The what-decision in manual action: ERPs for free choice versus specified overt goal-related grasping

Westerholz, Jan; Schack, Thomas; Koester, Dirk

doi:10.1016/j.neulet.2014.05.022

Cited by 5 publications

(6 citation statements)

References 19 publications

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“…The inferior parietal cortex, described primarily by Litvan (Aarsland et al, 1999), in cortico-basal degeneration patients, where apathy is much more common than in PSP or PD [data confirmed in Moretti et al (2005) (Hoffstaedter et al, 2013; Westerholz et al, 2014)], is involved too. By means of fMRI, the inferior parietal cortex (Westerholz et al, 2014) increased activation (among other regions in the fronto-subcortical network) during self-initiated movements and goal-directed behavior in a healthy sample (Jenkins et al, 2000; Desmurget and Sirigu, 2009; Westerholz et al, 2014; Kos et al, 2016). …”

Section: Conclusive Statementmentioning

confidence: 94%

Neural Correlates for Apathy: Frontal-Prefrontal and Parietal Cortical- Subcortical Circuits

Moretti

Signori

2016

Front. Aging Neurosci.

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Apathy is an uncertain nosographical entity, which includes reduced motivation, abulia, decreased empathy, and lack of emotional involvement; it is an important and heavy-burden clinical condition which strongly impacts in everyday life events, affects the common daily living abilities, reduced the inner goal directed behavior, and gives the heaviest burden on caregivers. Is a quite common comorbidity of many neurological disease, However, there is no definite consensus on the role of apathy in clinical practice, no definite data on anatomical circuits involved in its development, and no definite instrument to detect it at bedside. As a general observation, the occurrence of apathy is connected to damage of prefrontal cortex (PFC) and basal ganglia; “emotional affective” apathy may be related to the orbitomedial PFC and ventral striatum; “cognitive apathy” may be associated with dysfunction of lateral PFC and dorsal caudate nuclei; deficit of “autoactivation” may be due to bilateral lesions of the internal portion of globus pallidus, bilateral paramedian thalamic lesions, or the dorsomedial portion of PFC. On the other hand, apathy severity has been connected to neurofibrillary tangles density in the anterior cingulate gyrus and to gray matter atrophy in the anterior cingulate (ACC) and in the left medial frontal cortex, confirmed by functional imaging studies. These neural networks are linked to projects, judjing and planning, execution and selection common actions, and through the basolateral amygdala and nucleus accumbens projects to the frontostriatal and to the dorsolateral prefrontal cortex. Therefore, an alteration of these circuitry caused a lack of insight, a reduction of decision-making strategies, and a reduced speedness in action decision, major responsible for apathy. Emergent role concerns also the parietal cortex, with its direct action motivation control. We will discuss the importance of these circuits in different pathologies, degenerative or vascular, acute or chronic.

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Section: Conclusive Statementmentioning

confidence: 94%

Neural Correlates for Apathy: Frontal-Prefrontal and Parietal Cortical- Subcortical Circuits

Moretti

Signori

2016

Front. Aging Neurosci.

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“…The ROIs were arranged in relation to the frontal and posterior ERP effects in previous work [33,36,41,42,37]. Average ERP amplitudes were calculated separately for each ROI and for each experimental condition.…”

Section: Methodsmentioning

confidence: 99%

“…Hence, it remains still difficult to distinguish between action planning and execution with regard to those ERP measures. In contrast, response-locked ERP analyses of grasping movements have yielded slow waves at frontal and posterior electrodes, e.g., [33,41,42] or modulations of the Bereitschaftspotential (BP [35,43]) which also varied between frontal and posterior electrodes but these grasping studies did not consider additionally language processes. After all, the time window of the reported N400-like effect indicating grasp-related information processing is, generally, in line with the extended durations of slow waves in other ERP studies on grasping [33,35,41,42].…”

Section: Introductionmentioning

confidence: 99%

Action Priority: Early Neurophysiological Interaction of Conceptual and Motor Representations

Koester

Schack

2016

PLoS ONE

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Handling our everyday life, we often react manually to verbal requests or instruction, but the functional interrelations of motor control and language are not fully understood yet, especially their neurophysiological basis. Here, we investigated whether specific motor representations for grip types interact neurophysiologically with conceptual information, that is, when reading nouns. Participants performed lexical decisions and, for words, executed a grasp-and-lift task on objects of different sizes involving precision or power grips while the electroencephalogram was recorded. Nouns could denote objects that require either a precision or a power grip and could, thus, be (in)congruent with the performed grasp. In a control block, participants pointed at the objects instead of grasping them. The main result revealed an event-related potential (ERP) interaction of grip type and conceptual information which was not present for pointing. Incongruent compared to congruent conditions elicited an increased positivity (100–200 ms after noun onset). Grip type effects were obtained in response-locked analyses of the grasping ERPs (100–300 ms at left anterior electrodes). These findings attest that grip type and conceptual information are functionally related when planning a grasping action but such an interaction could not be detected for pointing. Generally, the results suggest that control of behaviour can be modulated by task demands; conceptual noun information (i.e., associated action knowledge) may gain processing priority if the task requires a complex motor response.

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“…Interestingly, a bilateral frontal slow wave time-locked to movement end was more negative for non-habitual grasping but there were no posterior ERP effects. Similar to Westerholz et al (2014a), grip specification yielded also no ERP effects. Whether the absence of posterior effects is related to a “missing” transport phase, to the nature of the task (rotation vs. transport) or the functionality of the rotation (Tucker and Ellis, 1998) remains to be shown.…”

Section: Introductionmentioning

confidence: 81%

“…Similar to anticipations, Westerholz et al (2014a) investigated the role of intentional processes in grasping, that is, the decision what action to perform. These authors investigated the neurophysiological correlates of planning and execution of goal-related grasping and the dominance of an immediate “goal” (grip configuration) and a final goal (goal state).…”

Section: Introductionmentioning

confidence: 99%

Neurophysiology of Grasping Actions: Evidence from ERPs

2016

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We use our hands very frequently to interact with our environment. Neuropsychology together with lesion models and intracranial recordings and imaging work yielded important insights into the functional neuroanatomical correlates of grasping, one important function of our hands, pointing toward a functional parietofrontal brain network. Event-related potentials (ERPs) register directly electrical brain activity and are endowed with high temporal resolution but have long been assumed to be susceptible to movement artifacts. Recent work has shown that reliable ERPs can be obtained during movement execution. Here, we review the available ERP work on (uni) manual grasping actions. We discuss various ERP components and how they may be related to functional components of grasping according to traditional distinctions of manual actions such as planning and control phases. The ERP results are largely in line with the assumption of a parietofrontal network. But other questions remain, in particular regarding the temporal succession of frontal and parietal ERP effects. With the low number of ERP studies on grasping, not all ERP effects appear to be coherent with one another. Understanding the control of our hands may help to develop further neurocognitive theories of grasping and to make progress in prosthetics, rehabilitation or development of technical systems for support of human actions.

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The what-decision in manual action: ERPs for free choice versus specified overt goal-related grasping

Cited by 5 publications

References 19 publications

Neural Correlates for Apathy: Frontal-Prefrontal and Parietal Cortical- Subcortical Circuits

Neural Correlates for Apathy: Frontal-Prefrontal and Parietal Cortical- Subcortical Circuits

Action Priority: Early Neurophysiological Interaction of Conceptual and Motor Representations

Neurophysiology of Grasping Actions: Evidence from ERPs

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