The vitamin D receptor gene<b><i>Bsm</i></b>I polymorphism is not associated with anthropometric and biochemical parameters describing metabolic syndrome in postmenopausal women

Tworowska-Bardzińska, Urszula; Lwow, Felicja; Kubicka, Eliza; Łaczmański, Łukasz; Jedzrzejuk, Diana; Dunajska, Katarzyna; Milewicz, Andrzej

doi:10.1080/09513590802302985

Cited by 43 publications

(26 citation statements)

References 25 publications

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“…These studies support the notion that haplotype 1 may be associated with survival benefit, as was shown by a tendency in this study. Studies examining the associations between the BsmI, ApaI, and TaqI polymorphisms and cardiovascular risk factors, such as blood pressure and lipid profile, have shown conflicting results (8,15,38). In this study, the HR was not influenced by correction for several cardiovascular risk factors, suggesting that the effect is not mediated by these factors.…”

Section: Discussionmentioning

confidence: 49%

Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals

Jongh

Lips

Rijs

et al. 2011

European Journal of Endocrinology

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Context: Vitamin D receptor (VDR) polymorphisms are associated with a variety of diseases, which may translate into an effect on mortality. Objective: To investigate the associations between VDR gene variants and mortality among older people. Design: The analyses were conducted in a population-based, prospective cohort of the Longitudinal Aging Study Amsterdam. Adequate DNA analysis was performed in 923 men and women (R65 years). We aimed to assess the associations between mortality and the VDR polymorphism FokI, three haplotypes of the Cdx2 and GATA polymorphisms, and three haplotypes of the BsmI, ApaI, and TaqI polymorphisms. Results: During the median follow-up of 10.7 years, 480 participants deceased (51%). Homozygosity for the Cdx2-GATA haplotype 1 allele was associated with a 30% higher mortality risk compared to the absence of alleles (hazard ratios (HR) 1.30, 95% confidence intervals (CI) 1.01-1.68). Adjustment for cardiovascular risk factors and 25-hydroxyvitamin D levels did not affect this HR. The number of copies of the Cdx2-GATA haplotype 1 allele was associated, although not significantly, with an increased risk of osteoporotic fractures (0 copiesZreference, HR, 95% CI: 1 copy 2.01, 0.99-4.07 and 2 copies 1.81, 0.87-4.18). After adjustment for osteoporotic fractures, homozygosity for the Cdx2-GATA haplotype 1 allele was no longer associated with higher mortality risk (HR 1.08, 95% CI 0.83-1.41).

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Section: Discussionmentioning

confidence: 49%

Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals

Jongh

Lips

Rijs

et al. 2011

European Journal of Endocrinology

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“…These consistent findings for Bsm I and obesity with the risk increasing allele being ‘A’ were confirmed when the phenotypes of interest were type 2 diabetes, fasting glucose level and CHD risk in recent studies ( 13 , 14 ) . In contrast, among 351 postmenopausal healthy women, VDR Bsm I polymorphism (‘A’ risk allele) was not associated with obesity or insulin resistance but was connected with an unfavourable lipid profile ( 36 ) . Additionally, a case–control study with 309 unrelated French subjects with type 2 diabetes, and among those with early onset in particular, the Taq I SNP (‘A’ allele) was associated with a higher BMI and an increased prevalence of obesity, compared with the controls ( 16 ) .…”

Section: Discussionmentioning

confidence: 99%

“…Several recent cross-sectional and case–control studies have examined VDR genetic polymorphisms as potential risk markers for central adiposity and related metabolic disorders ( 9 – 11 , 16 , 17 , 36 , 37 ) . When testing VDR SNP associations with adiposity, a recent cross-sectional study (176 randomly selected men aged 25–65 years) found that homozygous BsmI (AA v. GG) was associated with higher BMI (29·0 v. 26·8 kg/m 2 ; P = 0·024) and higher WC (101·8 v. 96·2 cm; P = 0·014) ( 11 ) .…”

Section: Discussionmentioning

confidence: 99%

Vitamin D receptor and megalin gene polymorphisms are associated with central adiposity status and changes among US adults

