolution

Freeman

Aulino

Caldwell

et al. 2020

J Neuroendocrinology

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| INTRODUC TI ONOxytocin (OT) and vasopressin (VP) are important factors for both peripheral physiological functions, 1-6 and the central regulation of a variety of behaviours. [7][8][9][10][11] OT and VP modulate several behaviours important for the survival and propagation of species, including parental behaviour, 12-14 reproduction 15-18 and behaviours important for other social interactions. 19,20 These peptides (and their non-mammalian homologues; hereafter referred to as OT and VP for simplicity) have been found to influence social behaviour in one form AbstractOxytocin (OT) and vasopressin (VP) are known modulators of social behaviour across rodents. Research has revealed the location of action of these nonapeptides through localization of their associated receptors, which include the oxytocin receptor (OTR) and the vasopressin 1a receptor (V1aR). As research into these complex systems has progressed, studies investigating how these systems modulate behaviour have remained relatively narrow in scope (ie, focused on how a single brain region shapes behaviour in only a handful of species). However, the brain regions that regulate social behaviour are part of interconnected neural networks for which coordinated activity enables behavioural variation. Thus, to better understand how nonapeptide systems have evolved under different selective pressures among rodent species, we conducted a meta-analysis using a multivariate comparative method to examine the patterns of OTR and V1aR density expression in this taxon. Several brain regions were highly correlated based on their OTR and V1aR binding patterns across species, supporting the notion that the distribution of these receptors is highly conserved in rodents. However, our results also revealed that specific patterns of V1aR density differed from OTR density, and within-genus variance for V1aR was low compared to between-genus variance, suggesting that these systems have responded and evolved quite differently to selective pressures over evolutionary time. We propose that, in addition to examining single brain regions of interest, taking a broad comparative approach when studying the OT and VP systems is important for understanding how the systemic action of nonapeptides modulate social behaviour across species. K E Y W O R D S evolutionary plasticity, receptor autoradiography, Rodentia, social behaviour network S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Freeman AR, Aulino EA, Caldwell HK, Ophir AG. Comparison of the distribution of oxytocin and vasopressin 1a receptors in rodents reveals conserved and derived patterns of nonapeptide evolution. J Neuroendocrinol.

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Section: Introductionmentioning

confidence: 99%

Comparison of the distribution of oxytocin and vasopressin 1a receptors in rodents reveals conserved and derived patterns of nonapeptide evolution

Freeman

Aulino

Caldwell

et al. 2020

J Neuroendocrinology

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“…Section planes were standardized according to the atlas of Paxinos and Watson [92]. Images were taken with a digital camera coupled to a bright-field microscope (Olympus BX51), with no further modifications.…”

Section: C-fosmentioning

confidence: 99%

Rescue of Vasopressin Synthesis in Magnocellular Neurons of the Supraoptic Nucleus Normalises Acute Stress-Induced Adrenocorticotropin Secretion and Unmasks an Effect on Social Behaviour in Male Vasopressin-Deficient Brattleboro Rats

Török

Csikota

Fodor

et al. 2022

IJMS

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The relevance of vasopressin (AVP) of magnocellular origin to the regulation of the endocrine stress axis and related behaviour is still under discussion. We aimed to obtain deeper insight into this process. To rescue magnocellular AVP synthesis, a vasopressin-containing adeno-associated virus vector (AVP-AAV) was injected into the supraoptic nucleus (SON) of AVP-deficient Brattleboro rats (di/di). We compared +/+, di/di, and AVP-AAV treated di/di male rats. The AVP-AAV treatment rescued the AVP synthesis in the SON both morphologically and functionally. It also rescued the peak of adrenocorticotropin release triggered by immune and metabolic challenges without affecting corticosterone levels. The elevated corticotropin-releasing hormone receptor 1 mRNA levels in the anterior pituitary of di/di-rats were diminished by the AVP-AAV-treatment. The altered c-Fos synthesis in di/di-rats in response to a metabolic stressor was normalised by AVP-AAV in both the SON and medial amygdala (MeA), but not in the central and basolateral amygdala or lateral hypothalamus. In vitro electrophysiological recordings showed an AVP-induced inhibition of MeA neurons that was prevented by picrotoxin administration, supporting the possible regulatory role of AVP originating in the SON. A memory deficit in the novel object recognition test seen in di/di animals remained unaffected by AVP-AAV treatment. Interestingly, although di/di rats show intact social investigation and aggression, the SON AVP-AAV treatment resulted in an alteration of these social behaviours. AVP released from the magnocellular SON neurons may stimulate adrenocorticotropin secretion in response to defined stressors and might participate in the fine-tuning of social behaviour with a possible contribution from the MeA.

