The venous return simulator: comparison of simulated with measured ambulatory venous pressure in normal subjects and in venous valve incompetence

Chauveau, M.; Gelade, P; Cros, Françoise

doi:10.1024/0301-1526/a000095

Cited by 4 publications

(1 citation statement)

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“…A validation study of the VRS has been performed by comparing the values of ambulatory venous pressure (AVP) computed by the VRS, with AVP values reported in literature. In normal subjects , as well as in three schematic cases of valve incompetence (great saphenous vein (GSV), deep veins and combined incompetence), the computed AVP was in agreement with values reported in patients with similar valve defects; computed AVP increasing as the extent of valve defects was increased (9).…”

Section: Dogma: Is a Pressure Gradient The Best Way To Improve Haemodsupporting

confidence: 83%

Dogmas and controversies in compression therapy: report of an International Compression Club (ICC) meeting, Brussels, May 2011

Flour

Clark

Partsch³

et al. 2012

International Wound Journal

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The International Compression Club (ICC) is a partnership between academics, clinicians and industry focused upon understanding the role of compression in the management of different clinical conditions. The ICC meet regularly and from these meetings have produced a series of eight consensus publications upon topics ranging from evidence-based compression to compression trials for arm lymphoedema. All of the current consensus documents can be accessed on the ICC website (http://www.icc-compressionclub.com/index.php). In May 2011, the ICC met in Brussels during the European Wound Management Association (EWMA) annual conference. With almost 50 members in attendance, the day-long ICC meeting challenged a series of dogmas and myths that exist when considering compression therapies. In preparation for a discussion on beliefs surrounding compression, a forum was established on the ICC website where presenters were able to display a summary of their thoughts upon each dogma to be discussed during the meeting. Members of the ICC could then provide comments on each topic thereby widening the discussion to the entire membership of the ICC rather than simply those who were attending the EWMA conference. This article presents an extended report of the issues that were discussed, with each dogma covered in a separate section. The ICC discussed 12 'dogmas' with areas 1 through 7 dedicated to materials and application techniques used to apply compression with the remaining topics (8 through 12) related to the indications for using compression.

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Section: Dogma: Is a Pressure Gradient The Best Way To Improve Haemodsupporting

confidence: 83%

Dogmas and controversies in compression therapy: report of an International Compression Club (ICC) meeting, Brussels, May 2011

Flour

Clark

Partsch³

et al. 2012

International Wound Journal

View full text Add to dashboard Cite

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Pathophysiology of Reflux

Gianesini

Zamboni

2013

Phlebology, Vein Surgery and Ultrasonography

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Biaxial mechanical properties of bovine jugular venous valve leaflet tissues

Huang

2017

Biomech Model Mechanobiol

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Venous valve incompetence has been implicated in diseases ranging from chronic venous insufficiency (CVI) to intracranial venous hypertension. However, while the mechanical properties of venous valve leaflet tissues are central to CVI biomechanics and mechanobiology, neither stress-strain curves nor tangent moduli have been reported. Here, equibiaxial tensile mechanical tests were conducted to assess the tangent modulus, strength and anisotropy of venous valve leaflet tissues from bovine jugular veins. Valvular tissues were stretched to 60% strain in both the circumferential and radial directions, and leaflet tissue stress-strain curves were generated for proximal and distal valves (i.e., valves closest and furthest from the right heart, respectively). Toward linking mechanical properties to leaflet microstructure and composition, Masson's trichrome and Verhoeff-Van Gieson staining and collagen assays were conducted. Results showed: (1) Proximal bovine jugular vein venous valves tended to be bicuspid (i.e., have two leaflets), while distal valves tended to be tricuspid; (2) leaflet tissues from proximal valves exhibited approximately threefold higher peak tangent moduli in the circumferential direction than in the orthogonal radial direction (i.e., proximal valve leaflet tissues were anisotropic; [Formula: see text]); (3) individual leaflets excised from the same valve apparatus appeared to exhibit different mechanical properties (i.e., intra-valve variability); and (4) leaflets from distal valves exhibited a trend of higher soluble collagen concentrations than proximal ones (i.e., inter-valve variability). To the best of the authors' knowledge, this is the first study reporting biaxial mechanical properties of venous valve leaflet tissues. These results provide a baseline for studying venous valve incompetence at the tissue level and a quantitative basis for prosthetic venous valve design.

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The venous return simulator: comparison of simulated with measured ambulatory venous pressure in normal subjects and in venous valve incompetence

Abstract: the good agreement between computed and measured AVP in different cases of valve incompetence indicates that the VRS is quite a realistic model, with the potential to simulate the results of surgery or compression therapy.

Cited by 4 publications

References 0 publications

Dogmas and controversies in compression therapy: report of an International Compression Club (ICC) meeting, Brussels, May 2011

Dogmas and controversies in compression therapy: report of an International Compression Club (ICC) meeting, Brussels, May 2011

Pathophysiology of Reflux

Biaxial mechanical properties of bovine jugular venous valve leaflet tissues

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