The Visceral Adiposity Index in Non-Alcoholic Fatty Liver Disease and Liver Fibrosis—Systematic Review and Meta-Analysis

Ismaiel, Abdulrahman; Jaaouani, Ayman; Leucuţa, Daniel-Corneliu; Popa, Stefan-Lucian; Dumitraşcu, Dan L.

doi:10.3390/biomedicines9121890

Cited by 30 publications

(22 citation statements)

References 91 publications

(164 reference statements)

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“…Emerging evidence suggests that fatty liver indices might be associated with indices of atherosclerosis [ 24 , 25 , 26 ]. The visceral adiposity index (VAI) and metabolic score for visceral fat (METS-VF) are novel estimates of intra-abdominal fat content and cardio-metabolic health [ 27 , 28 ]. In addition, there is a validated surrogate of body composition-derived adiposity called the body adiposity index (BAI) [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Curcumin Offers No Additional Benefit to Lifestyle Intervention on Cardiometabolic Status in Patients with Non-Alcoholic Fatty Liver Disease

et al. 2022

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Cardiovascular disease (CVD) is the leading cause of death in patients with non-alcoholic fatty liver disease (NAFLD). Curcumin has been shown to exert glucose-lowering and anti-atherosclerotic effects in type 2 diabetes. Hence, we investigated curcumin’s effects on atherogenesis markers, fatty liver, insulin resistance, and adipose tissue-related indicators in patients with NAFLD. In this secondary analysis of a 12-week randomized controlled trial, fifty-two patients with NAFLD received lifestyle modification. In addition, they were randomly allocated to either the curcumin group (1.5 g/day) or the matching placebo. Outcome variables (assessed before and after the study) were: the fatty liver index (FLI), hepatic steatosis index (HSI), fatty liver score (FLS), BMI, age, ALT, TG score (BAAT), triglyceride glucose (TyG) index, Castelli risk index-I (CRI-I), Castelli risk index-II (CRI-II), TG/HDL–C ratio, atherogenic coefficient (AC), atherogenic index of plasma (AIP), lipoprotein combine index (LCI), cholesterol index (CHOLINDEX), lipid accumulation product (LAP), body adiposity index (BAI), visceral adiposity index (VAI), metabolic score for visceral fat (METS-VF), visceral adipose tissue (VAT), and waist-to-height ratio (WHtR) values. The TyG index decreased in the curcumin group and increased in the placebo group, with a significant difference between the groups (p = 0.029). However, a between-group change was not significant after adjustment for multiple testing. Other indices were not significantly different between the groups either before or after multiple test correction. After the intervention, there was a lower number of patients with severe fatty liver (FLI ≥ 60) and metabolic syndrome in the curcumin group compared to the placebo (p = 0.021 and p = 0.012, respectively). In conclusion, curcumin offers no additional cardiometabolic benefits to lifestyle intervention in patients with NAFLD.

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Section: Introductionmentioning

confidence: 99%

Curcumin Offers No Additional Benefit to Lifestyle Intervention on Cardiometabolic Status in Patients with Non-Alcoholic Fatty Liver Disease

et al. 2022

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“…Increasing evidence revealed that the accumulation of visceral adipose tissue was a strong predictor of the occurrence of NAFLD. In the case of similar body weight, people with a higher proportion of visceral fat were more prone to develop NAFLD (23,24). In this study, the visceral adipose tissues in the model group markedly increased and the morphology of epididymal adipose tissue was abnormal mainly characterized by the expansive sizes and irregular shapes of adipocytes.…”

Section: Effects Of Green Teas On Visceral Adipose Tissuementioning

confidence: 52%

“…On the other hand, epididymal adipocytes in the different green tea groups were significantly smaller and had more regular shapes compared with the model group.Increasing evidence revealed that the accumulation of visceral adipose tissue was a strong predictor of the occurrence of NAFLD. In the case of similar body weight, people with a higher proportion of visceral fat were more prone to develop NAFLD(23,24). In this study, the visceral adipose tissues in the model group markedly increased and the morphology of…”

mentioning

confidence: 48%

Effects of Different Green Teas on Obesity and Non-Alcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice

Zhou

Mao

et al. 2022

Front. Nutr.

