The wetting of powders by bile salt solutions and gastric juice

The role of bile salts in digestion

“…Yet, the importance of the surface activity of BS in their biological role was already recognized by Hofmann in the seventies [4,10]. Also, there appeared works identifying the implications of wetting characteristics of BS in the design of physiologically based dissolution media [11,12]. Although investigation of the adsorption behaviour of classical surfactants onto air-water and oil-water interfaces has proven to be extremely useful in furthering understanding of their diffusion and aggregation behaviour, the interfacial tension profiles are often not reported in the literature.…”

Wetting Properties of Bile Salt Solutions and Dissolution Media

“…Fell et al 26 found that a mixture of CH and DCH had an adhesion tension profile with a negative slope for paraffin whereas on phenobarbitone the slope was initially negative and then approached zero at lower surface tensions. Since to a large extent the wetting behavior of the solid will be determined by the ratio of surface excesses, 56,61 the properties of the substrate that contribute to adsorption will be influential in determining the wetting.…”

“…9 However, there has been much less research devoted to the wetting properties of these solutions. 25,26 Wetting of drugs by bile salts or other surfactants can have a major impact on dissolution independent of solubility. 25,27,28 Wetting can also be an influential factor in the release of drugs from inert matrices.…”

Impact of Surface Tension in Pharmaceutical Sciences

“…These factors should be considered because they have a significant impact on properties of drugs, such as uptake, distribution, transport, and eventually bioavailability (7,8). By applying special surface treatments such as contact angle and surface tension measurements to pharmaceutical compounds, drug distribution, dissolution behavior and release pattern in various body fluids can be improved.…”