The visualisation of fissionable radionuclides in rat lung using neutron induced autoradiography

Gore, D J; Thorne, M C; Watts, R H

doi:10.1088/0031-9155/23/1/015

Cited by 23 publications

(2 citation statements)

References 1 publication

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“…After neutron exposure, a 238Pu a-particle shadow image of the lung section was produced in the CR-39 using the method of Gore et al (12). This method creates a reasonably good resolution tissue image of the lung section while retaining the neutroninduced 235U fission fragment tracks.…”

Section: Locating Uo2 Particles Within the Tissue Sectionmentioning

confidence: 99%

Dosimetric Implications of Pulmonary Macrophage Clusters Observed within Lungs of Rats That Have Inhaled Enriched UO 2 Particles

Morris¹,

Barker²,

Batchelor³

et al. 1992

Environmental Health Perspectives

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Twenty-four Fischer 344 rats were exposed to enriched uranium dioxide (UO2) aerosols to give a mean initial lung burden of 291 +/- 89 (SD) micrograms. Groups of rats were killed at 1, 7, 180, 360, 540, and 720 days post-inhalation (PI). Their lungs were fixed and inflated. Sections cut from all five lung lobes were used to prepare CR-39 neutron-induced 235U fission fragment autoradiographs. A single traverse across a CR-39 autoradiograph of a tissue section, from the left lung of all the rats, was made using a motorized microscopic stage. The traverse was divided into 10 fields. The track counts per field were used to test for homogeneity of track distribution and to assess if there was any tendency for tracks to be related to the peripheral region of the lung. Full raster scans across the entire tissue image were made on left lung autoradiographs from two animals killed at each time point to assess the homogeneity of fission fragment track distribution throughout the entire section. There was no evidence of any temporal change in the proportion of tracks associated with the lung periphery. At all time points PI, the track distribution was significantly nonhomogeneous, suggesting a nonuniform pattern of tissue irradiation from the 234U alpha particles. At time points from 180 to 720 days PI, large clusters of macrophages were observed in some of the sections taken from all five lung lobes. The total number of macrophage clusters increased with time PI. These macrophage clusters produced many 235U fission fragment tracks within the CR-39 autoradiographs.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Locating Uo2 Particles Within the Tissue Sectionmentioning

confidence: 99%

Dosimetric Implications of Pulmonary Macrophage Clusters Observed within Lungs of Rats That Have Inhaled Enriched UO 2 Particles

Morris¹,

Barker²,

Batchelor³

et al. 1992

Environmental Health Perspectives

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show abstract

“…Thus the distribution of U was shown superimposed on an image of the lung tissue. 37 In later work, Gore and Jenner 38 replaced the Lexan with CR-39. Henshaw et a/.…”

Section: Biological Applicationsmentioning

confidence: 99%

Further Applications of Track Detectors and Some Directions for the Future

Durrani

1987

Solid State Nuclear Track Detection

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Microanatomical localisation of fissionable elements in histological sections using Lexan replicas

Wyatt¹,

Dixon²,

Bentley³

1981

Nuclear Tracks

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The visualisation of fissionable radionuclides in rat lung using neutron induced autoradiography

Cited by 23 publications

References 1 publication

Dosimetric Implications of Pulmonary Macrophage Clusters Observed within Lungs of Rats That Have Inhaled Enriched UO 2 Particles

Dosimetric Implications of Pulmonary Macrophage Clusters Observed within Lungs of Rats That Have Inhaled Enriched UO 2 Particles

Further Applications of Track Detectors and Some Directions for the Future

Microanatomical localisation of fissionable elements in histological sections using Lexan replicas

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