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Non-alcoholic fatty liver disease (NAFLD) and obesity are serious public health problems. Green tea is widely consumed in the world and different green teas could possess different bioactivities. In this study, the effects of 10 selected green teas on obesity and NAFLD were evaluated and compared. The mice fed with a high-fat diet were intervened with green tea extract (200 mg/kg body weight) for 15 weeks. Most of these teas were first evaluated for their effects on obesity and NAFLD. The results showed that Selenium-Enriched Chaoqing Green Tea and Jieyang Chaoqing Tea showed the most prominent inhibition of obesity and body weight gains of mice in these two tea intervention groups and model groups were 5.3, 5.5, and 13.7 g, respectively. In addition, Jieyang Chaoqing Tea, Taiping Houkui Tea, and Selenium-Enriched Chaoqing Green Tea exerted the most notable effect on NAFLD, which was attributed to decreasing body weight, and lipid content and ameliorating oxidative stress. Furthermore, 13 phytochemicals were determined in these teas by high-performance liquid chromatography and the correlation analysis found that epigallocatechin gallate, gallocatechin, and epigallocatechin might contribute to the decrease of hepatic weight, while epicatechin might reduce oxidative stress. In general, several green teas could prevent the development of obesity and NAFLD and could be developed into functional foods. This study was also helpful for the public to select appropriate tea to prevent obesity and NAFLD.

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“…In a study comprised of 142 NAFLD patients, liver biopsies were conducted, and visceral adiposity index was used as a clinical measurement with the assessment of serum levels of different cytokines. The study found the independent correlation of insulin resistance and visceral adiposity index with significant fibrosis in NAFLD [113] . A review of 24 studies reported the visceral adiposity index as a predicting factor in the diagnosis of NASH and NAFLD and a higher value of visceral adiposity index in NAFLD patients as compared to persons without NAFLD [114] .…”

Section: Correlation Of Sarcopenia and Nafldmentioning

confidence: 71%

Sarcopenia in the setting of nonalcoholic fatty liver

Arrese¹,

Cabello-Verrugio²,

Arab³

et al. 2022

MTOD

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Nonalcoholic fatty liver is a worldwide common problem with more prevalence in non-Asian populations that is closely correlated with the muscle-related disorder sarcopenia. The incidence of both health issues has been observed to be strongly interlinked where presence of one exacerbates the other. Nonalcoholic fatty liver disease (NAFLD) pathophysiology increases the muscle loss, while the onset of NAFLD in sarcopenic patients aggravates the liver problems as compared to non-sarcopenic patients. Scarcity of research on the subject provides very little evidence about the cause and effect of disorders. No FDA approved drugs are available to date for NAFLD and sarcopenia. Research is underway to understand the complex biochemical pathways involved in the development of both disorders. This review is a small contribution toward understanding sarcopenia in the setting of NAFLD that provides insight on the common pathophysiological profile of sarcopenia and NAFLD and portrays a novel way of delving into the subject by introducing the concept of cortisol crosstalk with the muscle-liver axis. Sarcopenia and NAFLD are considered metabolism-related problems, and cortisol, being a glucocorticoid, plays an important role in metabolism of fats, carbohydrates, and proteins. Cushing’s syndrome, characterized by abnormally elevated concentrations of blood cortisol/enhanced intracellular activity, shares many pathologic conditions (such as insulin resistance, metabolic syndrome, abnormal levels of specific cytokines, and obesity) with NAFLD and sarcopenia. Hence, cortisol can be a potential biomarker in sarcopenia and NAFLD. As cortisol activity at cellular level is controlled by 11β-hydroxysteroid dehydrogenase type 1 and 2 (11β-HSD1/2) enzymes that convert inactive steroid precursor into active cortisol, these enzymes can be targeted for the study of sarcopenia and NAFLD. Combined studies on NAFLD and sarcopenia with respect to cortisol open a new avenue of research in the understanding of both disorders.

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The Visceral Adiposity Index in Non-Alcoholic Fatty Liver Disease and Liver Fibrosis—Systematic Review and Meta-Analysis

Cited by 30 publications

References 91 publications

Curcumin Offers No Additional Benefit to Lifestyle Intervention on Cardiometabolic Status in Patients with Non-Alcoholic Fatty Liver Disease

Curcumin Offers No Additional Benefit to Lifestyle Intervention on Cardiometabolic Status in Patients with Non-Alcoholic Fatty Liver Disease

Effects of Different Green Teas on Obesity and Non-Alcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice

Sarcopenia in the setting of nonalcoholic fatty liver

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