The Wnt/β-catenin signalling pathway in Haematological Neoplasms

Yu, Shi; Han, Ruyue; Gan, Runliang

doi:10.1186/s40364-022-00418-9

Cited by 13 publications

(7 citation statements)

References 122 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wnt/ β-catenin signaling pathway dysregulation is the tipping point in tumor progression, invasion, and metastasis via its effect on β-catenin and Cyclin D1. (21) Concerning β-catenin results in the present study, immunopositivity was found in normal oral epithelium with membranous expression in all epithelial cell layers. These findings were consistent with previous study that found β-catenin expression was detected only in the cytoplasmic membrane of the normal oral mucosa.…”

Section: Discussionsupporting

confidence: 41%

Role of the Wnt signalling pathway in oral cancer

abdelsamia

2023

Egyptian Dental Journal

View full text Add to dashboard Cite

The sixth most dangerous cancer worldwide is oral cancer. Pre-cancer disorders are often present in many patients before oral cancer develops. Several types of human cancer have been linked to abnormal activation of Wnt/β-catenin signaling, which is characterized by β-catenin translocation and overexpression of Wnt ligands. β-catenin interacts with the transcription factor during canonical Wnt/β-catenin signaling to activate downstream target genes such as Cyclin D1, which is primarily associated with cellular proliferation. This study aims to evaluate the role of β-catenin and Cyclin D1 in epithelial dysplasia and various stages of oral squamous cell carcinoma (OSCC) via the Wnt signaling pathway. For the present study, 5 cases of normal oral epithelial tissues, 10 cases of severe epithelial dysplasia, and 30 cases of various grades of OSCC (10 cases for each grade) were collected as paraffin-embedded blocks. All specimens were immunohistochemically stained for β-catenin and Cyclin D1 antibodies. β-catenin immunostaining showed the highest mean area percentage found in normal epithelial tissue, whereas the lowest values were recorded in poorly-differentiated OSCC, while Cyclin D1 immunostaining showed the lowest mean area percent was recorded in normal epithelial tissue, whereas the highest values were noted in poorlydifferentiated OSCC. Conclusion: Aberrant cytoplasmic expression of β-catenin act as a co-factor, activating Cyclin D1 lead to high proliferative activity and invasion potential. Thus associations of both molecules has greater role in transformation from normal to dysplastic cells and increase their invasiveness to OSCC.

show abstract

Section: Discussionsupporting

confidence: 41%

Role of the Wnt signalling pathway in oral cancer

abdelsamia

2023

Egyptian Dental Journal

View full text Add to dashboard Cite

show abstract

“…On the other hand, the dysregulation of the Wnt/β-catenin pathway is often associated with a variety of diseases, including cancer [ 62 , 63 ]. In colorectal cancers, the Wnt/β-catenin pathway is one of the most important signaling pathways [ 64 ]; therefore, the Wnt/β-catenin signaling pathway is an attractive target for cancer treatment and several small inhibitors targeting the Wnt/β-catenin pathway have been examined in preclinical and clinical studies [ 65 , 66 , 67 ]. In addition, some studies have indicated that chalcones are also capable of acting on this signaling pathway.…”

Section: Molecular and Cellular Mechanisms Of Actionmentioning

confidence: 99%

Chalcones and Gastrointestinal Cancers: Experimental Evidence

Michalková

Kello

Čižmáriková

et al. 2023

IJMS

View full text Add to dashboard Cite

Colorectal (CRC) and gastric cancers (GC) are the most common digestive tract cancers with a high incidence rate worldwide. The current treatment including surgery, chemotherapy or radiotherapy has several limitations such as drug toxicity, cancer recurrence or drug resistance and thus it is a great challenge to discover an effective and safe therapy for CRC and GC. In the last decade, numerous phytochemicals and their synthetic analogs have attracted attention due to their anticancer effect and low organ toxicity. Chalcones, plant-derived polyphenols, received marked attention due to their biological activities as well as for relatively easy structural manipulation and synthesis of new chalcone derivatives. In this study, we discuss the mechanisms by which chalcones in both in vitro and in vivo conditions suppress cancer cell proliferation or cancer formation.

show abstract

“…The increase in BALP and PINP indirectly reflects the increase in bone loss, and the change in clinical bone metabolic index occurs half a year earlier than bone density, so it is suitable for short-term observation indexes. Therefore, these two indexes can be used as reference indexes for the diagnosis and evaluation of curative effects after treatment [32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Bone protection mechanism of Zuogui Pill in an osteoporosis model of breast cancer rats after endocrine therapy

ao,

Chunhui,

Lei

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Postmenopausal breast cancer patients treated with aromatase inhibitors (AIs) have an increased risk of developing secondary osteoporosis. Zuogui Pill has been proven to have obvious preventative and therapeutic effects against osteoporosis in the clinic. However, the possible mechanism of this bone-protective mechanism of Zuogui Pill is still largely unknown.Methods An osteoporosis model of postmenopausal breast cancer was generated by gavage of letrozole in ovariectomized mice with breast cancer. Serum oestradiol (E2), bone alkaline phosphatase (BALP), and amino terminal propeptide of type Ⅰ collagen (PINP) were detected by enzyme-related immunosorbent assays (ELISAs). After death, the right femur and tibia were taken and stained with HE to observe the bone histopathology. Microcomputed tomography (µCT) was used to detect bone density and trabecular microstructure in vitro. The protein expression levels of Wnt3a, β-catenin and Runx2 in bone tissue were detected by Western blots.Results Zuogui Pill significantly decreased the serum level of bone alkaline phosphatase (BALP) and the level of amino terminal procollagen Ⅰ propeptide (PINP) but had no significant effect on oestradiol (E2). Zuogui Pill improved bone tissue morphology, bone microstructure and bone mineral density. The protein expression levels of Wnt3a, β-catenin and Runx2 in the Zuogui Pill groups were significantly increased.Conclusion Zuogui Pill exerts a bone-protective effect through the Wnt/β-catenin and Wnt/Runx2 pathways and has good application value for the treatment of osteoporosis.

show abstract

The Wnt/β-catenin signalling pathway in Haematological Neoplasms

Cited by 13 publications

References 122 publications

Role of the Wnt signalling pathway in oral cancer

Role of the Wnt signalling pathway in oral cancer

Chalcones and Gastrointestinal Cancers: Experimental Evidence

Bone protection mechanism of Zuogui Pill in an osteoporosis model of breast cancer rats after endocrine therapy

Contact Info

Product

Resources

About