The Wetting and Dissolution Rate of Phenobarbitone Powders

Mohammad, Hussain; Fell, John T.

doi:10.3109/03639048309048553

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…Surface energy measurements were performed using the approach described by Telko and Hickey and does not assume the entropic contributions to Gibb's free energy of adsorption can be neglected (Mohammad & Fell, 1983) glass columns and plugged with silanated glass wool. After the temperature was changed, the packed column was allowed to equilibrate for 4 hours before subsequent injections were made.…”

Section: Surface Energy Analysis Of Lactosementioning

confidence: 99%

Prediction of Dry Powder Inhaler Formulation Performance From Surface Energetics and Blending Dynamics

Saleem

Smyth

Telko

2008

Drug Development and Industrial Pharmacy

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The Purpose of these studies was to investigate the ability of surface energy measurements and rates of mixing in dry powder inhaler formulations to predict aerosol dispersion performance. Two lactose carrier systems comprising either spray dried or milled particles were developed such that they had identical physical characteristics except for surface morphology and surface energies avoiding confounding variables common in other studies. Surface energy measurements confirmed significant differences between the powder systems. Spray dried lactose had a higher surface entropy (0.20 vs. 0.13 mJ/m2K) and surface enthalpy (103.2 vs. 79.2 mJ/m2) compared to milled lactose.Mixing rates of budesonide or fluorescein were assessed dynamically and significant differences in blending were observed between lactose systems for both drugs. Surface energies of the lactose carriers were inversely proportional to dispersion performance. In addition, the root mean square of blending rates correlated positively with aerosol dispersion performance. Both techniques have potential utility in routine screening dry powder inhaler formulations.3

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Section: Surface Energy Analysis Of Lactosementioning

confidence: 99%

Prediction of Dry Powder Inhaler Formulation Performance From Surface Energetics and Blending Dynamics

Saleem

Smyth

Telko

2008

Drug Development and Industrial Pharmacy

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“…10,17 Penetration into capillaries is governed by immersional wetting where solid-vapor interface is replaced by solid-liquid interface. 18,20 The surface free energy change per unit area, a, for this process is:…”

Section: Introductionmentioning

confidence: 99%