2022
DOI: 10.3390/v14061134
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The Virus–Host Interplay in Junín Mammarenavirus Infection

Abstract: Junín virus (JUNV) belongs to the Arenaviridae family and is the causative agent of Argentine hemorrhagic fever (AHF), a severe human disease endemic to agricultural areas in Argentina. At this moment, there are no effective antiviral therapeutics to battle pathogenic arenaviruses. Cumulative reports from recent years have widely provided information on cellular factors playing key roles during JUNV infection. In this review, we summarize research on host molecular determinants that intervene in the different … Show more

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Cited by 11 publications
(13 citation statements)
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“…Regarding the Gene Ontology Analysis from the differentially expressed genes, it was concluded that JUNV infection impacts the expression of genes related to RNA metabolism, host kinases, and lipid metabolism ( Figure 1 c). It is worth noting that these biological processes and molecular functions have been reported to be targeted by JUNV during its replication cycle [ 23 ].…”
Section: Resultsmentioning
confidence: 99%
“…Regarding the Gene Ontology Analysis from the differentially expressed genes, it was concluded that JUNV infection impacts the expression of genes related to RNA metabolism, host kinases, and lipid metabolism ( Figure 1 c). It is worth noting that these biological processes and molecular functions have been reported to be targeted by JUNV during its replication cycle [ 23 ].…”
Section: Resultsmentioning
confidence: 99%
“…It is affected by lipid rafts and cholesterol content. As mentioned earlier, Z protein being the main driving force in the budding process and release is associated with certain host targets, such as IMPDH2 and the ATP‐synthase ATP5B, which facilitates viral egress to complete the viral cycle 44 . To sustain the Junin budding, certain constituents such tumour susceptibility gene 101 protein (Tsg‐101) and vacuolar protein sorting 4A or 4B (VPS4A/B) are strictly needed for transport (ESCRT) 45 …”
Section: Nature Of Infectious Agents (Structural and Molecular)mentioning
confidence: 99%
“…This leads to the production of IFN‐I, which is then released and identified by the IFN‐α/β receptor (IFNAR). This results in the activation of various IFN‐stimulated genes, which plays a crucial role in attaining the antiviral state required to act against viral growth 44 …”
Section: Pathogenesis In Humansmentioning
confidence: 99%
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