The vesicle formation of β-CD and AD self-assembly of dumbbell-shaped amphiphilic triblock copolymer

Xu, Lujuan; Liang, Xiaofang; Zhang, Lin; Wu, Jinbi; Li, Zhanxian; Yu, Mingming; Wei, Liuhe

doi:10.1007/s00396-015-3758-6

Cited by 2 publications

(1 citation statement)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, a large number of polycations, including polylactic acid (PLA) [5], polycaprolactone (PCL) [6], cyclodextrin (CD) [7], polyethylene glycol (PEG) [8], poly(tertiary amine methacrylate) [9], polyvinyl phosphonic acid (PVPA) [10], glycidyl methacrylate (GMA) [11], poly(Nisopropylacrylamide) (PNIPAM) [12] have been reported for drug delivery in biomaterials and biomedical applications. CDs are a series of cyclic oligosaccharides composed of six, seven, or eight D(+)-glucose units linked by α-1,4-linkages, referred to as α-, β-, or γ-CD, respectively [13][14][15], which exhibit certain hydrophilicity and environmental friendliness. Hence, CDs are widely used as drug carriers.…”

Section: Introductionmentioning

confidence: 99%

Preparation and In Vitro Drug Release Behavior of 1,10-Phenanthroline/β-cyclodextrin–poly (Glycidyl Methacrylate) Drug-Loaded Microspheres

Wang¹,

Zhen²

2017

J. Res. Updates Polym. Sci.

View full text Add to dashboard Cite

In this study, novel star-shaped polymers of β-cyclodextrin (β-CD)-poly (glycidyl methacrylate) (PGMA) were prepared by atom transfer radical polymerization (ATRP), formed from GMA and β-CD. In addition, the structure, properties and hydrophilicity of the β-CD-PGMA polymers thus prepared were systematically analyzed. 1,10phenanthroline monohydrate (Phen)/β-CD-PGMA drug-loaded microspheres were prepared by emulsion solvent evaporation. The optimum preparation conditions were determined by orthogonal tests. Analysis results indicated that the performance of star-shaped polymers of β-CD-PGMA clearly changes, resulting in the increase of the contact angle from 17° to 72.5°, and their thermal degradation temperature was enhanced from 260 °C to 401 °C. Moreover, β-CD-PGMA drug-loaded microspheres with a smooth, spherical surface were successfully prepared, and the drug-loading capacity and average particle size of drug-loaded microspheres were 26.67 % and 10 µm, respectively. Drug release tests indicated that the release behavior of β-CD-PGMA drug-loaded microspheres conformed to Higuchi release kinetics, which exhibited a significant drug delivery capability. The release rate and utilization of β-CD-PGMA were greater than that of β-CD, demonstrating that β-CD-PGMA was more suitable as a drug delivery material.

show abstract