The Wiley / NBS Registry of Mass Spectral Data, Volumes 1-7 (McLafferty, Fred W.; Stauffer, Douglas B.)

Johnston, Christine

doi:10.1021/ed066pa256.3

Cited by 6 publications

(3 citation statements)

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“…The mass spectra of SV.CR compounds were also screened with the spectra similar compounds in the Adams Library (Adams, 2007) and the Wiley GC/MS Library. 38 …”

Section: Methodsmentioning

confidence: 99%

Chemical Profiling and Dose-Dependent Assessment of Fear Reducing and Memory-Enhancing Effects of Solanum virginianum in Rats

et al. 2021

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The current study was planned to investigate the pharmacological basis of Solanum virginianum extract (SV.CR) pertaining to anxiolytic, antidepressant and memory-enhancing effects in rats. The SV.CR was analyzed in-vitro for phytoconstituents, antioxidant potential and anticholinesterase activity. The rats treated in a dose-dependent manner (25, 50 and 100 mg/kg of SV.CR) were subjected to behavioral tests for anxiety, depression and memory judgment followed by biochemical studies. A notable dose-dependent anxiolytic potential of SV.CR was observed in elevated plus maze and open field tests (P < 0.05). The decreased immobility time of the treated rats in the forced swim test (P < 0.01) unveiled the plant’s potential to reduce depression. Moreover, SV.CR treatment also reversed scopolamine-impaired cognition (P < 0.05) in various deployed memory and learning tasks. Biochemical studies of brain homogenates of SV.CR treated animals demonstrated decreased anticholinesterase activity and lipid peroxidation levels whereas increased levels of superoxide dismutase and glutathione peroxidase (P < 0.05 vs scopolamine group) were noted. The scientific validation of the study supported the use of Solanum virginianum in reducing anxiety, depression and amnesia in experimental models. Phytoconstituents in SV.CR such as oleanolic acid and caffeic acid might have played a significant neuroprotective role via modulation of oxidative stress and neurochemical aspects.

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“…The mass spectra of SV.CR compounds were also screened with the spectra similar compounds in the Adams Library (Adams, 2007) and the Wiley GC/MS Library. 38 …”

Section: Methodsmentioning

confidence: 99%

Chemical Profiling and Dose-Dependent Assessment of Fear Reducing and Memory-Enhancing Effects of Solanum virginianum in Rats

et al. 2021

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“…The mass spectra were obtained in EI‐scan mode at 70 eV electron energy, an ion source temperature of 250°C, and the scan range for the sector mass analyzer was 35 to 500 amu. The essential oil components were identified by comparing their retention indexes (relative to n‐alkanes) and mass spectra of each peak with those found in mass spectrum library (NIST11) and literature [42, 43]. The area normalization method was used to determine the percentage of compounds as described in our previous investigation [44].…”

Section: Methodsmentioning

confidence: 99%

Proteomic analysis suggests that monoterpenes in lemongrass disrupt Ca²⁺ homeostasis in Haemaphysalis longicornis leading to mitochondrial depolarization and cytotoxicity

Agwunobi

Wang

et al. 2022

Proteomics

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Complex mixtures of bioactive ingredients in plant essential oils present complex chemistries which involve different modes of action. An increasing body of scientific reports has recently focused on the acaricidal activities of plant essential oils attributed to their monoterpene components, but information about their underlying molecular mechanism of action is scarce. Here, after the chemical analysis of lemongrass oil, a proteomic analysis of the ovary, salivary gland, and midgut of Haemaphysalis longicornis exposed to Cymbopogon citratus (lemongrass) essential oil was performed via data‐independent acquisition mass spectrometry (DIA‐MS) technology to further elucidate the molecular mechanisms involved. Pathway analysis reveals the activation of metabolic pathways mediated by oxidoreductases and transferases. Furthermore, the upregulation of various calcium‐associated proteins and the upregulation of cytochrome c1, cytochrome c oxidase polypeptide IV, and programmed cell death protein 6‐like isoform X1 suggest a cytotoxic mode of action via the formation of reactive oxygen species (ROS), mitochondrial Ca2+ overload, mitochondrial uncoupling, and depolarization, and ATP depletion leading to either apoptotic or necrotic death. Morphological alterations observed after the RNAi of a major detoxification enzyme (glutathione S‐transferase) merit further investigation. Hence, the cytotoxic mode of action exhibited by C. citratus oil could be vital for the development of eco‐friendly acaricide.