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“…Two reported on 'amnesic' effects of oxytocin; these were associated with the theory that vasopressin enhances certain forms of memory, a theory that encountered intense criticism in the 1980s and was largely abandoned. 62 The third reported effects of oxytocin on maternal behaviour. Virgin or pregnant rats pay little attention to pups placed in their cage, but, after she has given birth, a mother rat will build a nest into which she will gather not only her own pups, but also any strange pups that are introduced into the cage.…”

Section: -79: Immunoassays and Immunohistochemistrymentioning

confidence: 99%

Oxytocin: A citation network analysis of 10 000 papers

Leng

2021

J Neuroendocrinology

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In 2002, Gainer et al 1 described the hypothalamic-neurohypophysial system, comprising the neurones that secrete oxytocin and vasopressin from the posterior pituitary, as "a veritable 'Rosetta Stone' for neuroendocrinology and neuroscience". Amongst the "many seminal findings" that came from this system, they highlighted the discovery and characterisation of neuropeptides, 2 the development of peptide agonists and antagonists, 3 the proposal of the prohormone concept, 4 the characterisation of bursting pacemaker activity in central nervous system neurones, 5 and the demonstrations of neuropeptide secretion from dendrites, 6 of glial-neuronal plasticity 7 and that peptides can produce complex behaviours. 8 We felt prompted to ask whether this system might also be valuable for understanding how scientific understanding develops. We sought to trace how knowledge about oxytocin has changed and is changing, and how that understanding varies in the works of different scientists pursuing different research objectives. To do this, we use a systematic search to capture a large part of the oxytocin literature, and we use citation network analysis to identify its structure, clustering papers according to their citation links.We begin with a brief account of the beginning of the oxytocin field. We then analyse each cluster to identify its topic focus, and show how the field has evolved since 1950, using bibliometric data to identify highly-cited papers. We do not assume that high citation counts define the best papers, but only that they indicate the changing foci of scientific activity. By this, we sketch out an outline of a history of oxytocin research -of the different perspectives of what oxytocin is and does, and what some might hope it might do. Our aim is to provide a sense of the diverse research questions, ideas, and findings that have motivated, and continue to motivate, research on oxytocin. And, by examining the publication and citation dynamics of this field over the last 70 years, we hope to help the reader to better understand the publication and citation metrics that continue to pervade and distort academia. 9 | ME THODSOxytocin was the first peptide hormone whose sequence was established, and the first to be synthesised; its gene was amongst the first mammalian genes to be sequenced, 10 and it has been a

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The vasopressin−memory hypothesis: a citation network analysis of a debate

Cited by 9 publications

References 103 publications

Comparison of the distribution of oxytocin and vasopressin 1a receptors in rodents reveals conserved and derived patterns of nonapeptide evolution

Comparison of the distribution of oxytocin and vasopressin 1a receptors in rodents reveals conserved and derived patterns of nonapeptide evolution

Rescue of Vasopressin Synthesis in Magnocellular Neurons of the Supraoptic Nucleus Normalises Acute Stress-Induced Adrenocorticotropin Secretion and Unmasks an Effect on Social Behaviour in Male Vasopressin-Deficient Brattleboro Rats

Oxytocin: A citation network analysis of 10 000 papers

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