The Volume and Composition of the Blood, and the Changes Incident to Diuresis, in Cases of Edema

Brown, George E.

doi:10.1001/archinte.1925.00120070134009

Arch Intern Med

1925

DOI: 10.1001/archinte.1925.00120070134009

|View full text |Cite

The Volume and Composition of the Blood, and the Changes Incident to Diuresis, in Cases of Edema

George E. Brown¹

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1926

1951

Publication Types

Select...

Article9

Relationship

Self Cite0

Independent9

Authors

Journals

Cited by 33 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the series of blood volumes reported to date on this question have been measured with the dye T-1824 (14), although other dyes have been used (5)(6)(7). The errors in the dye methods have been repeatedly pointed out (8)(9)(10)(11)(12)(13)(14)(15)(16).…”

mentioning

confidence: 99%

Total Red Cell Volume, Plasma Volume, and Sodium Space in Congestive Heart Failure 1

Prentice¹,

Berlin²,

Hyde³

et al. 1951

J. Clin. Invest.

View full text Add to dashboard Cite

mentioning

confidence: 99%

Total Red Cell Volume, Plasma Volume, and Sodium Space in Congestive Heart Failure 1

Prentice¹,

Berlin²,

Hyde³

et al. 1951

J. Clin. Invest.

View full text Add to dashboard Cite

“…In the present paper, only such results as seem to concern this work will be mentioned. The findings of the various workers seem fairly concordant and indicate that adults tend to have about 50 milliliters of plasma and 83 milliliters of blood per kilogram of body weight, as determined by the dye method (Keith, Rowntree and Geraghty (2) Bock (5), Brown ana Rowntree (6)). Bock has emphasized the fact that the plasma volume is more constant than the blood volume and has found it to be about 50 Robertson and Bock (7) found in soldiers who had lost large amounts of blood that the plasma volume returns quickly to normal unless the volume of the red cells has reached a certain low minimum.…”

mentioning

confidence: 88%

Blood Volume in Normal Infants and Children

Darrow¹,

Soule²,

Buckman³

1928

J. Clin. Invest.

View full text Add to dashboard Cite

Knowledge concerning blood volumes has been limited until recent years by the lack of any reliable method that could be applied to living patients. Information about the blood volume is desirable both for the study of anemia and of disturbances in the water metabolism. The work reported in this and the three subsequent papers was undertaken from the latter viewpoint.There are two reliable methods of determining blood volumes which may be applied to patients. They are (a) the carbon monoxide method, first adapted to man by Haldane and Smith (1) and (b) the dye method of Keith, Rowntree and Geraghty (2). The former method gives results that are probably a little lower than the actual blood volume whereas the latter gives results a little higher than the actual blood volumes. The high results by the dye method have been shown by Smith (3) to be due to transfusion of part of the dye into the lymph.However, the amount of dye disappearing in the lymph is small and fairly constant and the method is accurate for comparative results.Our knowledge of blood volumes has been recently reviewed by Erlanger (4). In the present paper, only such results as seem to concern this work will be mentioned.

show abstract

“…Blumgart, Gilligan, Levy, Brown, and Volk (4) concluded from observations on normal subjects that diuresis following xanthine and mercurial drugs was not initiated by the kidneys in response to measurable changes in specific gravity or sodium or chloride contents of the blood. Brown and Rowntree (5) found an increase in blood volume with the onset of diuresis in cardiac patients. On the other hand, using more accurate methods, Evans and Gibson (6) observed in dogs a diminution of plasma volume during diuresis induced by salyrgan.…”

mentioning

confidence: 97%

Mechanism of Diuresis: Alterations in the Specific Gravity of the Blood Plasma With Onset of Diuresis in Heart Failure

Stewart¹

1941

J. Clin. Invest.

View full text Add to dashboard Cite

There are divergent views concerning the mechanism by which diuresis is initiated. Many of the observations on this subject relate to mercurial drugs. Crawford and McIntosh (1) concluded that novasurol induced primary dilution, followed by concentration of the blood in edematous patients. Bryan, Evans, Fulton, and Stead (2) thought that salyrgan resulted in concentration of the blood, since sustained rise in its specific gravity occurred coincident with diuresis in dogs made edematous by plasmapheresis. Schmitz (3) did not find evidence that salyrgan mobilized fluid into the blood stream before the onset of diuresis. Blumgart, Gilligan, Levy, Brown, and Volk (4) concluded from observations on normal subjects that diuresis following xanthine and mercurial drugs was not initiated by the kidneys in response to measurable changes in specific gravity or sodium or chloride contents of the blood. Brown and Rowntree (5) found an increase in blood volume with the onset of diuresis in cardiac patients. On the other hand, using more accurate methods, Evans and Gibson (6) observed in dogs a diminution of plasma volume during diuresis induced by salyrgan.For purposes of analysis the circulatory-renal system consists of the kidneys on the one hand and the tissues which retain fluid on the other, the circulating blood connecting them. Tissue fluid to be excreted as urine must be carried by the blood to the kidneys. The stimulus to inaugurate diuresis may be applied at different points in this system. If the mechanism is initiated in the kidneys and increased secretion of urine is the first step, concentration of the blood should occur on the withdrawal of fluid from it. How far this imbalance in the blood constituents can proceed and how long it can be present before restoration occurs by the entrance of fluid from the edematous tissues might vary with different diuretics.Moreover, its duration may be brief before restoration is attempted, or it may be long enough and of such magnitude that it can be detected.On the other hand, if diuresis is initiated at the tissue side of the system so that fluid enters the blood stream first, dilution of the blood would occur. Equilibrium would be disturbed until the kidneys began to excrete the surplus fluid. If dilution of the blood was of sufficient duration and magnitude, it might be detected.It appeared that frequent observations of the specific gravity of the blood would reflect changes in dilution and concentration of the blood and give data which would contribute to one or the other of these points of view. Moore and Van Slyke (7) demonstrated a linear relationship between the observed specific gravity of the plasma of the blood and the observed protein content of the plasma of normal individuals and nephritic patients. They found also that when the specific gravity of the plasma was below 1.0223 in certain types of nephritis, edema was present, and that when the specific gravity was above this level, the so-called edema zone, edema did not occur.In cardiac patients, Moore and Stewa...

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The Volume and Composition of the Blood, and the Changes Incident to Diuresis, in Cases of Edema

Cited by 33 publications

References 7 publications

Total Red Cell Volume, Plasma Volume, and Sodium Space in Congestive Heart Failure 1

Total Red Cell Volume, Plasma Volume, and Sodium Space in Congestive Heart Failure 1

Blood Volume in Normal Infants and Children

Mechanism of Diuresis: Alterations in the Specific Gravity of the Blood Plasma With Onset of Diuresis in Heart Failure

Contact Info

Product

Resources

About