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“…GC-MS analyses were carried out on a 7890A gas chromatograph coupled to a 5975C quadrupole mass detector (both from Agilent Technologies, Palo Alto, CA, USA), using He at~1 mL min −1 as carrier gas. Injections were carried out in split mode (1 Qualitative analysis was based on the comparison of experimental mass spectra with data from the Wiley mass spectral library [13] and was confirmed, when possible, by using linear retention indices (I T ) [14,15]. Semiquantitative data (percentage of total volatiles) were directly calculated from peak areas of total ion current (TIC) profiles.…”

Section: Gas Chromatography-mass Spectrometry (Gc-ms) Analysismentioning

confidence: 99%

Analysis of the Essential Oils of Chamaemelum fuscatum (Brot.) Vasc. from Spain as a Contribution to Reinforce Its Ethnobotanical Use

Fernández-Cervantes

Pérez‐Alonso

Salas

et al. 2019

Forests

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Chamaemelum fuscatum (Brot.) Vasc. is a south west Iberian chamomile that has been traditionally used as folk medicine in its natural distribution area but currently it is underestimated regarding its biological activities. For this reason, it is proposed in this paper to get insight into the scientific validation of the traditional knowledge of this plant with the aim of taking advantage of its anti-inflammatory, gastroprotective and antinociceptive activities, among others. To this aim, the chemical composition of the essential oil from the whole plant, the flowers and the green parts of this plant has been evaluated by gas chromatography–mass spectrometry (GC–MS). Plant materials were collected in Badajoz (Spain). A total of 61 components including monoterpenoids, sesquiterpenoids and aliphatic esters were identified. (E)-2-Methyl-2-butenyl methacrylate (27.57%–18.53%) and 2-methylallyl isobutyrate (9.79%–7.51%) were the most abundant compounds in the essential oils of flowers and of the whole plant, whereas α-curcumene, trans-pinocarveol, α-bergamotene and pinocarvone were the major terpenoids irrespective of the plant part considered. Certain compounds showing a relative high abundance as isobutyl methacrylate, isoamyl butyrate, α-bergamotene and pinocarvone were identified for the first time in this species. Finally, we have reviewed the bioactivity of several compounds to relate the ethnobotanical use of this plant in Spain with its volatile profile. This work is a preliminary contribution to reinforce the use to this Mediterranean endemic plant as a natural source of bioactives.

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The Wiley / NBS Registry of Mass Spectral Data, Volumes 1-7 (McLafferty, Fred W.; Stauffer, Douglas B.)

Cited by 6 publications

References 0 publications

Chemical Profiling and Dose-Dependent Assessment of Fear Reducing and Memory-Enhancing Effects of Solanum virginianum in Rats

Chemical Profiling and Dose-Dependent Assessment of Fear Reducing and Memory-Enhancing Effects of Solanum virginianum in Rats

Proteomic analysis suggests that monoterpenes in lemongrass disrupt Ca²⁺ homeostasis in Haemaphysalis longicornis leading to mitochondrial depolarization and cytotoxicity

Analysis of the Essential Oils of Chamaemelum fuscatum (Brot.) Vasc. from Spain as a Contribution to Reinforce Its Ethnobotanical Use

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The Wiley / NBS Registry of Mass Spectral Data, Volumes 1-7 (McLafferty, Fred W.; Stauffer, Douglas B.)

Cited by 6 publications

References 0 publications

Chemical Profiling and Dose-Dependent Assessment of Fear Reducing and Memory-Enhancing Effects of Solanum virginianum in Rats

Chemical Profiling and Dose-Dependent Assessment of Fear Reducing and Memory-Enhancing Effects of Solanum virginianum in Rats

Proteomic analysis suggests that monoterpenes in lemongrass disrupt Ca2+ homeostasis in Haemaphysalis longicornis leading to mitochondrial depolarization and cytotoxicity

Analysis of the Essential Oils of Chamaemelum fuscatum (Brot.) Vasc. from Spain as a Contribution to Reinforce Its Ethnobotanical Use

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Proteomic analysis suggests that monoterpenes in lemongrass disrupt Ca²⁺ homeostasis in Haemaphysalis longicornis leading to mitochondrial depolarization and cytotoxicity