The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain

Cui, Xiaoying; Pelekanos, Matthew; Liu, P.-Y.; Burne, Thomas H. J.; McGrath, John J.; Eyles, Darryl W.

doi:10.1016/j.neuroscience.2013.01.035

Cited by 159 publications

(141 citation statements)

References 57 publications

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“…A significant concentration of vitamin D receptors was found in the hippocampus, in the prefrontal cortex-brain and in the substantia nigra [260]. There is evidence of low-levels of vitamin D, and increased bone turnover markers, such as bone alkaline phosphatase compared to controls [261].…”

Section: Vitamin D Deficiency and Neurodegenerative Diseasesmentioning

confidence: 93%

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Moretti

Morelli

Caruso

2018

Preprint

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It is widely known that vitamin D receptors have been found in neurons and glial cells and their highest expression is in the hippocampus, hypothalamus, thalamus and subcortical grey nuclei, and substantia nigra. The vitamin D helps the regulation of neurotrophin, neural differentiation and maturation, through the control operation of growing factors synthesis (ie NGF and GDNF), the trafficking of the septo-hyppocampal pathway, and the control of the synthesis process of different neuromodulators (such as Ach, DA, and GABA).Based on these assumptions, we have written this review in order to summarize the potential role of vitamin D in neurological pathologies. The work could be titanic, and might result very fuzzy and even incoherent, if we would not have conjectured to taper our first intentions and devoted our interests towards three mainstreams: demyelinating pathologies, vascular syndromes and neurodegeneration.Due to the lack of effective therapeutic options, a part from the disease modifying strategies, the role of different risk factors should be investigated in neurology, as far as their correction may lead to the improvement of the cerebral conditions.We have explored the relationships between the gene-environmental influence and long term vitamin D deficiency, as a risk factor for the development of different types of neurological disorders, along with the role and the rationale of therapeutic trials with vitamin D implementation. Peer-reviewed version available at Int. J. Mol. Sci. 2018, 19, 2245 doi:10.3390/ijms19082245 3 SEARCH STRATEGY AND SELECTION CRITERIAWe searched MEDLINE using the search terms: "vitamin D central nervous system" , both "vitamin D" and "central nervous system"; "vitamin D immune system/response", both "vitamin D" and "immune system" or "immune response"; "vitamin D multiple sclerosis risk", both "vitamin D" and "multiple sclerosis risk"; "vitamin D multiple sclerosis relapse", both "vitamin D" and "multiple sclerosis relapse"; "vitamin D multiple sclerosis magnetic resonance imaging", both "vitamin D" and "multiple sclerosis magnetic resonance imaging"; "vitamin D multiple sclerosis disability", both "vitamin D" and "multiple sclerosis disability"; "vitamin D supplementation/therapy/treatment multiple sclerosis", both "vitamin D supplementation" or "vitamin D therapy" or "vitamin D treatment" and "multiple sclerosis"; "vascular dementia", both as -vascular-and -dementia-, "subcortical vascular dementia", both assubcortical-and -dementia-, "Alzheimer's disease", "pathogenesis neurodegeneration" "amyloid", "cholinergic afferents", "arteriolosclerosis", "cerebral flow regulation", "stroke". Publications were selected mostly form the past 20years, but did not exclude frequently referenced and highly regarded older publications. . Congress abstracts and isolated case reports were not considered. We searched the reference lists of articles identified by this search strategy and selected those we judged relevant. Review articles and book chapters are cited to provide with ...

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Section: Vitamin D Deficiency and Neurodegenerative Diseasesmentioning

confidence: 93%

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Moretti

Morelli

Caruso

2018

Preprint

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“…This is also evident in the fishes as the scales have been found not to only contribute to the biological adaptation of fishes in water (counter shading) but senses the environment and contribute to movement and balance [32]. The loss of melanin pigments coupled with synaptic denervation have been implicated in the etiology of PD [3]. This can be studied using this model as depolymerization of the MT will cause centralization of all melanosomes being conveyed on such microtubule tracts.…”

Section: Discussionmentioning

confidence: 99%

“…Deficiency of Vitamin D 3 or genetic mutations involving the VDR have been described in multi array organ malfunction especially in the SN, parathyroid gland, bone and gastrointestinal tract [1,2]. Vitamin D 3 Receptors (VDR) have been observed in the Substantia Nigra (SN) [3,4]; as well as in the skin and liver of the fish [5]. Our choice of the VDR and VDRA, in this study, is to establish in part, the cellular mechanism of Vitamin D 3 as a neuroprotective agent in PD especially as it involves process formation and prevention of synaptic denervation via signaling pathways that facilitates polymerization of MT.…”

Section: Introductionmentioning

confidence: 99%

VDR Potentiation and NMDA R Inhibition Facilitates Axo-Dendritic Process Formation in Melanocyte Model for Pigmented Cells in Parkinsonism

Michael

Ajonijebu²,

Chris³

et al. 2013

Cell Development Biol

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Background: A major cellular change in dopaminergic neurons leading to Parkinsonism is the alteration of microtubule proteins that causes accumulation of tau protein, α-syn and β-amyloid plaque in the cells. In this study we investigate the role of Vitamin D 3 in relieving the symptoms of Parkinsonism as it is capable of stimulating polymerization of microtubules. The Microtubules (MT) system in the fish scale melanocytes has been modeled for the dopaminergic neurons of the Substantia Nigra (SN). These cells are capable of forming cellular processes similar to what is seen in the dopaminergic neurons; in this study, we investigate the protective effect of Vitamin D 3 Receptor Agonist (VDRA) and N-Methyl-D-Aspartate Receptor (NMDA R) inhibition in process formation, synaptic denervation and melanin loss in fish scale melanocytes modeled as pigmented adrenergic cells.

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“…Consequently, vitamin D deficiency rodent models have been established to investigate the underlying neurobiology and discrete behavioral domains that are altered alongside dietary vitamin D. Vitamin D acts as a neuorosteroid via the nuclear vitamin D receptor (VDR), which appears in the rodent brain during the second half of embryonic development and continues to be expressed into adulthood [6,7]. Here, the VDR modulates processes such as neurogenesis, cell proliferation, differentiation, and neurotransmitter metabolism [8].…”

Section: Introductionmentioning

confidence: 99%

The impact of vitamin D deficiency on behaviour and brain function in rodents

Overeem

Eyles

McGrath

2016

Current Opinion in Behavioral Sciences

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Vitamin D deficiency has been proposed as an environmental risk factor for several neurological disorders. To investigate the biological plausibility of this risk factor, vitamin D (DVD) deficiency rodent models have been used to examine the impact of DVD deficiency on neurobiology and behaviour. The majority of these studies have taken a developmental stance and examined the impact of vitamin D deficiency during gestation on the adult behaviour of the offspring. In the rat, the most constant behavioural phenotypes include hyperlocomotion in response to novelty, psychostimulant sensitively, impulsivity, and augmented motivation. However, in the mouse increased exploratory behaviour and

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The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain

Cited by 159 publications

References 57 publications

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

VDR Potentiation and NMDA R Inhibition Facilitates Axo-Dendritic Process Formation in Melanocyte Model for Pigmented Cells in Parkinsonism

The impact of vitamin D deficiency on behaviour and brain function in rodents

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