et al. 2013

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We examined longitudinal associations of vitamin D receptor (VDR) and megalin (LRP2; LDL receptor-related protein-2) gene polymorphisms with central adiposity. We used data from the Baltimore Longitudinal Study of Aging (BLSA), an ongoing prospective open cohort study. Study participants consisted of non-Hispanic white adults residing in Baltimore city, with one or more visits at age ≥50 years, and complete data (n 609–617). Repeated assessments on waist circumference (WC) and waist:hip ratio (WHR) were available. Multiple linear mixed models were used to estimate mid-follow-up age central adiposity level and annual rate of change with cut-points set at the sex-specific 80th percentile. The four binary outcomes were: ‘elevated central adiposity’ (ECA-WC and ECA-WHR) and ‘significant increase in central adiposity’ (SICA-WC and SICA-WHR). SNP for VDR (four SNP: (1) rs11568820 (CdX-2:T/C); (2) rs1544410 (BsmI:G/A); (3) rs7975232 (ApaI:A/C); (4) rs731236 (TaqI:G/A)) and Megalin (three SNP: (1) rs3755166:G/A; (2) rs2075252:C/T; (3) rs4668123:C/T) genes were selected. SNP latent classes (SNPLC) and SNP haplotypes (SNPHAP) were created. Multiple logistic regression analyses indicated that, in men, higher ECA-WHR odds were associated with SNPLC Megalin2:rs3755166[–]/rs2075252[TT]/rs4668123[T–] (v. Megalin1:rs3755166[–]/rs2075252[CC]/rs4668123[–]) (OR 2·87; 95 % CI 1·15, 7·12; P = 0·023) and that SNPLC Megalin3:rs3755166[–]/rs2075252[CT]/rs4668123[–] (v. Megalin1) was linked to lower SICA-WC odds (OR 0·48; 95 % CI 0·26, 0·88; P = 0·019) (P > 0·05 for sex × SNPLC). In women, VDR3 SNPHAP (GAA:bAT) was related to lower odds of ECA-WC (OR 0·37; 95 % CI 0·16, 0·87; P = 0·023) (P < 0·05 for sex × SNPHAP), VDR1 SNPHAP (GCA:baT) was associated with greater odds and VDR3 SNPHAP (GAA:bAT) with lower odds of SICA-WC (P > 0·05 for sex × SNPHAP). Vitamin D-related gene polymorphisms were associated with central adiposity status and change. Future mechanistic studies are needed to confirm those polymorphisms' biological significance to central adiposity.

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“…VDR BsmI and FokI polymorphisms have been previously reported to be associated with anthropometric and biochemical parameters describing MS. Trzmiel et al (2008) found that VDR BsmI polymorphism seemed to influence BMI, while the FokI VDR polymorphism appeared to affect insulin sensitivity and serum HDL cholesterol in men [24]. However, Lwow et al (2008) indicated that VDR BsmI polymorphism did not seem to predispose postmenopausal women to obesity and insulin resistance, but the genotype BB was connected with dyslipidemia [30]. Frey et al (2003) did not find evidence for the association of VDR polymorphisms with glycemia either [31].…”

Section: Discussionmentioning

confidence: 99%

Association of vitamin D receptor gene polymorphisms with metabolic syndrome: a case–control design of population-based cross-sectional study in North China

Zhao

Liao

et al. 2014

Lipids Health Dis

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BackgroundMetabolic syndrome (MS) increases a risk of developing cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). The Vitamin D Receptor gene (VDR) may be important for developing MS. The aim of this study is to investigate the correlation between the VDR gene polymorphisms and MS in North China.MethodsA case–control study included 391 participants with MS according to the MS diagnostic criteria of International Diabetes Federation 2005 (IDF2005) and 400 controls was conducted on the basis of a cross sectional study which was performed from 2008 to 2012 in Ningxia Hui Autonomous Region, China. Anthropometric data, blood pressure and blood samples were collected in the field investigation. Blood biochemistry analyses were carried out in the laboratory. Two single-nucleotide polymorphisms (SNPs) in the VDR gene, BsmI (rs1544410 A > G) and FokI (rs 2228570 C > T), were genotyped.ResultsThe difference in the occurrence of genotypes in BsmI between individuals with MS and the control group was significant. Compared with genotype Bb/bb and allele b, genotype BB and allele B showed higher frequencies in MS cases than controls, which suggested they were risk factors. In addition, the genotype BB carriers with MS presented a higher waist circumference, while genotype FF for the FokI polymorphism was correlated with lower BMI in subjects with MS.ConclusionOur study suggests that the VDR gene polymorphisms appear to be associated with MS in the Northern Chinese population. Allele B and BB genotype for BsmI are risk factors for MS. The BsmI polymorphism seems to influence waist circumference, while the FokI polymorphism influence BMI in subjects with MS.

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The vitamin D receptor geneBsmI polymorphism is not associated with anthropometric and biochemical parameters describing metabolic syndrome in postmenopausal women

Abstract: The BsmI polymorphism in the VDR gene does not seem to predispose to obesity and insulin resistance, but the BB genotype is connected with an unfavorable lipid profile.

Cited by 43 publications

References 25 publications

Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals

Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals

Vitamin D receptor and megalin gene polymorphisms are associated with central adiposity status and changes among US adults

Association of vitamin D receptor gene polymorphisms with metabolic syndrome: a case–control design of population-based cross-sectional study in North China

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